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张立国
Life Science
中国科学院大学
北京
Language: 英语, 中文
Hiv
感染
致病机理
免疫反应
Cd4+ T细胞
树突状细胞
人源化小鼠模型
病毒学
免疫学
慢性感染
Areas of Focus
- HIV感染的致病机理
Work Experience
- 2008-10 至今 - 中科院生物物理研究所 - 研究员
- 2000-09 至 2002-07 - 中国预防医学科学院病毒学研究所 - 助理研究员
Academic Background & Achievements
- 2004-11 至 2008-09 博士后: 美国北卡莱罗纳大学教堂山分校
- 2002-07 至 2004-10 博士后: 美国耶鲁大学
- 1997-09 至 2000-07 博士: 中国预防医学科学院病毒学研究所
- 1994-09 至 1997-07 硕士: 南京农业大学
- 1990-09 至 1994-07 学士: 河北农业大学
Publications
- Type 1 interferon contributes to CD4+ T cell depletion in HIV-1 induced human thymus., Journal of Virology, 2011
- Preferential depletion of CD2low plasmacytoid dendritic cells in HIV-infected subjects., Cellular and Molecular Immunology, 2011
- A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease., Gastroenterology, 2011
- Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2-/-gammaC-/- mice in vivo., Blood, 2011
- Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis., Sci China Life Sci, 2010
- Evolution of the HIV-1 env gene in the Rag2-/-gammaC-/- humanized mouse model., Journal of Virology, 2010
- The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env., Journal of Virology, 2009
