Professor | 吴继芹 | 数字化转型顾问

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Name	吴继芹
Contact Information	wujiqin@wh.iov.cn
Language ability	中文, 英语
Province	湖北

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Name

吴继芹

Contact Information

wujiqin@wh.iov.cn

Language ability

中文, 英语

Province

湖北

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2012-09--2017-07 博士学位: 中国科学院武汉病毒研究所 2008-09--2012-06 学士学位: 中国海洋大学
Work Experience	2022-10~现在 - 中国科学院武汉病毒研究所 - 青年研究员 2021-10~2022-10 - 中国科学院武汉病毒研究所 - 副研究员 2020-04~2021-10 - 中国科学院武汉病毒研究所 - 助理研究员 2018-05~2020-04 - 中国科学院武汉物理与数学研究所 - 博士后 2017-07~2018-05 - 中国科学院武汉病毒研究所 - 实验师

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2012-09--2017-07 博士学位: 中国科学院武汉病毒研究所
2008-09--2012-06 学士学位: 中国海洋大学

Work Experience

2022-10~现在 - 中国科学院武汉病毒研究所 - 青年研究员
2021-10~2022-10 - 中国科学院武汉病毒研究所 - 副研究员
2020-04~2021-10 - 中国科学院武汉病毒研究所 - 助理研究员
2018-05~2020-04 - 中国科学院武汉物理与数学研究所 - 博士后
2017-07~2018-05 - 中国科学院武汉病毒研究所 - 实验师

Areas of Focus	RNA病毒基因组复制机制核酸及核苷类药物干预机制
Publications	A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase, 吴继芹, 2024 LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities, 吴继芹, 2023 Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp, 吴继芹, 2023 RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature, 吴继芹, 2022 Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases, 吴继芹, 2022 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases, 吴继芹, 2022 Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex, 吴继芹, 2021 Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 吴继芹, 2020 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase, 吴继芹, 2020 Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase, 吴继芹, 2018 A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family, 吴继芹, 2015 Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation, 吴继芹, 2015

Areas of Focus

RNA病毒基因组复制机制
核酸及核苷类药物干预机制

Publications

A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase, 吴继芹, 2024
LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities, 吴继芹, 2023
Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp, 吴继芹, 2023
RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature, 吴继芹, 2022
Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases, 吴继芹, 2022
Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases, 吴继芹, 2022
Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex, 吴继芹, 2021
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 吴继芹, 2020
A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase, 吴继芹, 2020
Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase, 吴继芹, 2018
A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family, 吴继芹, 2015
Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation, 吴继芹, 2015

Rna病毒基因组复制机制核酸核苷药物干预病毒学分子生物学生物化学病毒复制

龚鹏 - 中国科学院大学

汪燕芳 - 同济大学

戴绍军 - 上海师范大学

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