Areas of Focus
- 定向进化
- 蛋白质工程
- 高通量筛选
- 天然及非天然化合物的生物全合成
Work Experience
- 2019-09~现在 - 中国科学院深圳先进技术研究院 - 研究员
- 2016-09~2019-09 - 斯克里普斯研究所 - 博士后
- 2016-09~2019-09 - 加州大学伯克利分校 - 博士后
Academic Background & Achievements
- 2010-08--2016-05 博士: 斯克里普斯研究所
- 2006-08--2010-05 学士: 南洋理工大学
Publications
- Elucidation of genes enhancing natural product biosynthesis through co - evolution analysis, 通讯作者, 2024
- Co-evolved genes improve the biosynthesis of secondary metabolites, 第 2 作者, 2024
- Engineering yeast for the de novo synthesis of jasmonates, 通讯作者, 2024
- Pathway Evolution Through a Bottlenecking ‐ Debottlenecking Strategy and Machine Learning ‐Aided Flux Balancing, 通讯作者, 2024
- UniKP: a unified framework for the prediction of enzyme kinetic parameters, 通讯作者, 2023
- One-pot selective biosynthesis of Tyrian purple in Escherichia coli, 通讯作者, 2023
- Dynamic upregulation of the rate -limiting enzyme for valerolactam biosynthesis in Corynebacterium glutamicum, 通讯作者, 2023
- Systematic genetic modifications of cell wall biosynthesis enhanced the secretion and surface -display of polysaccharide degrading enzymes in Saccharomyces cerevisiae, 通讯作者, 2023
- Development of an efficient yeast platform for cannabigerolic acid biosynthesis, 通讯作者, 2023
- IPPF-FE: an integrated peptide and protein function prediction framework based on fused features and ensemble models, 通讯作者, 2023
- Creation of a Yeast Strain with Co - Translationally Acylated Nucleosomes, 通讯作者, 2022
- Harnessing nature's biosynthetic capacity to facilitate total synthesis, 通讯作者, 2022
- 面向合成生物学的机器学习方法及应用, 第 6 作者, 2021
- 代谢工程改造酿酒酵母底盘细胞, 第 5 作者, 2021
- Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols, 第 10 作者, 2021
- Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae, 通讯作者, 2020
- Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae, 第 7 作者, 2020
- Complete biosynthesis of cannabinoids and their unnatural analogues in yeast, 第 1 作者, 2019
- Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria, 第 1 作者, 2017
- Recombinant thiopeptides containing noncanonical amino acids, 第 1 作者, 2016
- Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator, 第 1 作者, 2016