Professor | 刘然 | 数字化转型顾问

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Name	刘然
Contact Information	ran.liu@siat.ac.cn
Language ability	中文, 英语
Province	广东

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Name

刘然

Contact Information

ran.liu@siat.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2016-09--2020-06 博士: 武汉大学 2010-09--2012-06 硕士: 武汉大学 2006-09--2010-06 学士: 四川农业大学
Work Experience	2020-09~现在 - 中国科学院深圳先进技术研究院 - 副研究员 2012-07~2016-08 - 武汉臻智生物科技有限公司 - 研发部经理
Awards	生物基法尼烯为前体合成维生素E的创新工艺, 一等奖, 省级, 2019

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2016-09--2020-06 博士: 武汉大学
2010-09--2012-06 硕士: 武汉大学
2006-09--2010-06 学士: 四川农业大学

Work Experience

2020-09~现在 - 中国科学院深圳先进技术研究院 - 副研究员
2012-07~2016-08 - 武汉臻智生物科技有限公司 - 研发部经理

Awards

生物基法尼烯为前体合成维生素E的创新工艺, 一等奖, 省级, 2019

Areas of Focus	合成生物学代谢工程微生物与疾病的相互关系
Publications	New Insights of Corynebacterium kroppenstedtii in Granulomatous Lobular Mastitis based on Nanopore Sequencing, 第5作者, 2022 3 beta-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males, 第2作者, 2022 构建链霉菌无细胞平台挖掘套索肽类天然产物, 通讯作者, 2022 Evaluation and optimization of analytical procedure and sample preparation for polar Streptomyces albus J1074 metabolome profiling, 第5作者, 2022 Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton, 通讯作者, 2021 The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants, 第2作者, 2021 Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM), 第1作者, 2021 Promising methods for detection of novel coronavirus SARS‐CoV‐2, 第11作者, 2020 A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo, 第1作者, 2020 Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS‐CoV‐2 and Other Respiratory Viruses, 第5作者, 2020 Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007, 第1作者, 2020 Aglycone Polyether Nanchangmycin and Its HomologuesExhibit Apoptotic and Antiproliferative Activities against CancerStem Cells, 第3作者, 2018 Streptomyces species: Ideal chassis for natural product discovery and overproduction, 第1作者, 2018 Modification of epsilon-poly-L-lysine in vivo to reduce self-toxicity and enhance antibiotic overproduction, 第4作者, 2018 Metabolic Engineering of Fatty acyl-ACP Reductase-Dependent Pathway to Improve Fatty Alcohol Production in Escherichia coli., 第1作者, 2013

Areas of Focus

合成生物学
代谢工程
微生物与疾病的相互关系

Publications

New Insights of Corynebacterium kroppenstedtii in Granulomatous Lobular Mastitis based on Nanopore Sequencing, 第5作者, 2022
3 beta-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males, 第2作者, 2022
构建链霉菌无细胞平台挖掘套索肽类天然产物, 通讯作者, 2022
Evaluation and optimization of analytical procedure and sample preparation for polar Streptomyces albus J1074 metabolome profiling, 第5作者, 2022
Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton, 通讯作者, 2021
The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants, 第2作者, 2021
Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM), 第1作者, 2021
Promising methods for detection of novel coronavirus SARS‐CoV‐2, 第11作者, 2020
A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo, 第1作者, 2020
Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS‐CoV‐2 and Other Respiratory Viruses, 第5作者, 2020
Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007, 第1作者, 2020
Aglycone Polyether Nanchangmycin and Its HomologuesExhibit Apoptotic and Antiproliferative Activities against CancerStem Cells, 第3作者, 2018
Streptomyces species: Ideal chassis for natural product discovery and overproduction, 第1作者, 2018
Modification of epsilon-poly-L-lysine in vivo to reduce self-toxicity and enhance antibiotic overproduction, 第4作者, 2018
Metabolic Engineering of Fatty acyl-ACP Reductase-Dependent Pathway to Improve Fatty Alcohol Production in Escherichia coli., 第1作者, 2013

基因工程生物合成代谢途径生物技术微生物工程疾病机制病原体相互作用生化过程细胞生物学生物医学研究

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