Professor | 王菲菲 | 数字化转型顾问

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Name	王菲菲
Contact Information	ffwang@fudan.edu.cn
Language ability	中文, 英文
Province	上海

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Name

王菲菲

Contact Information

ffwang@fudan.edu.cn

Language ability

中文, 英文

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	1999.09—2003.06 本科：复旦大学，生命科学学院 2005.09—2010.07 博士：复旦大学，基础医学院，药理学
Work Experience	2017.12—至今 - 复旦大学基础医学院 - 教授 2012.12—2017.12 - 复旦大学基础医学院 - 副教授 2008.07—2012.12 - 复旦大学基础医学院 - 讲师 2014.04—2015.10 - 美国威斯康星大学麦迪逊分校 - 博士后
Awards	2011: 教育部自然科学一等奖，阿片受体信号转导新机制（第四完成人） 2013: 教育部自然科学二等奖，神经可塑性调节新机制的研究（第三完成人）

University/Lab Affiliation and Title

复旦大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

1999.09—2003.06 本科：复旦大学，生命科学学院
2005.09—2010.07 博士：复旦大学，基础医学院，药理学

Work Experience

2017.12—至今 - 复旦大学基础医学院 - 教授
2012.12—2017.12 - 复旦大学基础医学院 - 副教授
2008.07—2012.12 - 复旦大学基础医学院 - 讲师
2014.04—2015.10 - 美国威斯康星大学麦迪逊分校 - 博士后

Awards

2011: 教育部自然科学一等奖，阿片受体信号转导新机制（第四完成人）
2013: 教育部自然科学二等奖，神经可塑性调节新机制的研究（第三完成人）

Areas of Focus	奖赏与应激的神经可塑性机制：脑内基因的表达和功能，对神经元正常生理功能至关重要。基因表达和功能的异常是神经系统疾病发生发展的病理基础。课题组研究以脑内神经信号网络及基因表达调控为切入点，着重解析了成瘾药物，应激刺激等对相关脑区神经环路重塑的细胞和分子基础，为干预病理性记忆以及情绪障碍相关的脑疾病提供潜在生物学靶点。
Publications	CRHCeA→VTA inputs inhibit the positive ensembles to induce negative affect of opiate withdrawal, Jiang C#, Yang X#, He G#, Wang F, Xu W, Mao Y, and Ma L, Wang F, 2021 O-GlcNAcylation in ventral tegmental area dopaminergic neurons regulates the response to natural reward and motor learning ability, Shao M#, Yang X#, Zhang C, Jiang C, Ma L, Wang F, 2021 Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward, Jiang C, Wang X, Le Q, Liu P, Liu C, Wang Z, He G, Zheng P, Wang F, Ma L, 2021 Dorsal hippocampus- and ACC-projecting medial septum neurons differentially contribute to the recollection of episodic-like memory, Jin T, Chen R, Shao M, Yang X, Ma L, Wang F, 2020 Retrieval-driven hippocampal Nptx2 Plasticity Facilitates the Extinction of Cocaine-Associated Context Memory, Wang Z#, Jin T#, Le Q#, Liu C, Wang X, Wang F, Ma L, 2020 Retrieval-induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation, Liu C, Sun X, Wang Z, Le Q, Liu P, Jiang C, Wang F, Ma L, 2018 GRK5 regulates social behaviour via suppression of mTORC1 signaling in medial prefrontal cortex, Niu B#, Liu P#, Shen M#, Liu C, Wang L, Wang F and Ma L, 2018 Integrative Single-Cell Transcriptomics Reveals Molecular Networks Defining Neuronal Maturation during Adult Neurogenesis, Gao Y#, Wang F#, Brian E. Eisinger#, Laurel E. Kelnhofer1, Emily Jobe and Zhao X, 2017 Mesolimbic leptin signaling negatively regulates cocaine conditioned reward, Shen M, Jiang C, Liu P, Wang F, Ma L, 2016 Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis, Wang F, Tidei J, Polich E, Gao Y, Zhao H, Perrone-Bizzozero N, Guo W, Zhao X*, 2015

Areas of Focus

奖赏与应激的神经可塑性机制：脑内基因的表达和功能，对神经元正常生理功能至关重要。基因表达和功能的异常是神经系统疾病发生发展的病理基础。课题组研究以脑内神经信号网络及基因表达调控为切入点，着重解析了成瘾药物，应激刺激等对相关脑区神经环路重塑的细胞和分子基础，为干预病理性记忆以及情绪障碍相关的脑疾病提供潜在生物学靶点。

Publications

CRHCeA→VTA inputs inhibit the positive ensembles to induce negative affect of opiate withdrawal, Jiang C#, Yang X#, He G#, Wang F, Xu W, Mao Y, and Ma L*, Wang F*, 2021
O-GlcNAcylation in ventral tegmental area dopaminergic neurons regulates the response to natural reward and motor learning ability, Shao M#, Yang X#, Zhang C, Jiang C, Ma L*, Wang F*, 2021
Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward, Jiang C, Wang X, Le Q, Liu P, Liu C, Wang Z, He G, Zheng P, Wang F*, Ma L*, 2021
Dorsal hippocampus- and ACC-projecting medial septum neurons differentially contribute to the recollection of episodic-like memory, Jin T, Chen R, Shao M, Yang X, Ma L, Wang F*, 2020
Retrieval-driven hippocampal Nptx2 Plasticity Facilitates the Extinction of Cocaine-Associated Context Memory, Wang Z#, Jin T#, Le Q#, Liu C, Wang X, Wang F*, Ma L*, 2020
Retrieval-induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation, Liu C, Sun X, Wang Z, Le Q, Liu P, Jiang C, Wang F*, Ma L*, 2018
GRK5 regulates social behaviour via suppression of mTORC1 signaling in medial prefrontal cortex, Niu B#, Liu P#, Shen M#, Liu C, Wang L, Wang F* and Ma L*, 2018
Integrative Single-Cell Transcriptomics Reveals Molecular Networks Defining Neuronal Maturation during Adult Neurogenesis, Gao Y#, Wang F#, Brian E. Eisinger#, Laurel E. Kelnhofer1, Emily Jobe and Zhao X*, 2017
Mesolimbic leptin signaling negatively regulates cocaine conditioned reward, Shen M, Jiang C, Liu P, Wang F*, Ma L*, 2016
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis, Wang F, Tidei J, Polich E, Gao Y, Zhao H, Perrone-Bizzozero N*, Guo W*, Zhao X*, 2015

神经可塑性奖赏应激基因表达神经环路成瘾药物应激刺激病理性记忆情绪障碍脑疾病

徐成丽 - 北京协和医学院

孙向东 - 南方医科大学

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