Professor | 李保界 | 数字化转型顾问

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Name	李保界
Contact Information	libj@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

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Name

李保界

Contact Information

libj@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Bio-X Research Institute
Academic Background & Achievements	1984-1988 学士: 北京师范大学 1992-1994 硕士: Albert Einstein College of Medicine 1992-1997 博士: Albert Einstein College of Medicine 1997-2001 博士后: HHMI, Columbia University 长江学者特聘教授上海市千人计划特聘教授
Work Experience	回国之前 - 新加坡分子与细胞生物学研究所 - 主要研究员（助理教授、副教授）现任 - 上海交通大学Bio-X研究院 - 副院长及干细胞与发育研究中心主任

University/Lab Affiliation and Title

上海交通大学

Faculty

Bio-X Research Institute

Academic Background & Achievements

1984-1988 学士: 北京师范大学
1992-1994 硕士: Albert Einstein College of Medicine
1992-1997 博士: Albert Einstein College of Medicine
1997-2001 博士后: HHMI, Columbia University
长江学者特聘教授
上海市千人计划特聘教授

Work Experience

回国之前 - 新加坡分子与细胞生物学研究所 - 主要研究员（助理教授、副教授）
现任 - 上海交通大学Bio-X研究院 - 副院长及干细胞与发育研究中心主任

Areas of Focus	间充质干细胞体内自我更新、分化以及衰老的调控机制骨骼发育、骨代谢以及骨质疏松症的发病机理 DNA损伤应激反应、衰老以及肿瘤发生
Publications	S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response., Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li, 2010 Atypical Atm-p53 interaction in osteogenesis is mediated by Smad1 signaling., Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li, 2012 A crucial role for BMP-Smad1 signaling in the DNA damage response., Jenny Chau, Yuanyu Hu, Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li, 2012 c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression., Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, and Baojie Li, 2012 p53 regulates neural stem cell self-renewal and differentiation via BMP-Smad1-Id1 pathway., Huijuan Liu, Deyong Jia, Jenny Chau, Lin He and Baojie Li, 2013 A critical role for p57Kip2 in the DNA damage response., Hao Jia, Jenny Fang Ling Chau, Qian Cong, and Baojie Li, 2014 Ablation of Tak1 in monocyte leads to defects in skeletal growth and bone remodeling in mice., Bing Qi, Qian Cong, Ping Li, Gang Ma, Xizhi Guo, Min Xie, Michael D. Schneider, Huijuan Liu, and Baojie Li, 2014 p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers., Xinsen Ruan, Qiao Zuo, Jenny Chua, Hao Jia, Jinlin Lin, Xuechun Xia, Huijuan Liu, Samy L. Habib, Chuangang Fu, and Baojie Li, 2015

Areas of Focus

间充质干细胞体内自我更新、分化以及衰老的调控机制
骨骼发育、骨代谢以及骨质疏松症的发病机理
DNA损伤应激反应、衰老以及肿瘤发生

Publications

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response., Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li, 2010
Atypical Atm-p53 interaction in osteogenesis is mediated by Smad1 signaling., Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li, 2012
A crucial role for BMP-Smad1 signaling in the DNA damage response., Jenny Chau, Yuanyu Hu, Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li, 2012
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression., Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, and Baojie Li, 2012
p53 regulates neural stem cell self-renewal and differentiation via BMP-Smad1-Id1 pathway., Huijuan Liu, Deyong Jia, Jenny Chau, Lin He and Baojie Li, 2013
A critical role for p57Kip2 in the DNA damage response., Hao Jia, Jenny Fang Ling Chau, Qian Cong, and Baojie Li, 2014
Ablation of Tak1 in monocyte leads to defects in skeletal growth and bone remodeling in mice., Bing Qi, Qian Cong, Ping Li, Gang Ma, Xizhi Guo, Min Xie, Michael D. Schneider, Huijuan Liu, and Baojie Li, 2014
p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers., Xinsen Ruan, Qiao Zuo, Jenny Chua, Hao Jia, Jinlin Lin, Xuechun Xia, Huijuan Liu, Samy L. Habib, Chuangang Fu, and Baojie Li, 2015

干细胞自我更新分化衰老骨骼发育骨代谢骨质疏松 Dna损伤肿瘤发生调控机制

刘慧娟 - 上海交通大学

Area of Focus
干细胞 | 自我更新 | 分化 | 衰老 | 调控 | 间充质 | Dna损伤 | 肿瘤发生 | 应激反应 | 机制

夏学春 - 上海交通大学

李小勇 - 上海交通大学

Area of Focus
生殖 | 生理 | 生殖系 | 干细胞 | 女性 | 增殖 | 自我更新 | 胚胎发育 | 毒理检测 | Dna甲基化

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