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吴继芹
Life Science
中国科学院大学
湖北
Language: 中文, 英语
Rna病毒
基因组复制
机制
核酸
核苷
药物干预
病毒学
分子生物学
生物化学
病毒复制
Areas of Focus
- RNA病毒基因组复制机制
- 核酸及核苷类药物干预机制
Work Experience
- 2022-10~现在 - 中国科学院武汉病毒研究所 - 青年研究员
- 2021-10~2022-10 - 中国科学院武汉病毒研究所 - 副研究员
- 2020-04~2021-10 - 中国科学院武汉病毒研究所 - 助理研究员
- 2018-05~2020-04 - 中国科学院武汉物理与数学研究所 - 博士后
- 2017-07~2018-05 - 中国科学院武汉病毒研究所 - 实验师
Academic Background & Achievements
- 2012-09--2017-07 博士学位: 中国科学院武汉病毒研究所
- 2008-09--2012-06 学士学位: 中国海洋大学
Publications
- A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase, 吴继芹, 2024
- LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities, 吴继芹, 2023
- Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp, 吴继芹, 2023
- RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature, 吴继芹, 2022
- Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases, 吴继芹, 2022
- Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases, 吴继芹, 2022
- Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex, 吴继芹, 2021
- Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 吴继芹, 2020
- A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase, 吴继芹, 2020
- Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase, 吴继芹, 2018
- A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family, 吴继芹, 2015
- Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation, 吴继芹, 2015
