Professor | 张小康 | 数字化转型顾问

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Name	张小康
Contact Information	xk.zhang@siat.ac.cn
Language ability	中文, 英语
Province	广东

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Name

张小康

Contact Information

xk.zhang@siat.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2001-09--2005-07 学士学位: 中山大学 2005-09--2009-03 硕士学位: 中山大学 2009-09--2012-07 博士学位: 中国科学技术大学
Work Experience	2021-01~现在 - 中国科学院深圳先进技术研究院 - 教授 2020-04~2021-01 - 中国科学院深圳先进技术研究院 - 课题组长 2016-01~2020-04 - 浙江大学 - 副教授 2013-10~2016-01 - 巴斯德研究所（巴黎） - 博士后 2012-10~2013-06 - 欧洲分子生物学实验室 - 博士后

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2001-09--2005-07 学士学位: 中山大学
2005-09--2009-03 硕士学位: 中山大学
2009-09--2012-07 博士学位: 中国科学技术大学

Work Experience

2021-01~现在 - 中国科学院深圳先进技术研究院 - 教授
2020-04~2021-01 - 中国科学院深圳先进技术研究院 - 课题组长
2016-01~2020-04 - 浙江大学 - 副教授
2013-10~2016-01 - 巴斯德研究所（巴黎） - 博士后
2012-10~2013-06 - 欧洲分子生物学实验室 - 博士后

Areas of Focus	原位研究蛋白构象动态及其与配体和天然磷脂的相互作用冷冻电镜技术
Publications	ALMT1介导的拟南芥铝抗性结构基础, Wang, Jiangqin, Yu, Xiafei, Ding, Zhong Jie, Zhang, Xiaokang, Luo, Yanping, Xu, Ximing, Xie, Yuan, Li, Xiaoxiao, Yuan, Tian, Zheng, Shao Jian, Yang, Wei, Guo, Jiangtao, 2021 黄病毒颗粒上的表位排列有助于Mab C10在寨卡和登革热病毒中的非凡中和广度, Sharma, Arvind, Zhang, Xiaokang, Dejnirattisai, Wanwisa, Dai, Xinghong, Gong, Danyang, Wongwiwat, Wiyada, Duquerroy, Stephane, Rouvinski, Alexander, Vaney, MarieChristine, GuardadoCalvo, Pablo, Haouz, Ahmed, England, Patrick, Sun, Ren, Zhou, Z Hong, Mongkolsapaya, Juthathip, Screaton, Gavin R, Rey, Felix A, 2021 人类TRPM2通道中选择性过滤器作为门的结构和功能基础, Yu, Xiafe, Xie, Yuan, Zhang, Xiaokang, Ma, Cheng, Liu, Likun, Zhen, Wenxuan, Xu, Lingyi, Zhang, Jianmin, Liang, Yan, Zhao, Lixia, Gao, Xiuxia, Yu, Peilin, Luo, Jianhong, Jiang, LinHua, Nie, Yan, Yang, Fan, Guo, Jiangtao, Yang, Wei, 2021 人类V2加压素受体配体识别和激活的分子基础, Fulai Zhou, Chenyu Ye, Xiaomin Ma, Wanchao Yin, Tristan ICroll, Qingtong Zhou, Xinheng He, Xiaokang Zhang, Dehua Yang, Peiyi Wang, HEric Xu, MingWei Wang, Yi Jiang, 2021 海马抑制性突触中GABA(A)受体的中相组织, Liu, YunTao, Tao, ChangLu, Zhang, Xiaokang, Xia, Wenjun, Shi, DongQing, Qi, Lei, Xu, Cheng, Sun, Rong, Li, XiaoWei, Lau, PakMing, Zhou, Z Hong, Bi, GuoQiang, 2020 人类单羧酸转运蛋白2的协同运输机制, Zhang, Bo, Jin, Qiuheng, Xu, Lizhen, Li, Ningning, Meng, Ying, Chang, Shenghai, Zheng, Xiang, Wang, Jiangqin, Chen, Yuan, Neculai, Dante, Gao, Ning, Zhang, Xiaokang, Yang, Fan, Guo, Jiangtao, Ye, Sheng, 2020 人类Pannexin 1通道的冷冻电镜结构, Jin, Qiuheng, Zhang, Bo, Zheng, Xiang, Li, Ningning, Xu, Lingyi, Xie, Yuan, Song, Fangjun, Bhat, Eijaz Ahmed, Chen, Yuan, Gao, Ning, Guo, Jiangtao, Zhang, Xiaokang, Ye, Sheng, 2020 Begomovirus双生病毒颗粒的冷冻电镜结构, Xu, Xiongbiao, Zhang, Qing, Hong, Jian, Li, Zhenghe, Zhang, Xiaokang, Zhou, Xueping, 2019 人类α5β3 GABAA受体的冷冻电镜结构, Liu Si, Xu Lingyi, Guan Fenghui, Liu Yuntao, Cui Yanxiang, Zhang Qing, Zheng Xiang, Bi Guoqiang, Zhou Hong Z, Zhang Xiaokang, Ye Sheng, 2018 成熟登革热病毒的3.5-Å分辨率冷冻电镜结构, Xiaokang Zhang, Peng Ge, Xuekui Yu, Jennifer M Brannan, Guoqiang Bi, Qinfen Zhang, Stan Schein, Z Hong Zhou, 2013 低成本高性能GPU计算解决方案用于原子分辨率冷冻电镜单颗粒重建, Zhang, Xiaokang, Zhang, Xing, Zhou, Z Hong, 2010

Areas of Focus

原位研究蛋白构象动态及其与配体和天然磷脂的相互作用
冷冻电镜技术

Publications

ALMT1介导的拟南芥铝抗性结构基础, Wang, Jiangqin, Yu, Xiafei, Ding, Zhong Jie, Zhang, Xiaokang, Luo, Yanping, Xu, Ximing, Xie, Yuan, Li, Xiaoxiao, Yuan, Tian, Zheng, Shao Jian, Yang, Wei, Guo, Jiangtao, 2021
黄病毒颗粒上的表位排列有助于Mab C10在寨卡和登革热病毒中的非凡中和广度, Sharma, Arvind, Zhang, Xiaokang, Dejnirattisai, Wanwisa, Dai, Xinghong, Gong, Danyang, Wongwiwat, Wiyada, Duquerroy, Stephane, Rouvinski, Alexander, Vaney, MarieChristine, GuardadoCalvo, Pablo, Haouz, Ahmed, England, Patrick, Sun, Ren, Zhou, Z Hong, Mongkolsapaya, Juthathip, Screaton, Gavin R, Rey, Felix A, 2021
人类TRPM2通道中选择性过滤器作为门的结构和功能基础, Yu, Xiafe, Xie, Yuan, Zhang, Xiaokang, Ma, Cheng, Liu, Likun, Zhen, Wenxuan, Xu, Lingyi, Zhang, Jianmin, Liang, Yan, Zhao, Lixia, Gao, Xiuxia, Yu, Peilin, Luo, Jianhong, Jiang, LinHua, Nie, Yan, Yang, Fan, Guo, Jiangtao, Yang, Wei, 2021
人类V2加压素受体配体识别和激活的分子基础, Fulai Zhou, Chenyu Ye, Xiaomin Ma, Wanchao Yin, Tristan ICroll, Qingtong Zhou, Xinheng He, Xiaokang Zhang, Dehua Yang, Peiyi Wang, HEric Xu, MingWei Wang, Yi Jiang, 2021
海马抑制性突触中GABA(A)受体的中相组织, Liu, YunTao, Tao, ChangLu, Zhang, Xiaokang, Xia, Wenjun, Shi, DongQing, Qi, Lei, Xu, Cheng, Sun, Rong, Li, XiaoWei, Lau, PakMing, Zhou, Z Hong, Bi, GuoQiang, 2020
人类单羧酸转运蛋白2的协同运输机制, Zhang, Bo, Jin, Qiuheng, Xu, Lizhen, Li, Ningning, Meng, Ying, Chang, Shenghai, Zheng, Xiang, Wang, Jiangqin, Chen, Yuan, Neculai, Dante, Gao, Ning, Zhang, Xiaokang, Yang, Fan, Guo, Jiangtao, Ye, Sheng, 2020
人类Pannexin 1通道的冷冻电镜结构, Jin, Qiuheng, Zhang, Bo, Zheng, Xiang, Li, Ningning, Xu, Lingyi, Xie, Yuan, Song, Fangjun, Bhat, Eijaz Ahmed, Chen, Yuan, Gao, Ning, Guo, Jiangtao, Zhang, Xiaokang, Ye, Sheng, 2020
Begomovirus双生病毒颗粒的冷冻电镜结构, Xu, Xiongbiao, Zhang, Qing, Hong, Jian, Li, Zhenghe, Zhang, Xiaokang, Zhou, Xueping, 2019
人类α5β3 GABAA受体的冷冻电镜结构, Liu Si, Xu Lingyi, Guan Fenghui, Liu Yuntao, Cui Yanxiang, Zhang Qing, Zheng Xiang, Bi Guoqiang, Zhou Hong Z, Zhang Xiaokang, Ye Sheng, 2018
成熟登革热病毒的3.5-Å分辨率冷冻电镜结构, Xiaokang Zhang, Peng Ge, Xuekui Yu, Jennifer M Brannan, Guoqiang Bi, Qinfen Zhang, Stan Schein, Z Hong Zhou, 2013
低成本高性能GPU计算解决方案用于原子分辨率冷冻电镜单颗粒重建, Zhang, Xiaokang, Zhang, Xing, Zhou, Z Hong, 2010

蛋白质构象动态配体磷脂生物物理学膜蛋白结构功能冷冻电镜突触蛋白

宋高洁 - 华东师范大学

闫创业 - 清华大学

王佳伟 - 清华大学

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