Professor | 陈捷凯 | 数字化转型顾问

Name	陈捷凯
Contact Information	chen_jiekai@gibh.ac.cn
Language ability	中文, 英语
Province	广东

Name

陈捷凯

Contact Information

chen_jiekai@gibh.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2002-2006 学士: 中山大学 2006-2011 博士: 中国科学院广州生物医药与健康研究院
Work Experience	2011-2013 - 中国科学院广州生物医药与健康研究院 - 副研究员 2013至今 - 中国科学院广州生物医药与健康研究院 - 研究员
Awards	国家自然科学奖二等奖国家级人才项目入选者国家自然科学基金优秀青年广东省特支计划领军人才广东省自然科学基金杰出青年广东省科学技术一等奖（2015）广州市科学技术一等奖（2015）中国科学院杰出成就奖（团队）南粤创新奖（2016）中国科学院卓越青年科学家

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2002-2006 学士: 中山大学
2006-2011 博士: 中国科学院广州生物医药与健康研究院

Work Experience

2011-2013 - 中国科学院广州生物医药与健康研究院 - 副研究员
2013至今 - 中国科学院广州生物医药与健康研究院 - 研究员

Awards

国家自然科学奖二等奖
国家级人才项目入选者
国家自然科学基金优秀青年
广东省特支计划领军人才
广东省自然科学基金杰出青年
广东省科学技术一等奖（2015）
广州市科学技术一等奖（2015）
中国科学院杰出成就奖（团队）
南粤创新奖（2016）
中国科学院卓越青年科学家

Areas of Focus	细胞命运决定的分子机制表观遗传调控与信号转导计算生物学与大数据分析干细胞诱导与分化
Publications	The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, Jiadong Liu, Mingwei Gao, Jiangping He, Kaixin Wu, Siyuan Lin, Lingmei Jin, Jiekai Chen, 2021 Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE, Jiangping He, Andrew P. Hutchins, Jiekai Chen, 2021 Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, Feng-Liang Liu, Kaixin Wu, Jiaoyang Sun, Zilei Duan, Xiongzhi Quan, Guangming Wu, Yong-Tang Zheng, Jiekai Chen, 2021 COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Xianwen Ren, Wen Wen, Xiaoying Fan, Hongyang Wang, Bing Su, Zheng Zhang, Kun Qu, Xiaoqun Wang, Jiekai Chen, Ronghua Jin, Zemin Zhang, 2021 SETDB1-Mediated Cell Fate Transition between 2C- Like and Pluripotent States, Kaixin Wu, He Liu, Yaofeng Wang, Jiangping He, Jiekai Chen, 2020 YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Jiadong Liu, Mingwei Gao, Jiekai Chen, 2020 Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity, Jiekai Chen, 2020 Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients, Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen, 2020 Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming, Xiaowei Lai, Qian Li, Fang Wu, Jiechun Lin, Jiekai Chen, Hui Zheng, Lin Guo, 2020 Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Linlin Hou, Yuanjie Wei, Jiekai Chen, Xichen Bao, Ralf Jauch, 2020 Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment, Jing Sun, Zhen Zhuang, Jian Zheng, Jiekai Chen, Yimin Li, Nanshan Zhong, David K. Meyerholz, Paul B. McCray, Jr., Stanley Perlman, Jincun Zhao, 2020 BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling, Shengyong Yu, Chunhua Zhou, Shangtao Cao, Jiangping He, Jiekai Chen, Jing Liu, Duanqing Pei, 2020 Resolving Cell Fate Decisions during Somatic Cell Reprogramming

Areas of Focus

细胞命运决定的分子机制
表观遗传调控与信号转导
计算生物学与大数据分析
干细胞诱导与分化

Publications

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, Jiadong Liu, Mingwei Gao, Jiangping He, Kaixin Wu, Siyuan Lin, Lingmei Jin, Jiekai Chen, 2021
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE, Jiangping He, Andrew P. Hutchins, Jiekai Chen, 2021
Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, Feng-Liang Liu, Kaixin Wu, Jiaoyang Sun, Zilei Duan, Xiongzhi Quan, Guangming Wu, Yong-Tang Zheng, Jiekai Chen, 2021
COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Xianwen Ren, Wen Wen, Xiaoying Fan, Hongyang Wang, Bing Su, Zheng Zhang, Kun Qu, Xiaoqun Wang, Jiekai Chen, Ronghua Jin, Zemin Zhang, 2021
SETDB1-Mediated Cell Fate Transition between 2C- Like and Pluripotent States, Kaixin Wu, He Liu, Yaofeng Wang, Jiangping He, Jiekai Chen, 2020
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Jiadong Liu, Mingwei Gao, Jiekai Chen, 2020
Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity, Jiekai Chen, 2020
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients, Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen, 2020
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming, Xiaowei Lai, Qian Li, Fang Wu, Jiechun Lin, Jiekai Chen, Hui Zheng, Lin Guo, 2020
Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Linlin Hou, Yuanjie Wei, Jiekai Chen, Xichen Bao, Ralf Jauch, 2020
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment, Jing Sun, Zhen Zhuang, Jian Zheng, Jiekai Chen, Yimin Li, Nanshan Zhong, David K. Meyerholz, Paul B. McCray, Jr., Stanley Perlman, Jincun Zhao, 2020
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling, Shengyong Yu, Chunhua Zhou, Shangtao Cao, Jiangping He, Jiekai Chen, Jing Liu, Duanqing Pei, 2020
Resolving Cell Fate Decisions during Somatic Cell Reprogramming

细胞命运表观遗传学信号转导干细胞 Ipsc 分子调控计算生物学大数据分化重编程

舒红兵 - 武汉大学

徐进新 - 中国科学院大学

Area of Focus
表观遗传学 | 调控 | 发育 | 癌症 | 机制 | 囊泡运输 | 信号转导 | 生物大分子 | 疾病 | 治疗

张小飞 - 中国科学院大学

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