Professor | 李丕龙 | 数字化转型顾问

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Name	李丕龙
Contact Information	pilongli@mail.tsinghua.edu.cn
Language ability	英语, 汉语
Province	北京

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Name

李丕龙

Contact Information

pilongli@mail.tsinghua.edu.cn

Language ability

英语, 汉语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	1996-2000 学士：北京大学 2000-2002 硕士：香港科技大学 2002-2009 博士：德克萨斯大学西南医学中心博士后研究：德克萨斯大学西南医学中心，宾夕法尼亚大学
Work Experience	2016-至今：清华大学生命科学学院 - 助理教授、副教授
Awards	中国生物物理学会生物大分子相分离与相变分会副理事长 Molecular Cell杂志编委会成员 Biochemical Journal杂志副编辑 Cell，Nature，Science等杂志的审稿人

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

1996-2000 学士：北京大学
2000-2002 硕士：香港科技大学
2002-2009 博士：德克萨斯大学西南医学中心
博士后研究：德克萨斯大学西南医学中心，宾夕法尼亚大学

Work Experience

2016-至今：清华大学生命科学学院 - 助理教授、副教授

Awards

中国生物物理学会生物大分子相分离与相变分会副理事长
Molecular Cell杂志编委会成员
Biochemical Journal杂志副编辑
Cell，Nature，Science等杂志的审稿人

Areas of Focus	相分离现象的普适化调控机制与规律相分离在自噬、转录调控、表观遗传等领域的生物学意义基于相分离的技术开发与应用
Publications	Dual-Role Transcription Factors Stabilize Intermediate Expression Levels, He J, Huo X, Pei G, Jia Z, Yan Y, Yu J, Qu H, Xie Y, Yuan J, Zheng Y, Hu Y, Shi M, You K, Li T, Ma T, Zhang M Q, Ding S, Li P, Li Y, 2024 An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies, Jia W, Li W, Li Z, Li P, 2024 Prevalent aberrant condensates of onco-fusion transcription factors and their dissolution as potential cancer therapy, Wang Y, Yu C, Pei G, Jia W, Li T, Li P, 2023 Programming cell-surface signaling by phase-separation-controlled compartmentalization, Li R, Li T, Lu G, Cao Z, Chen B, Wang Y, Du J, Li P, 2022 Histone H2B.8 compacts flowering plant sperm through chromatin phase separation, Buttress T, He S, Wang L, Zhou S, Saalbach G, Vickers M, Li G, Li P, Feng X, 2022 Screening membraneless organelle participants with machine-learning models that integrate multimodal features, Chen Z, Hou C, Wang L, Yu C, Chen T, Shen B, Hou Y, Li P, Li T, 2022 Myosin 1D and the branched actin network control the condensation of p62 bodies, Feng X, Du W, Ding M, Zhao W, Xirefu X, Ma M, Zhuang Y, Fu X, Shen J, Zhang J, Lei X, Sun D, Xi Q, Aisa Y, Chen Q, Li Y, Wang W, Huang S, Yu L, Li P, Mi N, 2022 Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome, Xu W, Pei G, Liu H, Ju X, Wang J, Ding Q, Li P, 2021 Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes, Fang X, Wang L, Ishikawa R, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C, 2019 Phase transitions in the assembly of multivalent signalling proteins, Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK, 2012

Areas of Focus

相分离现象的普适化调控机制与规律
相分离在自噬、转录调控、表观遗传等领域的生物学意义
基于相分离的技术开发与应用

Publications

Dual-Role Transcription Factors Stabilize Intermediate Expression Levels, He J, Huo X, Pei G, Jia Z, Yan Y, Yu J, Qu H, Xie Y, Yuan J, Zheng Y, Hu Y, Shi M, You K, Li T, Ma T, Zhang M Q, Ding S, Li P*, Li Y*, 2024
An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies, Jia W, Li W, Li Z*, Li P*, 2024
Prevalent aberrant condensates of onco-fusion transcription factors and their dissolution as potential cancer therapy, Wang Y, Yu C, Pei G, Jia W, Li T*, Li P*, 2023
Programming cell-surface signaling by phase-separation-controlled compartmentalization, Li R, Li T, Lu G, Cao Z, Chen B, Wang Y, Du J*, Li P*, 2022
Histone H2B.8 compacts flowering plant sperm through chromatin phase separation, Buttress T, He S, Wang L, Zhou S, Saalbach G, Vickers M, Li G, Li P*, Feng X*, 2022
Screening membraneless organelle participants with machine-learning models that integrate multimodal features, Chen Z, Hou C, Wang L, Yu C, Chen T, Shen B, Hou Y, Li P*, Li T*, 2022
Myosin 1D and the branched actin network control the condensation of p62 bodies, Feng X, Du W, Ding M, Zhao W, Xirefu X, Ma M, Zhuang Y, Fu X, Shen J, Zhang J, Lei X, Sun D, Xi Q, Aisa Y, Chen Q, Li Y, Wang W, Huang S, Yu L, Li P*, Mi N*, 2022
Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome, Xu W, Pei G, Liu H, Ju X, Wang J, Ding Q, Li P*, 2021
Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes, Fang X, Wang L, Ishikawa R, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P*, Dean C*, 2019
Phase transitions in the assembly of multivalent signalling proteins, Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK*, 2012

相分离调控机制普适规律自噬转录调控表观遗传技术开发生物学意义应用生物分子

刘晨光 - 上海交通大学

李丕龙 - 清华大学

龙艳萍 - 南方科技大学

Area of Focus
单细胞 | 测序 | 植物生物学 | 基因组学 | 转录组学 | 技术开发 | 基因调控 | 分子生物学 | 生物信息学 | 数据分析 | 长读取 | 第三代 | 应用 | 创新 | 基因表达 | 调控 | 研究 | 植物 | 机制

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