Areas of Focus
- 表观遗传学与细胞命运调控
- 红系终末分化中的染色质调控
- CART细胞免疫治疗的分子机制探究
Publications
- CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency, 霍大伟, 赵伟, 李瑞, 龚美涵, 西蒙·西多利, 陆旭坤, 侯玉英, 戴中业, 孔宇, 刘桂芬, 奥勒·N·詹森, 谢伟, 克里斯蒂安·赫林, 熊朝阳, 李国宏, 张勇, 吴旭东, 2022
- JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity, 霍大伟, 陈浩, 程一鸣, 宋欣, 张凯, 李木林, 宣成浩, 2020
- ncHMR detector: a computational framework to systematically reveal nonclassical functions of histone modification regulators, 胡胜根, 霍大伟, 赵伟, 陈玉洁, 刘金, 刘琳, 吴旭东, 张勇, 2020
- An epigenetic circuit controls neurogenic programs during neocortex development, 王安, 王杰, 田凯, 霍大伟, 叶华, 李思, 赵晨, 张博, 郑宇, 徐磊, 华晓, 王凯, 吴秋峰, 吴旭, 曾涛, 刘洋, 周勇, 2021
- mTORC2 regulates hierarchical micro/nano topography-induced osteogenic differentiation via promoting cell adhesion and cytoskeletal polymerization, 高强, 侯玉英, 李志, 胡杰, 霍大伟, 郑浩, 张杰, 姚晓, 高瑞, 吴旭, 隋丽, 2021
- Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis, 陈志, 霍大伟, 李丽, 刘志, 李志, 徐松, 黄勇, 吴伟, 周成, 刘洋, 邝明, 吴峰, 李华, 钱鹏, 宋刚, 吴旭, 陈杰, 侯玉英, 2021
- Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice, 徐磊, 郑宇, 李翔, 王安, 霍大伟, 李强, 王帅, 罗志, 刘洋, 徐峰, 吴旭, 吴明, 周勇, 2021
- Generation and validation of versatile inducible CRISPRi embryonic stem cell and mouse model, 李瑞, 夏晓, 王翔, 孙晓, 戴中业, 霍大伟, 郑浩, 熊辉, 何安, 吴旭, 2020
- PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma, 董飞, 李强, 杨晨, 霍大伟, 王翔, 艾晨, 孔宇, 孙晓, 王伟, 周勇, 刘翔, 李伟, 高伟, 刘伟, 康成, 吴旭, 2018
- Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5, 段勇, 霍大伟, 高杰, 吴浩, 叶志, 刘志, 张凯, 单丽, 周翔, 王勇, 苏东, 丁晓, 史磊, 王勇, 尚勇, 宣成浩, 2016