Professor | 许杰 | 数字化转型顾问

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Name	许杰
Contact Information	xj_nju@126.com
Language ability	中文, 英语
Province	湖北

Upload Avatar (500 x 500)

Name

许杰

Contact Information

xj_nju@126.com

Language ability

中文, 英语

Province

湖北

University/Lab Affiliation and Title	武汉大学
Faculty	Medical School
Academic Background & Achievements	2006-09至2010-06，南京大学，生命科学院，生物，学士 2010-09至2015-06，南京大学，生命科学院，生物化学，博士 2013-07至2015-06，哈佛医学院，BIDMC，内分泌系，神经和代谢，博士（联合培养）
Work Experience	2015-08至2021-02，塔夫茨大学，神经生物学系，博士后 2021-03至2023-09，哈佛医学院，波士顿儿童医院，内分泌系，讲师 2023-10至今，武汉大学，泰康医学院（基础医学院），教授

University/Lab Affiliation and Title

武汉大学

Faculty

Medical School

Academic Background & Achievements

2006-09至2010-06，南京大学，生命科学院，生物，学士
2010-09至2015-06，南京大学，生命科学院，生物化学，博士
2013-07至2015-06，哈佛医学院，BIDMC，内分泌系，神经和代谢，博士（联合培养）

Work Experience

2015-08至2021-02，塔夫茨大学，神经生物学系，博士后
2021-03至2023-09，哈佛医学院，波士顿儿童医院，内分泌系，讲师
2023-10至今，武汉大学，泰康医学院（基础医学院），教授

Areas of Focus	代谢的神经调控瘦素抵抗的分子机制研究肥胖、厌食症中摄食信号的功能研究恶病质的中枢调节机制研究血糖的中枢调节研究
Publications	Genetic identification of leptin neural circuits in energy and glucose homeostasis, Jie Xu, Bartolome CL, Low CS, Yi X, Chien CH, Wang P, Kong D, 2018 Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways, Jie Xu, Chen Q, Zen K, Zhang C, Zhang Q, 2013 Small RNA existed in commercial reverse transcriptase: primary evidence of functional small RNAs, Jie Xu, Xi Chen, Donghai Li, Qun Chen, Zhen Zhou, Dongxia Hou, Jin Wang, Qipeng Zhang, Ke Zen, Chen-Yu Zhang, 2014 MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis, Q Chen, Jie Xu, L Li, H Li, S Mao, F Zhang, K Zen, CY Zhang, Q Zhang, 2014 Selective secretion of microRNA in CNS system, Zhang Q, Jie Xu, Chen Q, Chen X, Zen K, Zhang CY, 2014 Identification and characterization of the MicroRNA profile in aging rats with erectile dysfunction, Pan F, Jie Xu, Zhang Q, Qiu X, Yu W, Jiadong Xia, Taowei Chen, Lianjun Pan, Yun Chen, Yutian Dai, 2014 SIDT1dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs, Chen Q, Zhang F, Dong L, Wu H, Jie Xu, Li H, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F, Zhang Q, Zhang CY, 2020 A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by αMSH, Henning Fenselau, John N Campbell, Anne MJ Verstegen, Joseph C Madara, Jie Xu, Bhavik P Shah, Jon M Resch, Zongfang Yang, Yael Mandelblat-Cerf, Yoav Livneh, Bradford B Lowell, 2017 PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Jie Xu, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC, 2020 Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, Dheeraj S Roy, Ying Zhang, Tomomi Aida, Soonwook Choi, Qian Chen, Yuanyuan Hou, Nicholas E Lea, Keith M Skaggs, Juliana C Quay, Min Liew, Vinh Le, Carter Jones, Jie Xu, Dong Kong, Heather A Sullivan, Arpiar Saunders, Steven A McCarroll, Ian R Wickersham, Guoping Feng, 2021

Areas of Focus

代谢的神经调控
瘦素抵抗的分子机制研究
肥胖、厌食症中摄食信号的功能研究
恶病质的中枢调节机制研究
血糖的中枢调节研究

Publications

Genetic identification of leptin neural circuits in energy and glucose homeostasis, Jie Xu, Bartolome CL, Low CS, Yi X, Chien CH, Wang P, Kong D, 2018
Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways, Jie Xu, Chen Q, Zen K, Zhang C, Zhang Q, 2013
Small RNA existed in commercial reverse transcriptase: primary evidence of functional small RNAs, Jie Xu, Xi Chen, Donghai Li, Qun Chen, Zhen Zhou, Dongxia Hou, Jin Wang, Qipeng Zhang, Ke Zen, Chen-Yu Zhang, 2014
MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis, Q Chen, Jie Xu, L Li, H Li, S Mao, F Zhang, K Zen, CY Zhang, Q Zhang, 2014
Selective secretion of microRNA in CNS system, Zhang Q, Jie Xu, Chen Q, Chen X, Zen K, Zhang CY, 2014
Identification and characterization of the MicroRNA profile in aging rats with erectile dysfunction, Pan F, Jie Xu, Zhang Q, Qiu X, Yu W, Jiadong Xia, Taowei Chen, Lianjun Pan, Yun Chen, Yutian Dai, 2014
SIDT1dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs, Chen Q, Zhang F, Dong L, Wu H, Jie Xu, Li H, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F, Zhang Q, Zhang CY, 2020
A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by αMSH, Henning Fenselau, John N Campbell, Anne MJ Verstegen, Joseph C Madara, Jie Xu, Bhavik P Shah, Jon M Resch, Zongfang Yang, Yael Mandelblat-Cerf, Yoav Livneh, Bradford B Lowell, 2017
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Jie Xu, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC, 2020
Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, Dheeraj S Roy, Ying Zhang, Tomomi Aida, Soonwook Choi, Qian Chen, Yuanyuan Hou, Nicholas E Lea, Keith M Skaggs, Juliana C Quay, Min Liew, Vinh Le, Carter Jones, Jie Xu, Dong Kong, Heather A Sullivan, Arpiar Saunders, Steven A McCarroll, Ian R Wickersham, Guoping Feng, 2021

代谢神经调控瘦素抵抗肥胖厌食症摄食信号恶病质中枢调节血糖神经生物学

代喆 - 武汉大学

穆杨 - 武汉大学

李婕 - 南京大学

Area of Focus
脂肪性肝病: 肝脏 | 脂肪变性 | Nafld | Nash | 代谢 | 炎症 | 纤维化 | 肝病学 | 脂质 | 肥胖 | 病毒性肝炎: Hbv | Hcv | 肝脏 | 感染 | 肝硬化 | 抗病毒 | 免疫反应 | 慢性

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