Professor | 刘俊杰 | 数字化转型顾问

Name	刘俊杰
Contact Information	junjiegogoliu@tsinghua.edu.cn
Language ability	中文, 英语
Province	北京

Name

刘俊杰

Contact Information

junjiegogoliu@tsinghua.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	2007-2011 学士：四川大学，生命科学学院 2011-2016 博士：清华大学，生命科学学院在劳伦斯伯克利国家实验室和加州大学伯克利分校进行博士后研究
Work Experience	2016-2018 博士后研究员 - 劳伦斯伯克利国家实验室 - 生物物理和生物成像中心 2018-2020 博士后研究员 - 加州大学伯克利分校 - 细胞分子生物学系 2020至今助理教授、副教授 - 清华大学生命科学学院 2020至今研究员 - 清华-北大生命科学联合中心、北京生物结构前沿研究中心

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

Areas of Focus	新型基因编辑工具的设计和开发 RNA相关核酸酶机器的机制研究
Publications	Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ 等, 2024 Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ 等, 2023 Nucleases in gene-editing technologies: past and prologue, Liu JJ 等, 2023 Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ 等, 2023 The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ 等, 2023 Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ 等, 2022 Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ 等, 2021 Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ 等, 2020 Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ 等, 2019 CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ 等, 2019 Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ 等, 2019 Structures of the CRISPR genome integration complex, Liu JJ 等, 2017

Areas of Focus

新型基因编辑工具的设计和开发
RNA相关核酸酶机器的机制研究

Publications

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ 等, 2024
Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ 等, 2023
Nucleases in gene-editing technologies: past and prologue, Liu JJ 等, 2023
Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ 等, 2023
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ 等, 2023
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ 等, 2022
Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ 等, 2021
Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ 等, 2020
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ 等, 2019
CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ 等, 2019
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ 等, 2019
Structures of the CRISPR genome integration complex, Liu JJ 等, 2017

基因编辑 Crispr Cas系统核酸酶生物技术分子生物学基因组学生物工程 Rna机制酶研究

刘俊杰 - 清华大学

刘琦 - 同济大学

啜国晖 - 同济大学

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