Professor | 涂然 | 数字化转型顾问

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Name	涂然
Contact Information	tu_r@tib.cas.cn
Language ability	英语, 中文, 德语
Province	天津

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Name

涂然

Contact Information

tu_r@tib.cas.cn

Language ability

英语, 中文, 德语

Province

天津

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2007-04--2010-07 哲学博士: Jacobs University 2001-09--2006-06 理学博士: 中国农业大学 1996-09--2000-06 工学学士: 华南理工大学
Work Experience	2020-08~现在 - 中国科学院天津工业生物技术研究所 - 项目研究员 2014-08~2015-02 - 哈佛大学 - 访问学者 2010-09~现在 - 中国科学院天津工业生物技术研究所 - 副研究员 2006-07~2007-03 - 清华大学 - 博士后研究 2000-09~2001-04 - 北京大学 - 实习研究

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2007-04--2010-07 哲学博士: Jacobs University
2001-09--2006-06 理学博士: 中国农业大学
1996-09--2000-06 工学学士: 华南理工大学

Work Experience

2020-08~现在 - 中国科学院天津工业生物技术研究所 - 项目研究员
2014-08~2015-02 - 哈佛大学 - 访问学者
2010-09~现在 - 中国科学院天津工业生物技术研究所 - 副研究员
2006-07~2007-03 - 清华大学 - 博士后研究
2000-09~2001-04 - 北京大学 - 实习研究

Areas of Focus	高通量筛选技术合成生物学蛋白质工程
Publications	液滴微流控技术在微生物工程菌株选育中的应用进展, 涂然, 2022 Whole-cell biosensor and producer co-cultivation based microfludic platform for screening Saccharopolyspora erythraea with hyper erythromycin production, 涂然, 2022 Recent advances in droplet microfluidics for enzyme and cell factory engineering, 涂然, 2021 Antisense RNA Interference-Enhanced CRISPR/Cas9 Base Editing Method for Improving Base Editing Efficiency in Streptomyces lividans 66, 涂然, 2021 Droplet-based microfluidic platform for high-throughput screening of Streptomyces, 涂然, 2021 A high-throughput fluorescence assay for ketone detection and its applications in enzyme mining and protein engineering, 涂然, 2020 Design and Reconstruction of Regulatory Parts for Fast-frowing Vibrio natriegens Synthetic Biology, 涂然, 2020 High-Throughput Fluorescence Assay for Ketone Detectionand Its Applications in Enzyme Mining and Protein Engineering, 涂然, 2020 Biosensor-enabled droplet microfluidic system for the rapid screening of 3-dehydroshikimic acid produced inEscherichia coli, 涂然, 2020 核黄素工业菌株高通量筛选方法的建立和应用, 涂然, 2020 一种基于微芯片快速生成双层乳化液滴的方法, 涂然, 2020 Rapid isolation of antigen-specific B-cells using droplet microfluidics, 涂然, 2020 Development of a Simple Colorimetric Assay for Determination of the Isoamyl Alcohol-Producing Strain, 涂然, 2020 Genomic, transcriptomic, and metabolic characterizations of Escherichia coli adapted to branched-chain higher alcohol tolerance, 涂然, 2020 Enhanced production of d-psicose 3-epimerase in Bacillus subtilis by regulation of segmented fermentation, 涂然, 2020 A double-enzyme-coupled high-throughput assay for determination of isoamyl alcohol produced by microorganisms, 涂然, 2020 Ultra-high-throughput picoliter-droplet microfluidics screening of the industrial cellulase-producing filamentous fungus Trichoderma reesei, 涂然, 2019 毕赤酵母液滴微流控高通量筛选方法的建立与应用, 涂然, 2019 Development of a Synthetic 3-Dehydroshikimate Biosensor in Escherichia coli for Metabolite Monitoring and Genetic Screening, 涂然, 2019 High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components, 涂然, 2019 Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system, 涂然, 2018 Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system., 涂然, 2017 Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution, 涂然, 2013

Areas of Focus

高通量筛选技术
合成生物学
蛋白质工程

Publications

液滴微流控技术在微生物工程菌株选育中的应用进展, 涂然, 2022
Whole-cell biosensor and producer co-cultivation based microfludic platform for screening Saccharopolyspora erythraea with hyper erythromycin production, 涂然, 2022
Recent advances in droplet microfluidics for enzyme and cell factory engineering, 涂然, 2021
Antisense RNA Interference-Enhanced CRISPR/Cas9 Base Editing Method for Improving Base Editing Efficiency in Streptomyces lividans 66, 涂然, 2021
Droplet-based microfluidic platform for high-throughput screening of Streptomyces, 涂然, 2021
A high-throughput fluorescence assay for ketone detection and its applications in enzyme mining and protein engineering, 涂然, 2020
Design and Reconstruction of Regulatory Parts for Fast-frowing Vibrio natriegens Synthetic Biology, 涂然, 2020
High-Throughput Fluorescence Assay for Ketone Detectionand Its Applications in Enzyme Mining and Protein Engineering, 涂然, 2020
Biosensor-enabled droplet microfluidic system for the rapid screening of 3-dehydroshikimic acid produced inEscherichia coli, 涂然, 2020
核黄素工业菌株高通量筛选方法的建立和应用, 涂然, 2020
一种基于微芯片快速生成双层乳化液滴的方法, 涂然, 2020
Rapid isolation of antigen-specific B-cells using droplet microfluidics, 涂然, 2020
Development of a Simple Colorimetric Assay for Determination of the Isoamyl Alcohol-Producing Strain, 涂然, 2020
Genomic, transcriptomic, and metabolic characterizations of Escherichia coli adapted to branched-chain higher alcohol tolerance, 涂然, 2020
Enhanced production of d-psicose 3-epimerase in Bacillus subtilis by regulation of segmented fermentation, 涂然, 2020
A double-enzyme-coupled high-throughput assay for determination of isoamyl alcohol produced by microorganisms, 涂然, 2020
Ultra-high-throughput picoliter-droplet microfluidics screening of the industrial cellulase-producing filamentous fungus Trichoderma reesei, 涂然, 2019
毕赤酵母液滴微流控高通量筛选方法的建立与应用, 涂然, 2019
Development of a Synthetic 3-Dehydroshikimate Biosensor in Escherichia coli for Metabolite Monitoring and Genetic Screening, 涂然, 2019
High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components, 涂然, 2019
Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system, 涂然, 2018
Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system., 涂然, 2017
Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution, 涂然, 2013

筛选高通量微流控合成生物学蛋白质工程酶生物技术微生物基因工程代谢工程

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