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张秀琴
Life Sciences / Medical / Biology
北京大学
北京
Language: 中文, 日语, 英语
代谢疾病
心血管疾病
动物模型
灵长类
肥胖
脂肪肝
2型糖尿病
发病机理
药效学
临床前研究
Areas of Focus
- 灵长类动物代谢及心血管疾病动物模型的建立及研究
- 利用灵长类及啮齿类动物模型进行肥胖、脂肪肝及2型糖尿病的发病机理研究
- 利用灵长类动物模型进行临床前药效学研究
Work Experience
- 1995.7-1996.6 - 中国医学科学院阜外医院 - 住院医师
- 1996.7-1997.3 - 日本熊本大学医学部 - 客座研究员
- 1997.4-1998.3 - 日本熊本大学医学部 - 日本文部省特别研究员（非常勤讲师）
- 2002.4-2006.3 - 美国华盛顿大学医学院 - 博士后
- 2006.4-2013.8 - 北京大学分子医学研究所 - 副研究员
- 2013.9 - 现在 - 北京大学未来技术学院 - 研究员
Academic Background & Achievements
- 1992-1995 硕士学位: 中国医科大学, 导师: 李宗铉
- 1998-2002 博士学位: 日本熊本大学医学部, 导师: Toshio Suda
Publications
- A chemical approach for global protein knockdown from mice to non-human primates, Sun X, Wang J, Yao X, Zheng W, Mao Y, Lan T, Wang L, Sun Y, Zhang X, Zhao Q, Zhao J, Xiao RP, Zhang X*, Ji G*, Rao Y*, 2019
- Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus, Wang C, Xiao Y, Wang J, Hou N, Cui W, Hu X, Zeng F, Yuan Y, Ma D, Sun X, Zhang Y, Zheng W, Liu Y, Shang H, Chen L, Xiao RP, Zhang X*, 2019
- Central role of RIPK1-VDAC1 pathway on cardiac impairment in a non-human primate model of rheumatoid arthritis, Zeng F, Wen W, Cui W, Zheng W, Liu Y, Sun X, Hou N, Ma D, Yuan Y, Shi H, Wang Z, Li Z, Xiao Y, Wang C, Li Y, Shang H, Li C, Wang J, Zhang Y, Xiao RP, Zhang X*, 2018
- Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys, Zheng W, Liu Y, Shang H, Zhang Y, Ma D, Hou N, Wang J, Sun X, Peng Y, Pan L, Wang Z, Tang X, Xiao RP, Zhang X*, 2018
- Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders, Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, Zhu W, Han C, Zhang Y, Ouyang K, Chen L, Chen J, Xiao RP, Li CY, Zhang X*, 2018
- RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis, Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, Ma D, Yuan Y, Li Z, Hou N, Zhao H, Bi X, Zhao J, Zhou J, Zhang Y, Xiao RP, Cai J, Zhang X*, 2018
- Eplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome, Zhang Y, Zheng W, Liu Y, Wang J, Peng Y, Shang H, Hou N, Hu X, Ding Y, Xiao Y, Wang C, Zeng F, Mao J, Zhang J, Ma D, Sun X, Li C, Xiao RP, Zhang X*, 2016
