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张海平
Life Sciences
中国科学院大学
广东
Language: 中文, 英语
深度学习
计算生物
药物筛选
药物设计
小分子
抗体设计
酶设计
蛋白-药物相互作用
蛋白-蛋白相互作用
蛋白-核酸相互作用
Areas of Focus
- 基于深度学习和计算生物的药物筛选设计
Work Experience
- 2018.7-2022.2 - 中国科学院深圳先进技术研究院 - 博士后和助理研究员
- 2022.2-至今 - 中国科学院深圳先进技术研究院 - 副研究员
Academic Background & Achievements
- 2016.9-2010.6 生物工程专业本科: 江西中医药大学
- 2010.9-2013.6 遗传专业, 生物信息学方向硕士: 厦门大学
- 2014.1-2018.6 计算生物专业博士: 南洋理工大学
Publications
- Revolutionizing GPCR-Ligand Predictions: DeepGPCR with experimental Validation for High-Precision Drug Discovery, 张海平, Hongjie Fan, Jixia Wang, Tao Hou, Konda Mani Saravanan, Wei Xia, Hei Wun Kan, Junxin Li, John Z.H. Zhang, Xinmiao Liang, Yang Chen, 2024
- Deep Learning-Based Construction of a Drug-Like Compound Database and Its Application in Virtual Screening of HsDHODH Inhibitors, Wei Xia, Jin Xiao, Hengwei Bian, Jiajun Zhang, John Z.H., Zhang, 张海平, 2024
- A deep learning based multi-model approach for predicting drug-like chemical compound's toxicity, Konda Mani Saravanan, Jiang-Fan Wan, Liujiang Dai, Jiajun Zhang, John Z.H. Zhang, 张海平, 2024
- Advances in Deep Learning Assisted Drug Discovery Methods: A Self-review, 张海平, Konda Mani Saravanan, 2024
- DeepBindGCN: Integrating Molecular Vector Representation with Graph Convolutional Neural Networks for Protein-Ligand Interaction Prediction, 张海平, Konda Mani Saravanan, John Z.H. Zhang, 2023
- Deep Learning-Based Bioactive Therapeutic Peptide Generation and Screening, 张海平, Konda Mani Saravanan, Wei Yanjie, Jiao Yang, Yang Yang, Pan Yi, Wu Xuli, John Z.H. Zhang, 2023
- Validation of Deep Learning-Based DFCNN in Extremely Large-Scale Virtual Screening and Application in Trypsin I Protease Inhibitor Discovery, 张海平, Lin Xiao, Wei Yanjie, Zhang Huiling, Liao Linbu, Wu Hao, Pan Yi, Wu Xuli, 2022
- Generating and screening de novo compounds against given targets using ultrafast deep learning models as core components, 张海平, Saravanan Konda Mani, Yang Yang, Wei Yanjie, Yi Pan, John Z.H. Zhang, 2022
- DeepBindBC: A practical deep learning method for identifying native-like protein-ligand complexes in virtual screening, 张海平, Zhang Tingting, Saravanan Konda Mani, Liao Linbu, Wu Hao, Zhang Haishan, Zhang Huiling, Pan Yi, Wu Xuli, Wei Yanjie, 2022
- An Integrated Deep Learning and Molecular Dynamics Simulation-Based Screening Pipeline Identifies Inhibitors of a New Cancer Drug Target TIPE2, 张海平, Li Junxin, Saravanan Konda Mani, Wu Hao, Wang Zhichao, Wu Du, Wei Yanjie, Lu Zhen, Chen Youhai H, Wan Xiaochun, Pan Yi, 2021
- On the Conformational Dynamics of β-Amyloid Forming Peptides: A Computational Perspective, Konda Mani Saravanan, 张海平, Zhang Huiling, Wenhui Xi, Yanjie Wei, 2020
- DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation, 张海平, Saravanan Konda Manu, Lin Jinzhi, Liao Linbu, Ng Justin TzeYang, Zhou Jiaxiu, Wei Yanjie, 2020
- Investigating the stability of dengue virus envelope protein dimer using well-tempered metadynamics simulations, 张海平, Kai Eric L J, Lu Lanyuan, 2020
- Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov, 张海平, Yang Yang, Li Junxin, Wang Min, Saravanan Konda Mani, Wei Jinli, Ng Justin TzeYang, Hossain Md Tofazzal, Liu Maoxuan, Zhang Huiling, Ren Xiaohu, Pan Yi, Peng Yin, Shi Yi, Wan Xiaochun, Liu Yingxia, Wei Yanjie, 2020
- A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro, 张海平, Yang Yang, Li Junxin, Wang Min, Saravanan Konda Mani, Wei Jinli, Ng Justin TzeYang, Hossain Md Tofazzal, Liu Maoxuan, Zhang Huiling, Ren Xiaohu, Pan Yi, Peng Yin, Shi Yi, Wan Xiaochun, Liu Yingxia, Wei Yanjie, 2020
- Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation, Yang Longhe, Ji Chunyan, Li Yitian, Hu Fan, Zhang Fang, 张海平, Li Long, Ren Jie, Wang Zhaokai, Qiu Yan, 2020
