Areas of Focus
- 靶向抗肿瘤药物研究
- 新型抗体偶联药物研究
Work Experience
- 2015-11~现在 - 中国科学院上海药物研究所 - 研究员
- 2008-10~2009-10 - 瑞士Bern大学 - 博士后
- 2000-07~2015-10 - 中国科学院上海药物研究所 - 研究实习员，助理研究员，副研究员
Academic Background & Achievements
- 2002-08--2007-05 理学博士: 中国科学院上海药物研究所
- 1996-09--2000-05 理学学士: 复旦大学药学院
Publications
- Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer., Oncotarget, 2016
- Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents, Eur. J. Med. Chem., 2016
- Ga(OTf)(3)-promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl alpha-benzotriazolyl-alpha-morpholinoacetate., Rsc Adv, 2015
- Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90, J. Med. Chem., 2014
- An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction, Rsc Adv., 2014
- Synthesis and biological evaluation of 6H-pyrido[2 ',1 ':2,3] imidazo[4,5-c] isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization, Bioorgan Med Chem, 2014
