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陈显翀
Life Science
中国科学院大学
广东
Language: 英语, 中文
晶型
预测
分子动力学
Gpcr
别构
药物设计
人工智能
筛选
共晶
盐基
Areas of Focus
- 药物晶型预测
- 分子动力学计算
- GPCR别构分子设计
Work Experience
- 2019-09~现在 - 中国科学院深圳先进技术研究院 - 副研究员
- 2016-10~2019-08 - Actmol Limited有限公司 - 首席执行官
- 2012-10~2016-09 - 诺华制药公司 - 博士后
Academic Background & Achievements
- 2009-04--2012-07 博士学位: 布莱德福德大学
- 2009-04--2012-07 硕士学位: 布莱德福德大学
- 2005 学士学位: 香港中文大学
- 成就: 致力于筛选草药活性分子的共晶晶体，以提高分子的水溶性
Publications
- Translocation Mechanism of Allosteric Sodium Ions in β2-Adrenoceptor, Xueying Wang, Shuguang Yuan, Hin Chung Stephen Chan, 2022
- Phase solubility investigation and theoretical calculations on drug-drug cocrystals of carbamazepine with Emodin, Paeonol, Huang, Dandan, Chan, H C Stephen, Wu, Yunshan, Li, Liang, Zhang, Li, Lv, Yang, Yang, Xuemei, Zhou, Zhengzheng, 2021
- Enhancing the Signaling of GPCRs via Orthosteric Ions, H C Stephen Chan, Yueming Xu, Liang Tan, Horst Vogel, Jianjun Cheng, Dong Wu, Shuguang Yuan, 2020
- Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2, Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang, 2020
- New Binding Sites, New Opportunities for GPCR Drug Discovery, Chan, H C Stephen, Li, Yi, Dahoun, Thamani, Vogel, Horst, Yuan, Shuguang, 2019
- Advancing Drug Discovery via Artificial Intelligence, Chan, H C Stephen, Shan, Hanbin, Dahoun, Thamani, Vogel, Horst, Yuan, Shuguang, 2019
- Exploring a new ligand binding site of G protein-coupled receptors, Chan, H C Stephen, Wang, Jingjing, Palczewski, Krzysztof, Filipek, Slawomir, Vogel, Horst, Liu, ZhiJie, Yuan, Shuguang, 2018
- Rationalization of stereoselectivity in enzyme reactions, Chen Xianchong, 2018
- Designing Safer Analgesics via mu-Opioid Receptor Pathways, Chan, H C Stephen, McCarthy, Dillon, Li, Jianing, Palczewski, Krzysztof, Yuan, Shuguang, 2017
- The Principles of Ligand Specificity on beta-2-adrenergic receptor, Chan, H C Stephen, Filipek, Slawomir, Yuan, Shuguang, 2016
