Areas of Focus
- 以NMR技术和计算机分子模拟技术为主要手段研究蛋白质与蛋白质之间、药物靶标蛋白质与小分子之间的相互作用；与疾病相关的NMR代谢组学研究
Work Experience
- 2010-10 - 今 - 中国科学院上海药物研究所 - 研究员
- 2008-05 - 2010-02 - 美国明尼苏达大学 - 研究助理教授
- 2004-05 - 2008-05 - 美国明尼苏达大学 - 博士后
- 2003-08 - 2004-05 - 中国科学院上海有机化学研究所 - 科研人员
Academic Background & Achievements
- 1994.9 - 1998.7 理学学士 药物化学: 北京医科大学
- 1998.9 - 2003.7 理学博士 结构生物学: 中国科学院上海有机化学研究所
- 2004.5 - 2008.6 博士后研究: 美国明尼苏达大学
Publications
- Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation, Zhou, Chen, Zhang, Jingjing, Luo, Xinwen, Lian, Fulin, Zeng, Yangyang, Zhang, Zhenqing, Zhang, Haiyan, Zhang, Naixia, 2023
- Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, Gao, Jing, Zhou, Chen, Zhong, Yan, Shi, Li, Luo, Xuanyang, Su, Haixia, Li, Minjun, Xu, Yechun, Zhang, Naixia, Zhou, Hu, 2023
- Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment, Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng, 2023
- Structure-based discovery of potent USP28 inhibitors derived from Vismodegib, Di Zhou, Zhuo Xu, Yaodong Huang, Hui Wang, Xiaoli Zhu, Wentao Zhang, Weiwei Song, Tong Gao, Tongchao Liu, Meng Wang, Li Shi, Naixia Zhang, Bing Xiong, 2023
- Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1, Zhu, Mengying, Wang, Hui, Ding, Yiluan, Yang, Yuanyuan, Xu, Zhuo, Shi, Li, Zhang, Naixia, 2022
- High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases, Xiao, Senhao, Guo, Siqi, Han, Jie, Sun, Yanli, Wang, Mingchen, Chen, Yantao, Fang, Xueyu, Yang, Feng, Mu, Yajuan, Zhang, Liang, Ding, Yiluan, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Luo, Cheng, Chen, Shijie, 2022
- Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis, Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong, 2022
- Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule, Lan, Xiaofang, Olaleye, Olajide E, Lu, Junlan, Yang, Wei, Du, Feifei, Yang, Junling, Cheng, Chen, Shi, Yanhong, Wang, Fengqing, Zeng, Xueshan, Tian, Nannan, Liao, Peiwei, Yu, Xuan, Xu, Fang, Li, Yingfei, Wang, Hongtao, Zhang, Naixia, Jia, Weiwei, Li, Chuan, 2021
- 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, Wang, Shuni, Yang, Hong, Su, Mingbo, Lian, Fulin, Cong, Zhanqing, Wei, Rongrui, Zhou, Yubo, Li, Xingjun, Zheng, Xingling, Li, Chunpu, Fu, Xuhong, Han, Xu, Shi, Qiongyu, Li, Cong, Zhang, Naixia, Geng, Meiyu, Liu, Hong, Li, Jia, Huang, Xun, Wang, Jiang, 2021
- Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis (vol 89, pg 631, 2020), Liu, Xia, Ruan, Zhi, Shao, Xingcheng, Feng, Hongxuan, Wu, Lei, Wang, Wei, Wang, Hongmin, Mu, Hongyan, Zhang, Rujun, Zhao, Weimin, Zhang, Haiyan, Zhang, Naixia, 2021
