Upload Avatar (500 x 500)
王广川
Life Science
中国科学院大学
上海
Language: 中文, 英语
癌症
免疫系统
治疗
微环境
肿瘤
免疫学
研究
生物学
遗传学
Crispr
Areas of Focus
- 肿瘤免疫学
- 免疫治疗
- 肿瘤微环境
Work Experience
- 2021-01~现在 - 中科院分子细胞科学卓越创新中心 - 研究员
- 2016-05~2021-01 - 耶鲁大学医学院 - 博士后&副研究员
- 2013-09~2016-05 - 浙江大学 - 讲师
Academic Background & Achievements
- 2007-09--2013-06 博士: 浙江大学
- 2003-09--2007-06 学士: 浙江工业大学
Publications
- CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade, 王广川, 2020
- Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity InVivo, 王广川, 2019
- In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens, 王广川, 2019
- Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells., 王广川, 2019
- Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity, 王广川, 2019
- Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening, 王广川, 2018
- AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma (vol 20, pg 1329, 2017), 王广川, 2017
- Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine-silica, 王广川, 2016
- Hydrated Silica Exterior Produced by Biomimetic Silicification Confers Viral Vaccine Heat-Resistance, 王广川, 2015
- Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions, 王广川, 2013
- Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration, 王广川, 2012
- Extracellular Silica Nanocoat Confers Thermotolerance on Individual Cells: A Case Study of Material-Based Functionalization of Living Cells, 王广川, 2010
Awards
- CRI-Irvington博士后奖学金 (2017): 研究所
