Professor | 张立国 | 数字化转型顾问

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Name

张立国

Contact Information

liguozhang@sun5.ibp.ac.cn

Language ability

英语, 中文

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2004-11 至 2008-09 博士后: 美国北卡莱罗纳大学教堂山分校 2002-07 至 2004-10 博士后: 美国耶鲁大学 1997-09 至 2000-07 博士: 中国预防医学科学院病毒学研究所 1994-09 至 1997-07 硕士: 南京农业大学 1990-09 至 1994-07 学士: 河北农业大学
Work Experience	2008-10 至今 - 中科院生物物理研究所 - 研究员 2000-09 至 2002-07 - 中国预防医学科学院病毒学研究所 - 助理研究员

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

Areas of Focus	HIV感染的致病机理
Publications	Type 1 interferon contributes to CD4+ T cell depletion in HIV-1 induced human thymus., Journal of Virology, 2011 Preferential depletion of CD2low plasmacytoid dendritic cells in HIV-infected subjects., Cellular and Molecular Immunology, 2011 A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease., Gastroenterology, 2011 Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2-/-gammaC-/- mice in vivo., Blood, 2011 Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis., Sci China Life Sci, 2010 Evolution of the HIV-1 env gene in the Rag2-/-gammaC-/- humanized mouse model., Journal of Virology, 2010 The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env., Journal of Virology, 2009

Areas of Focus

HIV感染的致病机理

Publications

Type 1 interferon contributes to CD4+ T cell depletion in HIV-1 induced human thymus., Journal of Virology, 2011
Preferential depletion of CD2low plasmacytoid dendritic cells in HIV-infected subjects., Cellular and Molecular Immunology, 2011
A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease., Gastroenterology, 2011
Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2-/-gammaC-/- mice in vivo., Blood, 2011
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis., Sci China Life Sci, 2010
Evolution of the HIV-1 env gene in the Rag2-/-gammaC-/- humanized mouse model., Journal of Virology, 2010
The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env., Journal of Virology, 2009

Hiv 感染致病机理免疫反应 Cd4+ T细胞树突状细胞人源化小鼠模型病毒学免疫学慢性感染

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Area of Focus
病毒 | 感染 | 致病机制 | 抗病毒 | 药物 | 研究 | 机制 | 治疗 | Sars-Cov-2 | Hiv

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