Professor | 韩春生 | 数字化转型顾问

Name	韩春生
Contact Information	hancs@ioz.ac.cn
Language ability	英语, 中文
Province	北京

Name

韩春生

Contact Information

hancs@ioz.ac.cn

Language ability

英语, 中文

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1993-09 至 2000-05 生物化学博士: 密苏里大学 1990-09 至 1993-05 生殖生理学硕士: 中国科学院动物研究所生殖生物学国家重点实验室 1986-09 至 1990-05 遗传学学士: 复旦大学生物工程系
Work Experience	2003-12 至今 - 中国科学院动物研究所 - 研究员 2000-09 至 2013-11 - 美国Lexicon制药公司 - 高级生物信息学科学家

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1993-09 至 2000-05 生物化学博士: 密苏里大学
1990-09 至 1993-05 生殖生理学硕士: 中国科学院动物研究所生殖生物学国家重点实验室
1986-09 至 1990-05 遗传学学士: 复旦大学生物工程系

Work Experience

2003-12 至今 - 中国科学院动物研究所 - 研究员
2000-09 至 2013-11 - 美国Lexicon制药公司 - 高级生物信息学科学家

Areas of Focus	精原干细胞（SSCs）增殖、分化（减数分裂）以及去分化（重编程）精子发生的表观遗传调控机理
Publications	In vivo functions of miRNAs in mammalian spermatogenesis, Chen, Jian, Han, Chunsheng, 2023 Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus, Liu, PeiPei, Lu, ShiPing, Li, Xiao, Tang, GangBin, Liu, Xiao, Dai, ShangKun, Jiao, LinFei, Lin, XiWen, Li, XingGuo, Hu, Baoyang, Jiao, Jianwei, Teng, ZhaoQian, Han, ChunSheng, 刘长梅, 2023 A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency, 李佳宇, 韩春生, 2023 RBFOX2 缺失抑制雄性小鼠的减数分裂起始, 闫琳, 陈建, 宁岩, 韩春生, 2023 Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses, Lu, Cuiling, Qin, Caimeng, Fu, Zheng, Wang, Lina, Yi, Yanxiao, Xin, Mingwei, Zhen, Xiumei, Han, Chunsheng, 2022 MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage, Chen, Jian, Gao, Chenxu, Luo, Mengcheng, Zheng, Chunwei, Lin, Xiwen, Ning, Yan, Ma, Longfei, He, Wei, Xie, Dan, Liu, Kui, Hong, Kai, Han, Chunsheng, 2022 Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis, Ma, Longfei, Xie, Dan, Luo, Mengcheng, Lin, Xiwen, Nie, Hengyu, Chen, Jian, Gao, Chenxu, Duo, Shuguang, Han, Chunsheng, 2022 The male germline-specific protein MAPS is indispensable for pachynema progression and fertility, Li, Miao, Zheng, Jiahuan, Li, Gaopeng, Lin, Zexiong, Li, Dongliang, Liu, Dongteng, Feng, Haiwei, Cao, Dandan, Ng, Ernest H Y, Li, Raymond H W, Han, Chunsheng, Yeung, William S B, Chow, Louise T, Wang, Hengbin, Liu, Kui, 2021 PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications, Dong, Fangfang, Chen, Min, Chen, Min, Jiang, Lin, Shen, Zhiming, Ma, Longfei, Han, Chunsheng, Guo, Xudong, Gao, Fei, 2021 The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis, Chen, Jian, Gao, Chenxu, Lin, Xiwen, Ning, Yan, He, Wei, Zheng, Chunwei, Zhang, Daoqin, Yan, Lin, Jiang, Binjie, Zhao, Yuting, Hossen, Md Alim, Han, Chunsheng, 2021

Areas of Focus

精原干细胞（SSCs）增殖、分化（减数分裂）以及去分化（重编程）
精子发生的表观遗传调控机理

Publications

In vivo functions of miRNAs in mammalian spermatogenesis, Chen, Jian, Han, Chunsheng, 2023
Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus, Liu, PeiPei, Lu, ShiPing, Li, Xiao, Tang, GangBin, Liu, Xiao, Dai, ShangKun, Jiao, LinFei, Lin, XiWen, Li, XingGuo, Hu, Baoyang, Jiao, Jianwei, Teng, ZhaoQian, Han, ChunSheng, 刘长梅, 2023
A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency, 李佳宇, 韩春生, 2023
RBFOX2 缺失抑制雄性小鼠的减数分裂起始, 闫琳, 陈建, 宁岩, 韩春生, 2023
Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses, Lu, Cuiling, Qin, Caimeng, Fu, Zheng, Wang, Lina, Yi, Yanxiao, Xin, Mingwei, Zhen, Xiumei, Han, Chunsheng, 2022
MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage, Chen, Jian, Gao, Chenxu, Luo, Mengcheng, Zheng, Chunwei, Lin, Xiwen, Ning, Yan, Ma, Longfei, He, Wei, Xie, Dan, Liu, Kui, Hong, Kai, Han, Chunsheng, 2022
Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis, Ma, Longfei, Xie, Dan, Luo, Mengcheng, Lin, Xiwen, Nie, Hengyu, Chen, Jian, Gao, Chenxu, Duo, Shuguang, Han, Chunsheng, 2022
The male germline-specific protein MAPS is indispensable for pachynema progression and fertility, Li, Miao, Zheng, Jiahuan, Li, Gaopeng, Lin, Zexiong, Li, Dongliang, Liu, Dongteng, Feng, Haiwei, Cao, Dandan, Ng, Ernest H Y, Li, Raymond H W, Han, Chunsheng, Yeung, William S B, Chow, Louise T, Wang, Hengbin, Liu, Kui, 2021
PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications, Dong, Fangfang, Chen, Min, Chen, Min, Jiang, Lin, Shen, Zhiming, Ma, Longfei, Han, Chunsheng, Guo, Xudong, Gao, Fei, 2021
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis, Chen, Jian, Gao, Chenxu, Lin, Xiwen, Ning, Yan, He, Wei, Zheng, Chunwei, Zhang, Daoqin, Yan, Lin, Jiang, Binjie, Zhao, Yuting, Hossen, Md Alim, Han, Chunsheng, 2021

精原干细胞增殖分化减数分裂去分化重编程表观遗传调控精子发生干细胞

杨哲琼 - 武汉大学

胡宝洋 - 中国科学院大学

韩春生 - 中国科学院大学

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