Areas of Focus
- 人工智能与生命科学交叉
- 结构生物学
- 基因组学
- RNA生物学
- 单细胞基因组学
- 基于冷冻电镜的蛋白质结构建模
- 生物医学数据的人工智能算法开发
Work Experience
- 2011-2012 哥伦比亚大学计算生物学和生物信息学中心 博士后
- 2012-2015 斯坦福大学医学院 博士后
- 2015-2018 清华大学生命科学学院 助理教授
- 2018-至今 清华大学生命科学学院副教授
Academic Background & Achievements
- 1996-2000 学士:中国科学技术大学
- 2000-2006 计算机科学博士:中国科学技术大学
- 2006-2011 生物化学和分子生物物理博士:哥伦比亚大学
Publications
- Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human, 张强锋 等.
- Online single-cell data integration through projecting heterogeneous datasets into a common cell-embedding space, 张强锋 等.
- Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2, 张强锋 等.
- A deep learning method for recovering missing signals in transcriptome-wide RNA structure profiles from probing experiments, 张强锋 等.
- RNA structure probing reveals the structural basis of Dicer binding and cleavage, 张强锋 等.
- In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs, 张强锋 等.
- Predicting dynamic cellular protein-RNA interactions by deep learning using in vivo RNA structures, 张强锋 等.
- Keth-seq for transcriptome-wide RNA structure mapping, 张强锋 等.
- SCALE method for single-cell ATAC-seq analysis via latent feature extraction, 张强锋 等.
- RNA structure maps across mammalian cellular compartments, 张强锋 等.
- A2-Net: Molecular Structure Estimation from Cryo-EM Density Volumes, 张强锋 等.
- Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity, 张强锋 等.