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顾云燕
guyunyan@ems.hrbmu.edu.cn
中文, 英语
黑龙江
哈尔滨医科大学
College of Bioinformatics Science and Technology
  • 2003.9-2007.7 基础医学学士:哈尔滨医科大学
  • 2007.9-2011.6 生物物理学(生物信息方向)博士:哈尔滨医科大学
  • 发表研究论文60余篇,其中第一/通讯作者30篇
  • 黑龙江省科学技术奖三等奖获得者
  • 黑龙江省医药卫生科学技术二等奖获得者
  • 2011.7-2012.8 计算系统生物学讲师:哈尔滨医科大学
  • 2012.9-2017.8 计算系统生物学副教授:哈尔滨医科大学
  • 2017.9-至今 计算系统生物学教授:哈尔滨医科大学
  • 2020年6月:黑龙江省医药卫生科学技术二等奖
  • 2017年10月:黑龙江省科学技术奖三等奖
  • 2017年3月:哈尔滨医科大学青年科技人才奖
  • 2016年11月:哈尔滨市科学技术进步三等奖
  • 2016年10月:哈尔滨医科大学“三育人”工作先进个人
复杂疾病的生物信息学
癌症基因组学
药物耐药机制
  • Identification of mutational signature for lung adenocarcinoma prognosis and immunotherapy prediction, Sainan Zhang, Mengyue Li, Yilong Tan, Juxuan Zhang, Yixin Liu, Wenbin Jiang, Xin Li, Haitao Qi, Lefan Tang, Ran Ji, Wenyuan Zhao, Yunyan Gu, Lishuang Qi, 2022
  • A genetic map of the chromatin regulators to drug response in cancer cells, Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi, Yunyan Gu, 2022
  • Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade, Tingting Chen, Tong Yu, Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu, Yunyan Gu, 2022
  • Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma, Kaidong Liu, Yiding Geng, Linzhu Wang, Huanhuan Xu, Min Zou, Yawei Li, Zhangxiang Zhao, Tingting Chen, Fengyan Xu, Liang Sun, Shuliang Wu, Yunyan Gu, 2022
  • StemSC: a cross-dataset human stemness index for single-cell samples, Hailong Zheng, Jiajing Xie, Kai Song, Jing Yang, Huiting Xiao, Jiashuai Zhang, Keru Li, Rongqiang Yuan, Yuting Zhao, Yunyan Gu, Wenyuan Zhao, 2022
  • Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment, Chengyu Wang, Tong Zhu, Zhangxiang Zhao, Bo Chen, Tingting Chen, Qi Dong, Mingyue Liu, Shuping Zhuang, Fan Yang, Yaoyao Liu, Min Yang, Yunyan Gu, Haihai Liang, 2022
  • A transcriptional signature detects homologous recombination deficiency in pancreatic cancer at the individual level, Shuping Zhuang, Tingting Chen, Yawei Li, Yuquan Wang, Liqiang Ai, Yiding Geng, Min Zou, Kaidong Liu, Huanhuan Xu, Linzhu Wang, Zhangxiang Zhao, Zhiqiang Chang, Yunyan Gu, 2021
  • Discovering a qualitative transcriptional signature of homologous recombination defectiveness for prostate cancer, Yawei Li, Zhangxiang Zhao, Liqiang Ai, Yuquan Wang, Kaidong Liu, Bo Chen, Tingting Chen, Shuping Zhuang, Huanhuan Xu, Min Zou, Yunyan Gu, Xia Li, 2021
  • Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome, Qi Dong, Mingyue Liu, Bo Chen, Zhangxiang Zhao, Tingting Chen, Chengyu Wang, Shuping Zhuang, Yawei Li, Yuquan Wang, Liqiang Ai, Yaoyao Liu, Haihai Liang, Lishuang Qi, Yunyan Gu, 2021
  • Individualized lncRNA differential expression profile reveals heterogeneity of breast cancer, Zhangxiang Zhao, YingYing Guo, Yaoyao Liu, Lichun Sun, Bo Chen, Chengyu Wang, Tingting Chen, Yuquan Wang, Yawei Li, Qi Dong, Liqiang Ai, Ran Wang, Yunyan Gu, Xia Li, 2021
  • LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation, Tingting Chen, Yingying Guo, Jiayi Wang, Liqiang Ai, Lu Ma, Wenxin He, Zhixin Li, Xiaojiang Yu, Jinrui Li, Xingxing Fan, Yunyan Gu, Haihai Liang, 2021
  • An individualized transcriptional signature to predict the epithelial-mesenchymal transition based on relative expression ordering, Tingting Chen, Zhangxiang Zhao, Bo Chen, Yuquan Wang, Fan Yang, Chengyu Wang, Qi Dong, Yaoyao Liu, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Yan Xu, Yunyan Gu, 2020
  • A PTAL-miR-101-FN1 axis promotes EMT and invasion-metastasis in serous ovarian cancer, Haihai Liang, Mengxue Yu, Rui Yang, Lu Zhang, Lijia Zhang, Di Zhu, Hongwei Luo, Yaozhen Hong, Tong Yu, Jian Sun, Hongli Shan, Yunyan Gu, 2019
  • RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome, Chengyu Wang, Fan Yang, Tingting Chen, Qi Dong, Zhangxiang Zhao, Yaoyao Liu, Bo Chen, Haihai Liang, Huike Yang, Yunyan Gu, 2019
  • Genetic interactions-based biomarkers identification for drug resistance and sensitivity in cancer cells, Yue Han, Chengyu Wang, Qi Dong, Tingting Chen, Fan Yang, Yaoyao Liu, Bo Chen, Zhangxiang Zhao, Lishuang Qi, Wenyuan Zhao, Haihai Liang, Zheng Guo, Yunyan Gu, 2019
  • Link synthetic lethality to drug sensitivity of cancer cells, Ruiping Wang, Yue Han, Zhangxiang Zhao, Fan Yang, Ya Han, Tingting Chen, Xianlong Wang, Lishuang Qi, Wenyuan Zhao, Zheng Guo, Yunyan Gu, 2019
  • LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression, Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianiyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu, 2018
  • A landscape of synthetic viable interactions in cancer, Yunyan Gu, Ruiping Wang, Yue Han, Wenbin Zhou, Zhangxiang Zhao, Tingting Chen, Yuanyuan Zhang, Fuduan Peng, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Da Yang, Zheng Guo, 2018
  • Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer, Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu, Hongli Shan, 2018
  • Identification of driver copy number alterations in diverse cancer types and application in drug repositioning, Wenbin Zhou, Zhangxiang Zhao, Ruiping Wang, Yue Han, Chengyu Wang, Fan Yang, Ya Han, Haihai Liang, Lishuang Qi, Chenguang Wang, Zheng Guo, Yunyan Gu, 2017
  • Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma, Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo, Yunyan Gu, 2017
  • EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network, Zhangxiang Zhao, Wenbin Zhou, Yue Han, Fuduan Peng, Ruiping Wang, Ruihan Yu, Chengyu Wang, Haihai Liang, Zheng Guo, Yunyan Gu, 2017
  • Identification of differentially expressed miRNAs in individual breast cancer patient and application in personalized medicine, Fuduan Peng, Yuanyuan Zhang, Ruiping Wang, Wenbin Zhou, Zhangxiang Zhao, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Hongwei Wang, Chenguang Wang, Zheng Guo, Yunyan Gu, 2016
  • Autophagy-related prognostic signature for breast cancer, Yunyan Gu, Pengfei Li, Fuduan Peng, Mengmeng Zhang, Yuanyan Zhang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Hongwei Wang, Chenguang Wang, Zheng Guo, 2016
  • The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2, Yunyan Gu, Mengmeng Zhang, Fuduan Peng, Lei Fang, Yuanyuan Zhang, Haihai Liang, Wenbin Zhou, Lu Ao, Zheng Guo, 2015
  • Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis, Haihai Liang, Yunyan Gu, Tianyu Li, Ying Zhang, Longtao Huangfu, Meiyu Hu, Dandan Zhao, Yang Chen, Shanshan Liu, Yuechao Dong, Li Xuelian, Lu Yanjie, Yang Baofeng, Shan Hongli, 2014
  • Network analysis of genomic alteration profiles reveals co-altered functional modules and driver genes for glioblastoma, Yunyan Gu, Hongwei Wang, Yao Qin, Yujing Zhang, Wenyuan Zhao, Lishuang Qi, Yuannv Zhang, Chenguang Wang, Zheng Guo, 2013
  • Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways, Yunyan Gu, Wenyuan Zhao, Jiguang Xia, Yuannv Zhang, Ruihong Wu, Chenguang Wang, Zheng Guo, 2011
  • Systematic interpretation of comutated genes in large-scale cancer mutation profiles, Yunyan Gu, Da Yang, Jinfeng Zou, Wencai Ma, Ruihong Wu, Wenyuan Zhao, Yuannv Zhang, Hui Xiao, Xue Gong, Min Zhang, Zhu Jing, Zheng Guo, 2010
  • 研究乳腺癌个体中差异表达lncRNA的研究, 顾云燕,郭政,赵文媛,杨凡,韩月, 2017
生物信息学 复杂疾病 癌症 基因组学 药物耐药 肿瘤 纤维化 数据分析 遗传互作 组学

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