Professor | 陈昌斌 | 数字化转型顾问

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Name	陈昌斌
Contact Information	cbchen@ips.ac.cn
Language ability	英语, 中文
Province	上海

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Name

陈昌斌

Contact Information

cbchen@ips.ac.cn

Language ability

英语, 中文

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1998-08--2004-08 博士: 美国内布拉斯加州立大学林肯分校 1995-08--1998-08 硕士: 中国科学院上海植物生理生态研究所 1990-08--1994-06 学士: 复旦大学
Work Experience	2013-07 至今 - 中国科学院上海巴斯德研究所 - 研究员，博士生导师 2011-07 至 2013-06 - 美国加州大学旧金山分校 - 助理研究员 2005-07 至 2011-06 - 美国加州大学旧金山分校 - 博士后 2004-09 至 2005-06 - 美国内布拉斯加州立大学林肯分校 - 研究助理

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1998-08--2004-08 博士: 美国内布拉斯加州立大学林肯分校
1995-08--1998-08 硕士: 中国科学院上海植物生理生态研究所
1990-08--1994-06 学士: 复旦大学

Work Experience

2013-07 至今 - 中国科学院上海巴斯德研究所 - 研究员，博士生导师
2011-07 至 2013-06 - 美国加州大学旧金山分校 - 助理研究员
2005-07 至 2011-06 - 美国加州大学旧金山分校 - 博士后
2004-09 至 2005-06 - 美国内布拉斯加州立大学林肯分校 - 研究助理

Areas of Focus	人类病原真菌与宿主互作的分子机制白色念珠菌共生-致病转换的重要信号通路真菌效应因子与宿主抗真菌免疫真菌突破宿主血脑屏障的分子机制肠道与生殖道菌群如何影响真菌感染及宿主免疫新型抗真菌药物筛选及相关作用机制真菌耐药的表观遗传调控机制
Publications	Candida Infections: an update on host immune defenses and anti-fungal drugs, Gao, N., and Chen, C., 2016 Passage through the mammalian gut triggers a phenotypic switch required for Candida albicans commensalism, Pande, K., Chen, C. and Noble, S. M., 2013 Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host, Chen, C. and Noble, S. M., 2012 A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis, Chen, C., Pande, K., French, S. D., Tuch, B. B. and Noble, S. M., 2011 Stalled spliceosomes are a signal for RNA-mediated genome defense, Dumesic, P., Natarajan, P., Chen, C., Drinnenberg, A., Schiller, B., Moresco, J., Thompson, J., Yates, J., Bartel, D., and Madhani H., 2013 Systematic gene deletion and analysis of virulence in the human fungal pathogen Cryptococcus neoformans, Liu, O. W., Chun, C. D., Chow, E. D., Chen, C., Madhani, H. D. and Noble, S. M., 2008 Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii, Chen, C. and Dickman, M. B., 2005 Shp2 mediates C-type lectin receptor-induced Syk activation and anti-fungal Th17 responses, Deng Z., Ma S., Zhou H., Zang A., Fang Y., Li T., Shi H., Liu M., Du M., Taylor P., Zhu H., Chen J., Meng G., Li F., Chen C., Zhang Y., Jia X., Lin X., Zhang X., Pearlman E., Li X., Feng G., and Xiao H., 2015 Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2, Xie X., Li F., Wang Y., Lin Z., Cheng X., Liu J., Chen C., and Pan L., 2015 Internalized Cryptococcus neoformans activates the canonical Caspase-1 and the noncanonical Caspase-8 inflammasomes, Chen M., Xing Y., Lu A., Fang W., Sun B., Chen C., Liao W., and Meng G., 2015 Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome, Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G., 2014 A site specific acetylation mark on the essential RSC chromatin remodeling complex promotes resistance to replication stress, Georgette, C., Chen, C., Shih, S., et al., 2011 cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum, Chen, C., and Dickman, M. B., 2005 Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signaling pathways, Chen, C., and Dickman, M. B., 2004 Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichum trifolii, Chen

Areas of Focus

人类病原真菌与宿主互作的分子机制
白色念珠菌共生-致病转换的重要信号通路
真菌效应因子与宿主抗真菌免疫
真菌突破宿主血脑屏障的分子机制
肠道与生殖道菌群如何影响真菌感染及宿主免疫
新型抗真菌药物筛选及相关作用机制
真菌耐药的表观遗传调控机制

Publications

Candida Infections: an update on host immune defenses and anti-fungal drugs, Gao, N., and Chen, C., 2016
Passage through the mammalian gut triggers a phenotypic switch required for Candida albicans commensalism, Pande, K., Chen, C. and Noble, S. M., 2013
Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host, Chen, C. and Noble, S. M., 2012
A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis, Chen, C., Pande, K., French, S. D., Tuch, B. B. and Noble, S. M., 2011
Stalled spliceosomes are a signal for RNA-mediated genome defense, Dumesic, P., Natarajan, P., Chen, C., Drinnenberg, A., Schiller, B., Moresco, J., Thompson, J., Yates, J., Bartel, D., and Madhani H., 2013
Systematic gene deletion and analysis of virulence in the human fungal pathogen Cryptococcus neoformans, Liu, O. W., Chun, C. D., Chow, E. D., Chen, C., Madhani, H. D. and Noble, S. M., 2008
Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii, Chen, C. and Dickman, M. B., 2005
Shp2 mediates C-type lectin receptor-induced Syk activation and anti-fungal Th17 responses, Deng Z., Ma S., Zhou H., Zang A., Fang Y., Li T., Shi H., Liu M., Du M., Taylor P., Zhu H., Chen J., Meng G., Li F., Chen C., Zhang Y., Jia X., Lin X., Zhang X., Pearlman E., Li X., Feng G., and Xiao H., 2015
Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2, Xie X., Li F., Wang Y., Lin Z., Cheng X., Liu J., Chen C., and Pan L., 2015
Internalized Cryptococcus neoformans activates the canonical Caspase-1 and the noncanonical Caspase-8 inflammasomes, Chen M., Xing Y., Lu A., Fang W., Sun B., Chen C., Liao W., and Meng G., 2015
Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome, Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G., 2014
A site specific acetylation mark on the essential RSC chromatin remodeling complex promotes resistance to replication stress, Georgette, C., Chen, C., Shih, S., et al., 2011
cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum, Chen, C., and Dickman, M. B., 2005
Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signaling pathways, Chen, C., and Dickman, M. B., 2004
Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichum trifolii, Chen

病原真菌宿主互作白色念珠菌信号通路免疫反应血脑屏障菌群抗真菌药物表观遗传耐药性

孟祥宗 - 上海师范大学

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