Professor | 陈春来 | 数字化转型顾问

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Name	陈春来
Contact Information	chunlai@tsinghua.edu.cn
Language ability	中文, 英语
Province	北京

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Name

陈春来

Contact Information

chunlai@tsinghua.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	1999-2003 学士：北京大学化学与分子工程学院 2003-2008 博士：北京大学化学与分子工程学院
Work Experience	2008-2015 - 宾夕法尼亚大学 - 博士后 2015-2018 - 清华大学生命科学学院 - 助理教授 2018-至今 - 清华大学生命科学学院 - 副教授

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

1999-2003 学士：北京大学化学与分子工程学院
2003-2008 博士：北京大学化学与分子工程学院

Work Experience

2008-2015 - 宾夕法尼亚大学 - 博士后
2015-2018 - 清华大学生命科学学院 - 助理教授
2018-至今 - 清华大学生命科学学院 - 副教授

Areas of Focus	发展新型单分子荧光技术蛋白在DNA上的靶向搜寻机制的研究 CRISPR系列蛋白靶向和剪切机制的研究
Publications	General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Yuan Zhang, Chen Yang, Sijia Peng, Jing Ling, Peng Chen, Yumiao Ma, Wenjuan Wang, Zhixing Chen, Chunlai Chen, 2023 Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage, Ruirui Sun, Yuqian Zhao, Wenjuan Wang, Jun-Jie Gogo Liu, Chunlai Chen, 2023 Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch, Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen, Xianyang Fang, 2023 Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W Hildebrand, Chunlai Chen, Brian K. Kobilka, 2023 Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination, Jingfei Xu, Lingyun Zhao, Sijia Peng, Huiying Chu, Rui Liang, Meng Tian, Philip P. Connell, Guohui Li, Chunlai Chen, Hong-Wei Wang, 2021 Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Xiaolin Niu, Ruirui Sun, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen, Xianyang Fang, 2021 Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Mengyi Yang, Ruirui Sun, Pujuan Deng, Yuzhuo Yang, Wenjuan Wang, Jun-Jie Gogo Liu, Chunlai Chen, 2021 Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction, Ming-Jie Han, Qing-tao He, Mengyi Yang, Chao Chen, Yirong Yao, Xiaohong Liu, Yuchuan Wang, Zhong-liang Zhu, Kong-kai Zhu, Changxiu Qu, Fan Yang, Cheng Hu, Xuzhen Guo, Dawei Zhang, Chunlai Chen, Jin-peng Sun, Jiangyun Wang, 2021 Phase separation at the nanoscale quantified by dcFCCS, Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, Chunlai Chen, 2020 Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, Sijia Peng, Xiaowei Wang, Lu Zhang, Shanshan He, Xin Sheng Zhao, Xuhui Huang, Chunlai Chen, 2020

Areas of Focus

发展新型单分子荧光技术
蛋白在DNA上的靶向搜寻机制的研究
CRISPR系列蛋白靶向和剪切机制的研究

Publications

General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Yuan Zhang, Chen Yang, Sijia Peng, Jing Ling, Peng Chen, Yumiao Ma, Wenjuan Wang, Zhixing Chen, Chunlai Chen, 2023
Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage, Ruirui Sun, Yuqian Zhao, Wenjuan Wang, Jun-Jie Gogo Liu, Chunlai Chen, 2023
Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch, Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen, Xianyang Fang, 2023
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W Hildebrand, Chunlai Chen, Brian K. Kobilka, 2023
Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination, Jingfei Xu, Lingyun Zhao, Sijia Peng, Huiying Chu, Rui Liang, Meng Tian, Philip P. Connell, Guohui Li, Chunlai Chen, Hong-Wei Wang, 2021
Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Xiaolin Niu, Ruirui Sun, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen, Xianyang Fang, 2021
Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Mengyi Yang, Ruirui Sun, Pujuan Deng, Yuzhuo Yang, Wenjuan Wang, Jun-Jie Gogo Liu, Chunlai Chen, 2021
Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction, Ming-Jie Han, Qing-tao He, Mengyi Yang, Chao Chen, Yirong Yao, Xiaohong Liu, Yuchuan Wang, Zhong-liang Zhu, Kong-kai Zhu, Changxiu Qu, Fan Yang, Cheng Hu, Xuzhen Guo, Dawei Zhang, Chunlai Chen, Jin-peng Sun, Jiangyun Wang, 2021
Phase separation at the nanoscale quantified by dcFCCS, Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, Chunlai Chen, 2020
Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, Sijia Peng, Xiaowei Wang, Lu Zhang, Shanshan He, Xin Sheng Zhao, Xuhui Huang, Chunlai Chen, 2020

荧光单分子技术蛋白 Dna 靶向机制 Crispr 剪切研究

张中林 - 上海师范大学

Area of Focus
Della | 蛋白 | 复合体 | 解离 | 功能 | 赤霉素 | 调控 | 植物 | 生长 | 发育 | 分子 | 机理 | 激素 | 信号 | 通路 | 基因组 | 编辑 | 技术 | 应用 | Crispr | 基因 | 修改 | 生物技术 | 农业 | 研究

陈春来 - 清华大学

Area of Focus
荧光 | 单分子 | 技术 | 蛋白 | Dna | 靶向 | 机制 | Crispr | 剪切 | 研究

伊成器 - 北京大学

Area of Focus
Rna | 修饰 | 表观转录组学 | 基因 | 编辑 | Dna | 表观基因组学 | 测序 | 转录组 | 甲基化 | Crispr | 技术 | 精确 | 农业 | 生物医药 | 工具 | 发展 | 创新 | 单细胞 | 生物标志物 | 疾病 | 染色质 | 可及性

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