Areas of Focus
- 髓鞘形成胶质细胞发育和疾病的分子机制
- 表观遗传学和染色质重塑调控髓鞘细胞分化和疾病
- 神经胶质细胞分化和再生的信号机制
Work Experience
- 2007-2012年 - 德克萨斯大学西南医学中心 - 博士后
- 2013年至今 - 厦门大学生命科学学院 - 教授
Academic Background & Achievements
- 1996年 - 生物化学学士: 复旦大学
- 1999年 - 病原生物学硕士: 中国预防医学科学院
- 2006年 - 免疫与微生物学博士: 美国拉什大学
Publications
- A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism., Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR, Zhao TJ, Chen Y., 2019
- Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination., Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y., 2016
- Olig2 Targets Chromatin Remodelers To Enhancers To Initiate Oligodendrocyte Differentiation., Yu Y, Y. Chen, B. Kim, H. Wang, C. Zhao, X. He, L. Liu, W. Liu, L. M. N. Wu, M. Mao, J. R. Chan, J. Wu and Q. R. Lu, 2013
- HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination., Ying Chen, Haibo Wang, Sung Ok Yoon, Xiaomei Xu, Michael Hottiger, Haesun Kim, Eric N. Olson, and Q. Richard Lu., 2011
- The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination., Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu., 2009
- The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury., Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR., 2008