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李岩
Life Science
中国科学院大学
北京
Language: 英语, 中文
生物质谱
蛋白质组学
糖组学
临床样品
翻译后修饰
表达调控
人体功能
临床疾病
分析技术
方法开发
Areas of Focus
- 开发以生物质谱为核心的多种蛋白质组学的分析技术和方法
- 发展适用于生物样品和临床样品的新型糖组学的分析技术和方法
- 在蛋白质组学和糖组学分析技术的基础上，主要开展针对蛋白质及其翻译后修饰的表达调控及其在人体功能和临床疾病中的作用机制的研究
Work Experience
- 2011-07 至今 - 中国科学院生物物理研究所 - 研究员
- 2005-10 至 2011-06 - 约翰霍普金斯大学医学院 - 助理研究员/博士后
- 2004-01 至 2005-08 - Calibrant生物技术公司 - 项目主管
- 2000-08 至 2004-05 - 马里兰大学化学与分析化学系 - 研究助理
Academic Background & Achievements
- 2005-10 至 2011-06 博士后: 约翰霍普金斯大学医学院
- 2000-09 至 2004-07 博士: 马里兰大学
- 1994-09 至 1998-07 学士: 北京大学医学部
Publications
- Human milk oligosaccharides in milk of mothers with term and preterm delivery at different lactation stage, Chuncui Huang, Yue Lu, Lin Kong, Zhendong Guo, Keli Zhao, Zheng Xiang, Xinyue Ma, Huanyu Gao, Yongfang Liu, Zhongmin Gao, Lijuan Xu, Wengang Chai, Yan Li, Yao Zhao, 2023
- GIPS-Mix for Accurate Identification of Isomeric Components in Glycan Mixtures Using Intelligent Group-Opting Strategy, Chuncui Huang, Meijie Hou, Jingyu Yan, Wengang Chai, Yan Li, Shiwei Sun, 2023
- Plasma Peptides Modulated by Protease in a Time-Dependent Manner as Effective Biomarkers for Preanalytical Quality Control, Liang Kai, Yan Li, Qianqian Li, Zhijing Song, Keli Zhao, Rong Su, Shengchun Huang, Xueyan Guo, 2023
- Proteomics and post-translational modifications analysis of umbilical mesenchymal stem cells aging, Wang, Junyan, Zhao, Keli, Chen, Ling, Zhou, Jinyu, Sun, Qing, Chen, Junhui, Su, Rong, Li, Yan, 2022
- MALDI–TOF–MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains, Zhang Q. Q, Yan Li, 2022
- A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches, Zou, Wenjun, Huang, Chuncui, Sun, Qing, Zhao, Keli, Gao, Huanyu, Su, Rong, Li, Yan, 2022
- Addition of 3-methoxytyramine or chromogranin A to plasma free metanephrines as the initial test for pheochromocytoma and paraganglioma: Which is the best diagnostic strategy, Liu, Lu, Xie, Wenchun, Song, Zhijing, Wang, Tianyu, Li, Xuesong, Gao, Ying, Li, Yan, Zhang, Junqing, Guo, Xiaohui, 2021
- The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor, Huang, Chuncui, Tan, Zeshun, Zhao, Keli, Zou, Wenjun, Wang, Hui, Gao, Huanyu, Sun, Shiwei, Bu, Dongbo, Chai, Wengang, Li, Yan, 2021
- Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection, Wang, Junyan, Huang, Chuncui, Zhou, Jinyu, Zhao, Keli, Li, Yan, 2021
- Quantitative MALDI-MS assay of steroid hormones in plasma based on hydroxylamine derivatization, Song, Zhijing, Gao, Huanyu, Xie, Wenchun, Sun, Qing, Liang, Kai, Li, Yan, 2021
Awards
- 青年研究员旅行奖 (2010): 一等奖
- 优秀海报奖 (2009): 一等奖
- 青年研究员旅行奖 (2009): 一等奖
