Professor | 郑直 | 数字化转型顾问

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Name	郑直
Contact Information	zhizheng100@126.com
Language ability	英语, 中文
Province	北京

Upload Avatar (500 x 500)

Name

郑直

Contact Information

zhizheng100@126.com

Language ability

英语, 中文

Province

北京

University/Lab Affiliation and Title	北京协和医学院
Faculty	Basic Medical Sciences
Academic Background & Achievements	1988年 - 化学学士学位：北京大学 1997年 - 神经分子生物学博士学位：康奈尔大学博士后研究：斯坦福大学医学院血液科
Work Experience	1997-2000 - 斯坦福大学医学院 - 博士后研究员 2000-2007 - 美国生物技术公司 - 基因检测技术开发 2007年至今 - 中国医学科学院基础医学研究所/北京协和医学院基础学院教授
Awards	斯坦福大学医学院院长奖学金 NIH博士后奖学金（NRSA） 2007年 - 美国临床化学学会北加州分会临床化学杰出科技贡献奖

University/Lab Affiliation and Title

北京协和医学院

Faculty

Basic Medical Sciences

Academic Background & Achievements

1988年 - 化学学士学位：北京大学
1997年 - 神经分子生物学博士学位：康奈尔大学
博士后研究：斯坦福大学医学院血液科

Work Experience

1997-2000 - 斯坦福大学医学院 - 博士后研究员
2000-2007 - 美国生物技术公司 - 基因检测技术开发
2007年至今 - 中国医学科学院基础医学研究所/北京协和医学院基础学院教授

Awards

斯坦福大学医学院院长奖学金
NIH博士后奖学金（NRSA）
2007年 - 美国临床化学学会北加州分会临床化学杰出科技贡献奖

Areas of Focus	将先进生物技术应用于临床医学与诊断对传染病大规模高通量、高灵敏快速筛查所需新技术的研究精准医学及个性化医疗临床检测所需生物标记物的发现及其大规模高通量检测
Publications	A direct, sensitive and high-throughput genus- and species-specific molecular assay for large-scale malaria screening, Zhao YL, Zhao Y, Sun Y, Fan L, Wang D, Wang H, Sun X, Zheng Z, 2022 Photothermal Mediated Rolling Circle Amplification Toward Specific and Direct In Situ mRNA Detection, Liu D, Li W, Yang M, Qu L, Pian H, Huang Y, Cheng M, Zheng Z, 2021 GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma, Dong, Y., Huang, Y., Fan, C. Wang L, Zhang R, Li W, Guo, Z; Wang D, Zheng, Z, 2021 Effectiveness of joint 3 + 1 malaria strategy along China–Myanmar cross border areas, Lin Z, Li S, Sun X, Zheng Z, Yang J, Pian H, Tian P, Chen Q, Sun X, Ding C, Duan K, Chen H, Bee DY, Zhou H, 2021 High-throughput, Multiplex Genotyping Directly from Blood or Dried Blood Spot without DNA Extraction for the Screening of Multiple G6PD Gene Variants at Risk for Drug-induced Hemolysis, Tian, X, Zhou, J, Zhao, Y., Cheng, Z., Song, W., Sun, Y., Sun, X., and Zheng, Z, 2017 Direct RNA detection without nucleic acid purification and PCR: Combining sandwich hybridization with signal amplification based on branched hybridization chain reaction, Xu Y and Zheng Z, 2016 Capture Ligation Probe-PCR (CLIP-PCR) for Molecular Screening, with Application to Active Malaria Surveillance for Elimination, Cheng Z, Wang D, Tian X, Sun Y, Sun X, Xiao N, Zheng Z, 2015 Quantitative survey of multiple CpGs from 5 genes identifies CpG methylation panel discriminating between high- and low-grade cervical intraepithelial neoplasia, Tian X, Chen D, Zhang R, Zhou J, Peng X, Yang X, Zhang X, Zheng Z, 2015 A paper-based skin patch for the diagnostic screening of cystic fibrosis, Mu X, Xin X, Fan C, Li X, Tian X, Xu K, Zheng Z, 2015 Multiplex Microfluidic Paper-based Immunoassay for the Diagnosis of Hepatitis C Virus Infection, Mu M, Zhang L, Chang S, Cui W and Zheng Z, 2014 Oil-water biphasic parallel flow for the precise patterning of metals and cells, Mu X, Liang Q, Zhou J, Ren K, Hu P, Wang Y, Zheng Z, Luo G, 2014 A Novel, Sensitive Assay for High-Throughput Molecular Detection of Plasmodia for Active Screening of Malaria for Elimination, Cheng, Z, Sun, X, Yang, Y, Wang, H and Zheng, Z, 2013 Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood, Ran R, Li L, Wang M, Wang S, Zheng Z, Lin PP, 2013 Sensitive and Quantitative Measurement of Gene Expression Directly from Small Amount of Whole Blood, Zheng, Z, Luo, Y., and McMaster, GK, 2006 蝎形探针扩增阻滞突变系统检测肺癌患者血清与肿瘤组织中表皮生长因子受体基因突变, 周南，李龙芸，郑直，李单青，崔巍，翁姗姗，王孟昭，王树兰，钟巍, 2011 晚期非小细胞肺癌患者使用EGFR-TKI治疗后长期生存的研究, 管慧,李龙芸,王孟昭,王树兰,韩如冰,钟巍,冉然,周京伟,郑直, 2011 抑癌基因甲基化位点定量检测在宫颈癌早期诊断中的意义探讨, 张秀茹;陈迪;田晓怡;郑直, 2012 无需逆转录的高通量多重呼吸道病毒RNA检测技术的建立, 杨丹丽，田晓怡，石伟先，郑直, 2013 基于金属增强荧光的高通量碱基突变的筛查, 徐瑶，郑直, 2014 同步原位检测CTC多重瘤标蛋白表达与染色体异倍体的意义, 由磊，赵烨，阚秀，李一林，王东民，张爱群，王红霞，刘颖，王丹丹，林平，郑直, 2017

Areas of Focus

将先进生物技术应用于临床医学与诊断
对传染病大规模高通量、高灵敏快速筛查所需新技术的研究
精准医学及个性化医疗临床检测所需生物标记物的发现及其大规模高通量检测

Publications

A direct, sensitive and high-throughput genus- and species-specific molecular assay for large-scale malaria screening, Zhao YL, Zhao Y, Sun Y, Fan L, Wang D, Wang H, Sun X*, Zheng Z*, 2022
Photothermal Mediated Rolling Circle Amplification Toward Specific and Direct In Situ mRNA Detection, Liu D, Li W, Yang M, Qu L, Pian H, Huang Y, Cheng M, Zheng Z*, 2021
GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma, Dong, Y., Huang, Y., Fan, C. Wang L, Zhang R, Li W, Guo, Z*; Wang D*, Zheng, Z*, 2021
Effectiveness of joint 3 + 1 malaria strategy along China–Myanmar cross border areas, Lin Z, Li S, Sun X*, Zheng Z*, Yang J, Pian H, Tian P, Chen Q, Sun X, Ding C, Duan K, Chen H, Bee DY, Zhou H*, 2021
High-throughput, Multiplex Genotyping Directly from Blood or Dried Blood Spot without DNA Extraction for the Screening of Multiple G6PD Gene Variants at Risk for Drug-induced Hemolysis, Tian, X, Zhou, J, Zhao, Y., Cheng, Z., Song, W., Sun, Y., Sun, X*., and Zheng, Z*, 2017
Direct RNA detection without nucleic acid purification and PCR: Combining sandwich hybridization with signal amplification based on branched hybridization chain reaction, Xu Y and Zheng Z*, 2016
Capture Ligation Probe-PCR (CLIP-PCR) for Molecular Screening, with Application to Active Malaria Surveillance for Elimination, Cheng Z, Wang D, Tian X, Sun Y, Sun X*, Xiao N*, Zheng Z*, 2015
Quantitative survey of multiple CpGs from 5 genes identifies CpG methylation panel discriminating between high- and low-grade cervical intraepithelial neoplasia, Tian X, Chen D, Zhang R, Zhou J, Peng X, Yang X*, Zhang X*, Zheng Z*, 2015
A paper-based skin patch for the diagnostic screening of cystic fibrosis, Mu X*, Xin X, Fan C, Li X, Tian X*, Xu K, Zheng Z*, 2015
Multiplex Microfluidic Paper-based Immunoassay for the Diagnosis of Hepatitis C Virus Infection, Mu M*, Zhang L, Chang S, Cui W and Zheng Z*, 2014
Oil-water biphasic parallel flow for the precise patterning of metals and cells, Mu X, Liang Q*, Zhou J, Ren K, Hu P, Wang Y, Zheng Z*, Luo G*, 2014
A Novel, Sensitive Assay for High-Throughput Molecular Detection of Plasmodia for Active Screening of Malaria for Elimination, Cheng, Z, Sun, X, Yang, Y, Wang, H and Zheng, Z*, 2013
Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood, Ran R, Li L*, Wang M, Wang S, Zheng Z*, Lin PP, 2013
Sensitive and Quantitative Measurement of Gene Expression Directly from Small Amount of Whole Blood, Zheng, Z*, Luo, Y., and McMaster, GK, 2006
蝎形探针扩增阻滞突变系统检测肺癌患者血清与肿瘤组织中表皮生长因子受体基因突变, 周南，李龙芸*，郑直*，李单青，崔巍，翁姗姗，王孟昭，王树兰，钟巍, 2011
晚期非小细胞肺癌患者使用EGFR-TKI治疗后长期生存的研究, 管慧,李龙芸*,王孟昭,王树兰,韩如冰,钟巍,冉然,周京伟,郑直*, 2011
抑癌基因甲基化位点定量检测在宫颈癌早期诊断中的意义探讨, 张秀茹;陈迪;田晓怡;郑直*, 2012
无需逆转录的高通量多重呼吸道病毒RNA检测技术的建立, 杨丹丽，田晓怡，石伟先，郑直*, 2013
基于金属增强荧光的高通量碱基突变的筛查, 徐瑶，郑直*, 2014
同步原位检测CTC多重瘤标蛋白表达与染色体异倍体的意义, 由磊，赵烨，阚秀，李一林，王东民，张爱群，王红霞，刘颖，王丹丹，林平，郑直*, 2017

生物技术临床医学诊断传染病高通量灵敏度筛查生物标记物精准医学个性化医疗

周林福 - 浙江大学

Area of Focus
传染病 | 诊断 | 治疗 | 医学研究 | 病原体 | 病毒学 | 细菌学 | 流行病学 | 临床试验 | 公共卫生

王兰翠 - 复旦大学

宋武慧 - 复旦大学

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