Professor | 张源 | 数字化转型顾问

Name	张源
Contact Information	zhangyuan@wh.iov.cn
Language ability	中文, 英语
Province	湖北

Name

张源

Contact Information

zhangyuan@wh.iov.cn

Language ability

中文, 英语

Province

湖北

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2009-09--2014-07 博士学位: 中国科学院武汉病毒研究所 2005-09--2009-06 学士学位: 武汉大学
Work Experience	2017-09~现在 - 中国科学院武汉病毒研究所 - 副研究员 2014-07~2017-08 - 中国科学院武汉病毒研究所 - 助理研究员 2009-09~2014-07 - 中国科学院武汉病毒研究所 - 博士学位 2005-09~2009-06 - 武汉大学 - 学士学位

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2009-09--2014-07 博士学位: 中国科学院武汉病毒研究所
2005-09--2009-06 学士学位: 武汉大学

Work Experience

2017-09~现在 - 中国科学院武汉病毒研究所 - 副研究员
2014-07~2017-08 - 中国科学院武汉病毒研究所 - 助理研究员
2009-09~2014-07 - 中国科学院武汉病毒研究所 - 博士学位
2005-09~2009-06 - 武汉大学 - 学士学位

Areas of Focus	病毒感染与宿主免疫病毒的荧光标记及实时追踪病毒疫苗研发
Publications	Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening, 张源, 2022 Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, 张源, 2021 A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, 张源, 2020 Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, 张源, 2020 Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, 张源, 2020 In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, 张源, 2020 Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, 张源, 2020 Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, 张源, 2019 ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, 张源, 2018 Spycatcher-spytag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, 张源, 2018 Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, 张源, 2018 The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), 张源, 2018 An improved method for identifying SUMOylation sites of viral proteins, 张源, 2017 Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication, 张源, 2017 Fast and sensitive quantification of protein sumoylation using a dual luciferase biosensor, 张源, 2017 Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells, 张源, 2017 SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication, 张源, 2016 Identification of AcMNPV GP64-binding proteins through a combinational use of a self-biotinylated virus and the cross-linking method, 张源, 2015 Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking, 张源, 2013 Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection, 张源, 2013 One-Pot Synthesized Aptamer-Functionalized CdTe:Zn2+ Quantum Dots for Tumor-Targeted Fluorescence Imaging in Vitro and in Vivo, 张源, 2013 Differential stepwise evolution of SARS coronavirus functional proteins in different host species, 张源, 2009

Areas of Focus

病毒感染与宿主免疫
病毒的荧光标记及实时追踪
病毒疫苗研发

Publications

Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening, 张源, 2022
Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, 张源, 2021
A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, 张源, 2020
Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, 张源, 2020
Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, 张源, 2020
In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, 张源, 2020
Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, 张源, 2020
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, 张源, 2019
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, 张源, 2018
Spycatcher-spytag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, 张源, 2018
Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, 张源, 2018
The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), 张源, 2018
An improved method for identifying SUMOylation sites of viral proteins, 张源, 2017
Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication, 张源, 2017
Fast and sensitive quantification of protein sumoylation using a dual luciferase biosensor, 张源, 2017
Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells, 张源, 2017
SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication, 张源, 2016
Identification of AcMNPV GP64-binding proteins through a combinational use of a self-biotinylated virus and the cross-linking method, 张源, 2015
Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking, 张源, 2013
Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection, 张源, 2013
One-Pot Synthesized Aptamer-Functionalized CdTe:Zn2+ Quantum Dots for Tumor-Targeted Fluorescence Imaging in Vitro and in Vivo, 张源, 2013
Differential stepwise evolution of SARS coronavirus functional proteins in different host species, 张源, 2009

病毒感染宿主免疫荧光标记追踪疫苗研发研究

林昶东 - 同济大学

Area of Focus
细胞粘附 | 信号传导 | 发展 | 感染 | 免疫 | 癌症 | 衰老 | 分子机制 | 病理生理学 | 治疗干预

刘玉乐 - 清华大学

Area of Focus
免疫 | 信号 | 调控 | 病毒 | 病理 | 自噬 | 细胞 | 基因组 | 分子 | 植物

朱永群 - 浙江大学

Area of Focus
病原体 | 宿主 | 免疫 | 信号 | 蛋白质 | 机制 | 菌群 | 结构生物学 | 疾病 | 治疗

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们