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张刚
Life Science
中国科学院大学
北京
Language: 中文, 英语
病原菌
耐药性
噬菌体防御
机制
微生物学
抗生素
Crispr
基因组岛
整合酶
基因转移
Areas of Focus
- 病原菌耐药与噬菌体防御机制
Work Experience
- 2018-10~现在 - 中国科学院微生物研究所 - 副研究员
- 2011-07~2018-10 - 中国科学院微生物研究所 - 助理研究员
Academic Background & Achievements
- 2008-09--2011-06 博士: 中国农业大学
- 2005-09--2008-06 硕士: 石河子大学
- 2001-09--2005-06 学士: 石河子大学
Publications
- Harnessing the Native Type I-F CRISPR-Cas System of Acinetobacter baumannii for Genome Editing and Gene Repression, 第11作者, 2023
- Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands, 第1作者, 2023
- IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics (vol 13, e03340-21, 2022), 第4作者, 2022
- In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment, 第6作者, 2022
- An urban soil environmental E. coli ST354 isolate co-harbouring mcr-1 and bla NDM-9, 第4作者, 2022
- Amplification of bla(NDM-1) mediated by ISCR1 confers hyperresistance to carbapenem, 第4作者, 2022
- The integrase of genomic island GIsul2 mediates the mobilization of GIsul2 and ISCR-related element CR2-sul2 unit through site-specific recombination, 第1作者, 2022
- IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics, 第4作者, 2022
- Efficient Suppression of Natural Plasmid-Borne Gene Expression in Carbapenem-Resistant Klebsiella pneumoniae Using a Compact CRISPR Interference System, 第11作者, 2022
- Streptococcus sputorum , a Novel Member of Streptococcus with Multidrug Resistance, Exhibits Cytotoxicity, 第6作者, 2021
- The Shared Resistome of Human and Pig Microbiota Is Mobilized by Distinct Genetic Elements, 第4作者, 2021
- Systematic analysis of supervised machine learning as an effective approach to predicate beta-lactam resistance phenotype in Streptococcus pneumoniae, 第5作者, 2020
- A new intrinsic aminoglycoside 6 '-N-acetyltransferase subclass, AAC(6 ')-III, in Burkholderia pseudomallei, Burkholderia mallei and Burkholderia oklahomensis, 第1作者, 2020
- Co-existence of the carbapenem resistance genes blaKPC-2 and blaNDM-1 in a Raoultella planticola isolate in China, 第7作者, 2020
- A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol, 第1作者, 2019
- Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm, 第6作者, 2019
- 细菌中基因组岛的转移与调控机制研究进展, Regulation, excision and horizontal transfer of genomic islands in bacteria, 第2作者, 2018
- Five novel carbapenem-hydrolysing OXA-type beta-lactamase groups are intrinsic in Acinetobacter spp., 第2作者, 2018
- A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3\, 2017
- Iscr2 is associated with the dissemination of multiple resistance genes among vibrio spp. and pseudoalteromonas spp. isolated from farmed fish, 第3作者, 2017
- 细菌固有耐药的研究进展, The intrinsic resistance of bacteria, 第1作者, 2016
- Identification of Novel Cryptic Aminoglycoside Phosphotransferases in Pseudomonas aeruginosa, 第1作者, 2016
- Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae, 第1作者, 2015
- Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group, 第4作者
