Areas of Focus
- 脑衰老和阿尔茨海默病的分子细胞机制探索
- 大脑脂代谢在神经退行性疾病以及衰老过程中的作用机制研究
- 表观遗传调控在学习记忆中的作用机制解析
Work Experience
- 博士后研究 - 华盛顿大学医学院
- 博士后研究 - 宾夕法尼亚大学医学院
- 副主任 - 中科院脑功能与脑疾病重点实验室
- 副主任 - 衰老生物医学安徽省重点实验室
Academic Background & Achievements
- 2005 - 博士: 中国科学院生物物理研究所
- 国家杰出青年科学基金获得者(2021)
- 国家创新人才计划(2012)
- 国家优秀青年科学基金获得者(2014)
- 中科院动物进化与遗传前沿交叉卓越创新中心骨干(2019)
Publications
- Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization., Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q., 2024
- Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment., Li D, Cao R, Li Q, Yang Y, Tang A, Zhang J, Liu Q., 2023
- Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone acetylation-mediated memory., Li XH, Zhang J, Li DF, He C, He K, Xue T, Wan L, Zhang C and Liu Q., 2021
- Brain cell type-specific cholesterol metabolism and implications for learning and memory., Li D, Zhang J, Liu Q., 2022
- Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation., Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q., 2018
- SFRS11 loss leads to aging-associated cognitive decline by modulating LRP8 and ApoE., Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q., 2019
- Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing., Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q., 2021
- Age- and disease-related memory decline: epigenetic biomarker and treatment., Zhang J, Liu Q., 2023
- Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain., Zhang J, Li D, He K, Liu Q*, Xie Z*., 2024
- Mechanistic insights on non-coding RNAs in learning and memory., Li D, Zhang J, Liu Q., 2023
- Cholesterol metabolism and homeostasis in the brain., Zhang J, Liu Q., 2015
Awards
- 国家杰出青年科学基金获得者(2021)
- 国家创新人才计划(2012)
- 国家优秀青年科学基金获得者(2014)