Areas of Focus
- 磷脂酶C及相关信号分子在细胞生命活动中的调节机制
Work Experience
- 1990.07-1997.07 - 兰州大学医学院 - 组织学与胚胎学助教
- 1993.08-1998.07 - 兰州大学医学院 - 组织学与胚胎学讲师
- 1998.08-1998.12 - 兰州大学医学院 - 组织学与胚胎学副教授
- 1998.12-2008.07 - 厦门大学医学院 - 基础医学部副教授
- 2008.08-至今 - 厦门大学医学院 - 基础医学部教授
Academic Background & Achievements
- 1983.09–1987.07 学士: 辽宁师范大学, 生物系
- 1987.09–1990.07 硕士: 兰州大学医学院, 组织学与胚胎学
- 2000.09–2006.12 博士: 厦门大学, 动物学
Publications
- Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma., Bingchang Zhang, Fen Wang, Lianzhi Dai, Heguo Cai, Yanyan Zhan, Gang Song, Tianhui Hu, Chun Xia (corresponding), Bing Zhang (corresponding), 2016
- Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1., Cui X, Wang S, Cai H, Lin Y, Zheng X, Zhang B (corresponding), Xia C (corresponding), 2016
- DAG/PKCδ and IP3/Ca(2+)/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway., Lianzhi Dai, Luhua Zhuang, Bingchang Zhang, Fen Wang, Xiaolei Chen, Chun Xia (corresponding), Bing Zhang (corresponding), 2015
- The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes., Zejun Liu, Heguo Cai, Xinpeng Zheng, Bing Zhang (corresponding), Chun Xia (corresponding), 2015
- Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells., Tingting Yi, Luhua Zhuang, Gang Song, Guideng Li, Bing Zhang (corresponding), Tianhui Hu, 2015
- Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase γ1 expression., Luhua Zhuang, Bingchang Zhang, Guoqing Zeng, Lianzhi Dai, Hongliu Qian, Tianhui Hu, Gang Song, Bing Zhang (corresponding), Chun Xia (corresponding), 2014
- Disruption of phosphoinositide-specific phospholipases Cγ1 contributes to extracellular matrix synthesis of human osteoarthritis chondrocytes., Zeng G, Cui X, Liu Z, Zhao H, Zheng X, Zhang B (corresponding), Xia C (corresponding), 2014
- Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling., Zhao H, Zhang T, Xia C (corresponding), Shi L, Wang S, Zheng X, Hu T, Zhang B (corresponding), 2014
- 12-O-tetradecanoylphorbol-1,3-acetate-induced degradation of protein kinase B via ubiquitin-proteasomal pathway depends on its Ser473 phosphorylation in gastric cancer cells., Zhang B, Xia C (corresponding), 2013
- Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes., Chen Q, Zhang B (corresponding), Yi T, Xia C (corresponding), 2012
- Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis., Zheng X, Xia C (corresponding), Chen Z, Huang J, Gao F, Li G, Zhang B (corresponding), 2012
- 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/AKT pathway., Huang JG, Xia C (corresponding), Zheng XP, Yi TT, Wang XY, Song G, Zhang B (corresponding), 2011
- 12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis., Zhang B, Xia C (corresponding), 2010
- The expression of protein kinase B in gastric cancer cell apoptosis induced by 12-O-tetradecanoylphorbol-1, 3-acetate., Zhang B, Xia C (corresponding), 2009
- Roles of PLC-γ2 and PKCα in TPA-induced apoptosis of gastric cancer cells., Bing Zhang, Qiao Wu (corresponding), Xiao-Feng Ye, Su Liu, Xiao-Feng Lin, Mu-Chuan Chen, 2003
Awards
- 1999年: 甘肃省科技进步奖
- 2006年: 厦门大学《组织学与胚胎学》精品课程
- 2009年: 福建省《组织学与胚胎学》精品课程
- 2011年: 厦门大学首届“最受欢迎女教师”提名奖
- 2014年: 厦门市科技进步二等奖
