Professor | 孙前文 | 数字化转型顾问

Name	孙前文
Contact Information	sunqianwen@mail.tsinghua.edu.cn
Language ability	英语, 汉语
Province	北京

Name

孙前文

Contact Information

sunqianwen@mail.tsinghua.edu.cn

Language ability

英语, 汉语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	2004-2009 博士：华中农业大学生科院 2000-2004 学士：华中农业大学生科院
Work Experience	2022-今副教授，清华大学生命科学学院 2014-2021 助理教授，清华大学生命科学学院 2014-今研究员，清华-北大生命科学联合中心 2009-2014 博士后，John Innes Centre, Norwich, UK

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

2004-2009 博士：华中农业大学生科院
2000-2004 学士：华中农业大学生科院

Work Experience

2022-今副教授，清华大学生命科学学院
2014-2021 助理教授，清华大学生命科学学院
2014-今研究员，清华-北大生命科学联合中心
2009-2014 博士后，John Innes Centre, Norwich, UK

Areas of Focus	各个层面的基因组调控事件，重点关注R-loop生物学研究与基因组调控
Publications	Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage, Weifeng Zhang, Zhuo Yang, Wenjie Wang, Qianwen Sun, 2024 DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis, Qin Li, Jincong Zhou, Shuai Li, Weifeng Zhang, Yingxue Du, Kuan Li, Yingxiang Wang, Qianwen Sun, 2023 DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis, Jincong Zhou, Xue Lei, Sarfraz Shafiq, Weifeng Zhang, Qin Li, Kuan Li, Jiafu Zhu, Zhicheng Dong, Xin-Jian He, Qianwen Sun, 2023 DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms, Wei Xu, Chao Liu, Zhe Zhang, Changbin Sun, Qin Li, Kuan Li, Hui Jiang, Wei Li, Qianwen Sun, 2023 R-loopAtlas: An integrated R-loop resource from 254 plant species sustained by a deep-learning-based tool, Kuan Li, Zhenzhen Wu, Jincong Zhou, Wei Xu, Ling Li, Chao Liu, Wei Li, Chengjun Zhang, Qianwen Sun, 2023 Intragenic tRNA-promoted R-loops orchestrate transcription interference for plant oxidative stress responses, Liu K, Sun Q, 2021 Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis, Cheng L, Wang W, Yao Y, Sun Q, 2021 RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts, Wang W, Li K, Yang Z, Hou Q, Zhao W W, Sun Q, 2021 RHON1 Co-transcriptionally Resolves R-Loops for Arabidopsis Chloroplast Genome Maintenance, Yang Z, Li M, Sun Q, 2020 The R-loop atlas of Arabidopsis development and responses to environmental stimuli, Xu W, Li K, Li S, Hou Q, Zhang Y, Liu K, Sun Q, 2020 Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation, Zhao S, Cheng L, Gao Y, Zhang B, Zheng X, Wang L, Li P, Sun Q, Li H, 2019 RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts, Yang Z, Hou Q, Cheng L, Xu W, Hong Y, Li S, Sun Q, 2017 The R-loop is a common chromatin feature of the Arabidopsis genome, Xu W, Xu H, Li K, Fan Y, Liu Y, Yang X, Sun Q, 2017 R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus, Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ, Dean C, 2013

Areas of Focus

各个层面的基因组调控事件，重点关注R-loop生物学研究与基因组调控

Publications

Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage, Weifeng Zhang, Zhuo Yang, Wenjie Wang, Qianwen Sun, 2024
DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis, Qin Li, Jincong Zhou, Shuai Li, Weifeng Zhang, Yingxue Du, Kuan Li, Yingxiang Wang, Qianwen Sun, 2023
DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis, Jincong Zhou, Xue Lei, Sarfraz Shafiq, Weifeng Zhang, Qin Li, Kuan Li, Jiafu Zhu, Zhicheng Dong, Xin-Jian He, Qianwen Sun, 2023
DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms, Wei Xu, Chao Liu, Zhe Zhang, Changbin Sun, Qin Li, Kuan Li, Hui Jiang, Wei Li, Qianwen Sun, 2023
R-loopAtlas: An integrated R-loop resource from 254 plant species sustained by a deep-learning-based tool, Kuan Li, Zhenzhen Wu, Jincong Zhou, Wei Xu, Ling Li, Chao Liu, Wei Li, Chengjun Zhang, Qianwen Sun, 2023
Intragenic tRNA-promoted R-loops orchestrate transcription interference for plant oxidative stress responses, Liu K, Sun Q, 2021
Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis, Cheng L, Wang W, Yao Y, Sun Q, 2021
RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts, Wang W, Li K, Yang Z, Hou Q, Zhao W W, Sun Q, 2021
RHON1 Co-transcriptionally Resolves R-Loops for Arabidopsis Chloroplast Genome Maintenance, Yang Z, Li M, Sun Q, 2020
The R-loop atlas of Arabidopsis development and responses to environmental stimuli, Xu W, Li K, Li S, Hou Q, Zhang Y, Liu K, Sun Q, 2020
Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation, Zhao S, Cheng L, Gao Y, Zhang B, Zheng X, Wang L, Li P, Sun Q, Li H, 2019
RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts, Yang Z, Hou Q, Cheng L, Xu W, Hong Y, Li S, Sun Q, 2017
The R-loop is a common chromatin feature of the Arabidopsis genome, Xu W, Xu H, Li K, Fan Y, Liu Y, Yang X, Sun Q, 2017
R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus, Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ, Dean C, 2013

基因组调控 R-Loop 生物学染色质结构转录调控基因组完整性分子机理拟南芥细菌酵母

孙前文 - 清华大学

Area of Focus
基因组 | 调控 | R-Loop | 生物学 | 转录 | Dna | Rna | 拟南芥 | 酵母 | 大肠杆菌

杨洪全 - 上海师范大学

王伟 - 北京大学

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