Areas of Focus
- 神经发育调控机制与神经发育性疾病机理
Work Experience
- 2019-01~现在 - 中国科学院昆明动物研究所 - 副研究员
- 2013-07~2018-12 - 中国科学院昆明动物研究所 - 助理研究员
- 2008-09~2013-06 - 中国科学院昆明动物研究所 - 研究生
- 2004-09~2008-06 - 鲁东大学生命科学学院 - 本科生
Academic Background & Achievements
- 2008-09--2013-06 理学博士学位: 中国科学院昆明动物研究所
- 2004-09--2008-06 理学学士学位: 鲁东大学生命科学学院
Publications
- Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma, 第 11 作者, 2023
- Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution, 第 1 作者, 2022
- RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, 第 1 作者, 2022
- Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression, 第 0 作者, 2022
- RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense, 第 2 作者, 2021
- Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse, 第 1 作者, 2021
- RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling, 第 1 作者, 2020
- ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling, 第 1 作者, 2020
- Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development, 第 2 作者, 2020
- Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning, 第 1 作者, 2019
- RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination, 第 9 作者