Areas of Focus
- 病原菌感染和天然免疫防御的结构分子机理
Work Experience
- 2018-01~现在 - 中国科学院生物物理研究所 - 研究员
- 2017-01~2017-12 - 中国科学院生物物理研究所 - 项目研究员
- 2012-01~2016-12 - 中国科学院生物物理研究所 - 副研究员
- 2010-11~2011-12 - 中国科学院生物物理研究所 - 助理研究员
- 2008-10~2010-10 - 中国科学院生物物理研究所 - 博士后
Academic Background & Achievements
- 2003-09--2008-06 理学博士: 中国科学院生物物理研究所
- 1999-09--2003-06 理学学士: 武汉大学生命科学学院
Publications
- Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis, 第11作者, 2023
- An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice, 第3作者, 2023
- ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy, 第11作者, 2022
- Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ, 第11作者, 2022
- Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases, 第7作者, 2022
- Structures of heat shock factor trimers bound to DNA, 第11作者, 2021
- Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11, 第12作者, 2021
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells, 第14作者, 2020
- Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis, 第11作者, 2020
- A bioorthogonal system reveals antitumour immune function of pyroptosis, 第3作者, 2020
- Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector, 第11作者, 2019
- A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy, 第14作者, 2019
- Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose, 第14作者, 2018
- Growing a gasdermin pore in membranes of pyroptotic cells, 第11作者, 2018
- Growing a gasdermin pore in membranes of pyroptotic cells