Areas of Focus
- 病毒感染与宿主免疫
- 病毒的荧光标记及实时追踪
- 病毒疫苗研发
Work Experience
- 2017-09~现在 - 中国科学院武汉病毒研究所 - 副研究员
- 2014-07~2017-08 - 中国科学院武汉病毒研究所 - 助理研究员
- 2009-09~2014-07 - 中国科学院武汉病毒研究所 - 博士学位
- 2005-09~2009-06 - 武汉大学 - 学士学位
Academic Background & Achievements
- 2009-09--2014-07 博士学位: 中国科学院武汉病毒研究所
- 2005-09--2009-06 学士学位: 武汉大学
Publications
- Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening, 张源, 2022
- Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, 张源, 2021
- A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, 张源, 2020
- Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, 张源, 2020
- Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, 张源, 2020
- In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, 张源, 2020
- Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, 张源, 2020
- Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, 张源, 2019
- ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, 张源, 2018
- Spycatcher-spytag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, 张源, 2018
- Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, 张源, 2018
- The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), 张源, 2018
- An improved method for identifying SUMOylation sites of viral proteins, 张源, 2017
- Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication, 张源, 2017
- Fast and sensitive quantification of protein sumoylation using a dual luciferase biosensor, 张源, 2017
- Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells, 张源, 2017
- SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication, 张源, 2016
- Identification of AcMNPV GP64-binding proteins through a combinational use of a self-biotinylated virus and the cross-linking method, 张源, 2015
- Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking, 张源, 2013
- Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection, 张源, 2013
- One-Pot Synthesized Aptamer-Functionalized CdTe:Zn2+ Quantum Dots for Tumor-Targeted Fluorescence Imaging in Vitro and in Vivo, 张源, 2013
- Differential stepwise evolution of SARS coronavirus functional proteins in different host species, 张源, 2009
