Areas of Focus
- 细胞命运决定的分子机制
- 表观遗传调控与信号转导
- 计算生物学与大数据分析
- 干细胞诱导与分化
Work Experience
- 2011-2013 - 中国科学院广州生物医药与健康研究院 - 副研究员
- 2013至今 - 中国科学院广州生物医药与健康研究院 - 研究员
Academic Background & Achievements
- 2002-2006 学士: 中山大学
- 2006-2011 博士: 中国科学院广州生物医药与健康研究院
Publications
- The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, Jiadong Liu, Mingwei Gao, Jiangping He, Kaixin Wu, Siyuan Lin, Lingmei Jin, Jiekai Chen, 2021
- Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE, Jiangping He, Andrew P. Hutchins, Jiekai Chen, 2021
- Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, Feng-Liang Liu, Kaixin Wu, Jiaoyang Sun, Zilei Duan, Xiongzhi Quan, Guangming Wu, Yong-Tang Zheng, Jiekai Chen, 2021
- COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Xianwen Ren, Wen Wen, Xiaoying Fan, Hongyang Wang, Bing Su, Zheng Zhang, Kun Qu, Xiaoqun Wang, Jiekai Chen, Ronghua Jin, Zemin Zhang, 2021
- SETDB1-Mediated Cell Fate Transition between 2C- Like and Pluripotent States, Kaixin Wu, He Liu, Yaofeng Wang, Jiangping He, Jiekai Chen, 2020
- YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Jiadong Liu, Mingwei Gao, Jiekai Chen, 2020
- Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity, Jiekai Chen, 2020
- Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients, Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen, 2020
- Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming, Xiaowei Lai, Qian Li, Fang Wu, Jiechun Lin, Jiekai Chen, Hui Zheng, Lin Guo, 2020
- Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Linlin Hou, Yuanjie Wei, Jiekai Chen, Xichen Bao, Ralf Jauch, 2020
- Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment, Jing Sun, Zhen Zhuang, Jian Zheng, Jiekai Chen, Yimin Li, Nanshan Zhong, David K. Meyerholz, Paul B. McCray, Jr., Stanley Perlman, Jincun Zhao, 2020
- BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling, Shengyong Yu, Chunhua Zhou, Shangtao Cao, Jiangping He, Jiekai Chen, Jing Liu, Duanqing Pei, 2020
- Resolving Cell Fate Decisions during Somatic Cell Reprogramming
Awards
- 国家自然科学奖二等奖
- 国家级人才项目入选者
- 国家自然科学基金优秀青年
- 广东省特支计划领军人才
- 广东省自然科学基金杰出青年
- 广东省科学技术一等奖（2015）
- 广州市科学技术一等奖（2015）
- 中国科学院杰出成就奖（团队）
- 南粤创新奖（2016）
- 中国科学院卓越青年科学家
