Professor | 徐田锋 | 数字化转型顾问

Name	徐田锋
Contact Information	tfxu@simm.ac.cn
Language ability	中文, 英语
Province	上海

Name

徐田锋

Contact Information

tfxu@simm.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2009-09--2014-07 博士: 中国科学院广州生物医药与健康研究院 2005-09--2009-06 学士: 山东师范大学
Work Experience	2014-11~2019-02 - 密歇根大学-安娜堡校区 - 博士后 2009-09~2014-07 - 中国科学院广州生物医药与健康研究院 - 研究生/博士 2005-09~2009-06 - 山东师范大学 - 本科/学士
Awards	广东省科学技术奖励 (2016): 二等奖广州市科学技术奖励 (2015): 一等奖

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2009-09--2014-07 博士: 中国科学院广州生物医药与健康研究院
2005-09--2009-06 学士: 山东师范大学

Work Experience

2014-11~2019-02 - 密歇根大学-安娜堡校区 - 博士后
2009-09~2014-07 - 中国科学院广州生物医药与健康研究院 - 研究生/博士
2005-09~2009-06 - 山东师范大学 - 本科/学士

Awards

广东省科学技术奖励 (2016): 二等奖
广州市科学技术奖励 (2015): 一等奖

Areas of Focus	小分子药物设计与合成
Publications	Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC degraders of Oncogenic KRASG12D, 徐田锋, 2024 Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Associate Domain (TEAD) PROTAC Degraders, 徐田锋, 2024 Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers, 徐田锋, 2023 Design, Synthesis, and Bioevaluation of Pyrido2,3-dpyrimidin-7-ones as Potent SOS1 Inhibitors, 徐田锋, 2023 Design, synthesis and structure-activity relationship studies of pyrido2,3-dpyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors, 徐田锋, 2022 Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations, 徐田锋, 2022 Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation, 徐田锋, 2022 Structure-based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction, 徐田锋, 2019 Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction, 徐田锋, 2018 A structure-guided optimization of pyrido2,3-dpyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties, 徐田锋, 2017 C5-substituted pyrido2,3-dpyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant, 徐田锋, 2015 Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as Selective Inhibitors of EGFR Threonine790—Methionine790 (T790M) Mutants., 徐田锋, 2013 Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido4,5-dpyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor Inhibitors with Improved Pharmacokinetic Properties, 徐田锋, 2013 Pyrimido4,5-dpyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine(790) to Methionine(790) (T790M) Mutants, 徐田锋, 2013 Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine(790) -> Methionine(790) Mutant, 徐田锋, 2012

Areas of Focus

小分子药物设计与合成

Publications

Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC degraders of Oncogenic KRASG12D, 徐田锋, 2024
Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Associate Domain (TEAD) PROTAC Degraders, 徐田锋, 2024
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers, 徐田锋, 2023
Design, Synthesis, and Bioevaluation of Pyrido2,3-dpyrimidin-7-ones as Potent SOS1 Inhibitors, 徐田锋, 2023
Design, synthesis and structure-activity relationship studies of pyrido2,3-dpyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors, 徐田锋, 2022
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations, 徐田锋, 2022
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation, 徐田锋, 2022
Structure-based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction, 徐田锋, 2019
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction, 徐田锋, 2018
A structure-guided optimization of pyrido2,3-dpyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties, 徐田锋, 2017
C5-substituted pyrido2,3-dpyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant, 徐田锋, 2015
Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as Selective Inhibitors of EGFR Threonine790—Methionine790 (T790M) Mutants., 徐田锋, 2013
Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido4,5-dpyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor Inhibitors with Improved Pharmacokinetic Properties, 徐田锋, 2013
Pyrimido4,5-dpyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine(790) to Methionine(790) (T790M) Mutants, 徐田锋, 2013
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine(790) -> Methionine(790) Mutant, 徐田锋, 2012

药物设计合成小分子药物化学药理学癌症研究抑制剂 Protac Tead Sos1

蒋白山 - 武汉大学

曾臣 - 南方科技大学

Area of Focus
糖化学 | 糖蛋白 | 多肽 | 药物 | 有机 | 小分子 | 探针 | 合成 | 生物化学 | 化学生物学

董春娥 - 武汉大学

Area of Focus
药物化学 | 合成 | 有机化学 | 碳-杂键 | 不对称催化 | 仿生学 | 离子通道 | 化学合成 | 研究 | 药品

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