通过数据科学改进蛋白质纯化：Alexion Pharmaceuticals 案例研究
技术
- 分析与建模 - 大数据分析
- 平台即服务 (PaaS) - 应用开发平台
适用行业
- 设备与机械
- 药品
适用功能
- 产品研发
用例
- 时间敏感网络
服务
- 数据科学服务
- 系统集成
关于客户
Alexion Pharmaceuticals, Inc. 是一家生物制药公司，致力于通过开发和商业化改变生命的疗法，为患有毁灭性罕见疾病的患者提供服务。该公司的产品重点包括补体级联中的新分子和靶点的研究以及血液学、肾病学、神经病学、代谢学和心脏病学等核心治疗领域的开发工作。 Alexion 利用生物疗法解决罕见疾病，改变了许多遭受全身性重症肌无力 (gMG) 和低磷酸酯酶症 (HPP) 等毁灭性疾病影响的患者的生活。
挑战
Alexion Pharmaceuticals 是一家生物制药公司，其下游工艺开发业务面临着多项挑战。该公司一直在与数据孤岛作斗争，因为仪器供应商没有相互集成，导致手动数据移动。供应商专有的数据格式需要他们特定的工具，这阻碍了第三方数据标准化。此外，信息学主管必须从多个位置手动移动、更新和整理文件。科学家们还被要求将峰信息输入到分析软件中。此外，现有的仪表板工具具有陡峭的学习曲线并且无法管理元数据。科学家们不断需要测试他们的假设并从异构数据源中获得有用的见解。
解决方案
Alexion Pharmaceuticals 采用 Tetra 数据平台 (TDP) 来克服这些挑战。 TDP 传输、标准化和协调云中的孤立数据。新数据通过 ElasticSearch 建立索引并构建到 SQL 表中以支持搜索和查询。 TetraScience 的管道对下游可视化、存储或 AI/ML 见解的数据进行标准化和结构化。数据从源流到云端，再到 ELN 和数据科学目标，无需任何手动干预。 TetraScience API 可用于将统一数据导入数据科学应用程序。在 Streamlit 等可定制的数据科学应用程序中使用这些数据使科学家能够完全控制色谱图叠加和集成。
运营影响
数量效益
Case Study missing?
Start adding your own!
Register with your work email and create a new case study profile for your business.
相关案例.
Case Study
Case Study: Pfizer
Pfizer’s high-performance computing software and systems for worldwide research and development support large-scale data analysis, research projects, clinical analytics, and modeling. Pfizer’s computing services are used across the spectrum of research and development efforts, from the deep biological understanding of disease to the design of safe, efficacious therapeutic agents.
Case Study
Smart Water Filtration Systems
Before working with Ayla Networks, Ozner was already using cloud connectivity to identify and solve water-filtration system malfunctions as well as to monitor filter cartridges for replacements.But, in June 2015, Ozner executives talked with Ayla about how the company might further improve its water systems with IoT technology. They liked what they heard from Ayla, but the executives needed to be sure that Ayla’s Agile IoT Platform provided the security and reliability Ozner required.
Case Study
IoT enabled Fleet Management with MindSphere
In view of growing competition, Gämmerler had a strong need to remain competitive via process optimization, reliability and gentle handling of printed products, even at highest press speeds. In addition, a digitalization initiative also included developing a key differentiation via data-driven services offers.
Case Study
Predictive Maintenance for Industrial Chillers
For global leaders in the industrial chiller manufacturing, reliability of the entire production process is of the utmost importance. Chillers are refrigeration systems that produce ice water to provide cooling for a process or industrial application. One of those leaders sought a way to respond to asset performance issues, even before they occur. The intelligence to guarantee maximum reliability of cooling devices is embedded (pre-alarming). A pre-alarming phase means that the cooling device still works, but symptoms may appear, telling manufacturers that a failure is likely to occur in the near future. Chillers who are not internet connected at that moment, provide little insight in this pre-alarming phase.
Case Study
Premium Appliance Producer Innovates with Internet of Everything
Sub-Zero faced the largest product launch in the company’s history:It wanted to launch 60 new products as scheduled while simultaneously opening a new “greenfield” production facility, yet still adhering to stringent quality requirements and manage issues from new supply-chain partners. A the same time, it wanted to increase staff productivity time and collaboration while reducing travel and costs.
Case Study
Integration of PLC with IoT for Bosch Rexroth
The application arises from the need to monitor and anticipate the problems of one or more machines managed by a PLC. These problems, often resulting from the accumulation over time of small discrepancies, require, when they occur, ex post technical operations maintenance.
