Areas of Focus
- 新型基因编辑工具的设计和开发
- RNA相关核酸酶机器的机制研究
Work Experience
- 2016-2018 博士后研究员 - 劳伦斯伯克利国家实验室 - 生物物理和生物成像中心
- 2018-2020 博士后研究员 - 加州大学伯克利分校 - 细胞分子生物学系
- 2020至今 助理教授、副教授 - 清华大学生命科学学院
- 2020至今 研究员 - 清华-北大生命科学联合中心、北京生物结构前沿研究中心
Academic Background & Achievements
- 2007-2011 学士：四川大学，生命科学学院
- 2011-2016 博士：清华大学，生命科学学院
- 在劳伦斯伯克利国家实验室和加州大学伯克利分校进行博士后研究
Publications
- Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ 等, 2024
- Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ 等, 2023
- Nucleases in gene-editing technologies: past and prologue, Liu JJ 等, 2023
- Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ 等, 2023
- The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ 等, 2023
- Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ 等, 2022
- Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ 等, 2021
- Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ 等, 2020
- Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ 等, 2019
- CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ 等, 2019
- Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ 等, 2019
- Structures of the CRISPR genome integration complex, Liu JJ 等, 2017
