Professor | 毕嘉成 | 数字化转型顾问

Name	毕嘉成
Contact Information	jc.bi@siat.ac.cn
Language ability	中文, 英语
Province	广东

Name

毕嘉成

Contact Information

jc.bi@siat.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2008-09--2014-06 硕博连读: 中国科学技术大学 2004-09--2008-06 学士: 华南理工大学
Work Experience	2018-12~现在 - 中国科学院深圳先进技术研究院 - 副研究员 2016-08~2018-12 - 中国科学院深圳先进技术研究院 - 助理研究员 2014-09~2016-08 - 中国科学院深圳先进技术研究院 - 博士后
Awards	中国免疫学会青年学者奖 (2018): 特等奖, 国家级中国科学院院长优秀奖 (2014): 一等奖, 院级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2008-09--2014-06 硕博连读: 中国科学技术大学
2004-09--2008-06 学士: 华南理工大学

Work Experience

2018-12~现在 - 中国科学院深圳先进技术研究院 - 副研究员
2016-08~2018-12 - 中国科学院深圳先进技术研究院 - 助理研究员
2014-09~2016-08 - 中国科学院深圳先进技术研究院 - 博士后

Awards

中国免疫学会青年学者奖 (2018): 特等奖, 国家级
中国科学院院长优秀奖 (2014): 一等奖, 院级

Areas of Focus	NK细胞的基础免疫学肿瘤免疫学
Publications	Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8(+) T Cells, 毕嘉成, 2023 TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells, 毕嘉成, 2023 合成免疫学与未来NK细胞免疫治疗, 毕嘉成, 2022 CD226: a potent driver of antitumor immunity that needs to be maintained, 毕嘉成, 2021 Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells, 毕嘉成, 2021 Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells, 毕嘉成, 2021 Increased expression of adenosine A3 receptor in tumor-infiltrating NK cells, 毕嘉成, 2021 A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing, 毕嘉成, 2021 TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity, 毕嘉成, 2021 Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis, 毕嘉成, 2020 Molecular Regulation of NK Cell Maturation, 毕嘉成, 2020 IL-33-induced reactive oxygen species are required for optimal metabolic programming in group 2 innate lymphoid cells, 毕嘉成, 2020 Polyglutamine protein in tumor cells sensitizes tumor cells to natural killer cell cytolysis, 毕嘉成, 2020 NK Cell Dysfunction and Checkpoint Immunotherapy, 毕嘉成, 2019 Genetic reprogramming for NK cell cancer immunotherapy with CRISPR/Cas9, 毕嘉成, 2019 NK细胞耗竭与卡控点免疫治疗, 毕嘉成, 2019 Blockade of the checkpoint receptor tigit prevents nk cell exhaustion and elicits potent anti-tumor immunity, 毕嘉成, 2018 Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism, 毕嘉成, 2018 JSI-124 inhibits IgE production in an IgE B cell line., 毕嘉成, 2017 Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice, 毕嘉成, 2017 NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells., 毕嘉成, 2017 NK Cell exhaustion., 毕嘉成, 2017 人IgE-Fc结构域的基因克隆、原核表达及单克隆抗体的制备, 毕嘉成, 2016 T-Cell Ig and ITIM Domain Regulates Natural Killer Cell Activation in Murine Acute Viral Hepatitis, 毕嘉成, 2014 TIGIT Safeguards Liver Regeneration Through Regulating Natural Killer Cell-Hepatocyte Crosstalk, 毕嘉成, 2014

Areas of Focus

NK细胞的基础免疫学
肿瘤免疫学

Publications

Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8(+) T Cells, 毕嘉成, 2023
TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells, 毕嘉成, 2023
合成免疫学与未来NK细胞免疫治疗, 毕嘉成, 2022
CD226: a potent driver of antitumor immunity that needs to be maintained, 毕嘉成, 2021
Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells, 毕嘉成, 2021
Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells, 毕嘉成, 2021
Increased expression of adenosine A3 receptor in tumor-infiltrating NK cells, 毕嘉成, 2021
A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing, 毕嘉成, 2021
TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity, 毕嘉成, 2021
Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis, 毕嘉成, 2020
Molecular Regulation of NK Cell Maturation, 毕嘉成, 2020
IL-33-induced reactive oxygen species are required for optimal metabolic programming in group 2 innate lymphoid cells, 毕嘉成, 2020
Polyglutamine protein in tumor cells sensitizes tumor cells to natural killer cell cytolysis, 毕嘉成, 2020
NK Cell Dysfunction and Checkpoint Immunotherapy, 毕嘉成, 2019
Genetic reprogramming for NK cell cancer immunotherapy with CRISPR/Cas9, 毕嘉成, 2019
NK细胞耗竭与卡控点免疫治疗, 毕嘉成, 2019
Blockade of the checkpoint receptor tigit prevents nk cell exhaustion and elicits potent anti-tumor immunity, 毕嘉成, 2018
Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism, 毕嘉成, 2018
JSI-124 inhibits IgE production in an IgE B cell line., 毕嘉成, 2017
Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice, 毕嘉成, 2017
NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells., 毕嘉成, 2017
NK Cell exhaustion., 毕嘉成, 2017
人IgE-Fc结构域的基因克隆、原核表达及单克隆抗体的制备, 毕嘉成, 2016
T-Cell Ig and ITIM Domain Regulates Natural Killer Cell Activation in Murine Acute Viral Hepatitis, 毕嘉成, 2014
TIGIT Safeguards Liver Regeneration Through Regulating Natural Killer Cell-Hepatocyte Crosstalk, 毕嘉成, 2014

Nk细胞免疫学肿瘤癌症治疗免疫反应细胞生物学分子生物学细胞毒性免疫治疗

董金堂 - 南方科技大学

冯宇亮 - 南方科技大学

刘泉 - 南方科技大学

Area of Focus
肿瘤 | 免疫学 | 免疫治疗 | 神经免疫代谢 | 细胞因子 | Il-33 | 神经递质 | Cgrp | Nmu | Ne | Ilc | Treg | 移植 | 免疫生物学

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