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张华
Life Science
华中农业大学
湖北
Language: 中文, 英文
基因调控
结核分枝杆菌
耐药性
蛋白质-蛋白质相互作用
蛋白质-核酸相互作用
微生物学
生物化学
分子生物学
病原体
抗生素耐药性
Areas of Focus
- 从蛋白质-蛋白质相互作用及蛋白质-核酸相互作用出发，研究基因调控结核分枝杆菌生长及耐药相关的课题
Work Experience
- 2008-至今 - 华中农业大学生命科学技术学院 - 讲师，副教授
Academic Background & Achievements
- 1994-1998 工学学士学位：湖南农业大学，食品工程
- 2000-2003 理学硕士学位：西南农业大学，微生物学
- 2003-2008 理学博士学位：中国科学院沈阳应用生态研究所，微生物学
Publications
- NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs., Liu Y, Wang H, Cui T, Zhou X, Jia Y, Zhang H*, He ZG*., 2016
- Functional characterization of DnaB helicase and its modulation by single-stranded DNA-binding protein in Mycobacterium tuberculosis., Zhang H, Zhang Z, Yang J, He ZG., 2014
- A novel marRAB operon contributes to the rifampicin resistance in Mycobacterium smegmatis., Zhang H, Gao L, Zhang J, Li W, Yang M, Zhang H, Gao C, He ZG., 2014
- Mycobacterium smegmatis Lsr2 physically and functionally interacts with a new flavoprotein involved in bacterial resistance to oxidative stress., Du Y, Zhang H, He Y, Huang F, He ZG., 2012
- Characterization of amino acid residues essential for tetramer formation and DNA-binding activity of ssDNA-binding protein of Mycobacterium tuberculosis., Zhang H#, Tian Y#, Liu Z, Huang F, Hu L, He ZG., 2011
- Characterization of a bifunctional β-Lactamase/Ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv., Sun L, Zhang L, Zhang H, He ZG., 2011
- Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv., Wang Y, Cui T, Zhang C, Yang M, Huang Y, Li W, Zhang L, Gao C, He Y, Li Y, Huang F, Zeng J, Huang C, Yang Q, Tian Y, Zhao C, Chen H, Zhang H, He ZG., 2010
- The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis., Li Y, Zeng J, Zhang H, He ZG., 2010
- Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules., Yang M, Gao C, Wang Y, Zhang H, He ZG., 2010
- Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of China., Zhang H, Bi L, Li C, Sun Z, Deng J, Zhang XE., 2009
- Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase., Zhang H, Deng J, Bi L, Zhou Y, Zhang Z, Zhang C, Zhang Y. Zhang XE., 2008
Awards
- 2012-2014年：华中农业大学教学质量三等奖
