Professor | 张乃霞 | 数字化转型顾问

Name	张乃霞
Contact Information	nxzhang@mail.shcnc.ac.cn
Language ability	中文, 英语
Province	上海

Name

张乃霞

Contact Information

nxzhang@mail.shcnc.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1994.9 - 1998.7 理学学士药物化学: 北京医科大学 1998.9 - 2003.7 理学博士结构生物学: 中国科学院上海有机化学研究所 2004.5 - 2008.6 博士后研究: 美国明尼苏达大学
Work Experience	2010-10 - 今 - 中国科学院上海药物研究所 - 研究员 2008-05 - 2010-02 - 美国明尼苏达大学 - 研究助理教授 2004-05 - 2008-05 - 美国明尼苏达大学 - 博士后 2003-08 - 2004-05 - 中国科学院上海有机化学研究所 - 科研人员

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1994.9 - 1998.7 理学学士药物化学: 北京医科大学
1998.9 - 2003.7 理学博士结构生物学: 中国科学院上海有机化学研究所
2004.5 - 2008.6 博士后研究: 美国明尼苏达大学

Work Experience

2010-10 - 今 - 中国科学院上海药物研究所 - 研究员
2008-05 - 2010-02 - 美国明尼苏达大学 - 研究助理教授
2004-05 - 2008-05 - 美国明尼苏达大学 - 博士后
2003-08 - 2004-05 - 中国科学院上海有机化学研究所 - 科研人员

Areas of Focus	以NMR技术和计算机分子模拟技术为主要手段研究蛋白质与蛋白质之间、药物靶标蛋白质与小分子之间的相互作用；与疾病相关的NMR代谢组学研究
Publications	Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation, Zhou, Chen, Zhang, Jingjing, Luo, Xinwen, Lian, Fulin, Zeng, Yangyang, Zhang, Zhenqing, Zhang, Haiyan, Zhang, Naixia, 2023 Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, Gao, Jing, Zhou, Chen, Zhong, Yan, Shi, Li, Luo, Xuanyang, Su, Haixia, Li, Minjun, Xu, Yechun, Zhang, Naixia, Zhou, Hu, 2023 Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment, Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng, 2023 Structure-based discovery of potent USP28 inhibitors derived from Vismodegib, Di Zhou, Zhuo Xu, Yaodong Huang, Hui Wang, Xiaoli Zhu, Wentao Zhang, Weiwei Song, Tong Gao, Tongchao Liu, Meng Wang, Li Shi, Naixia Zhang, Bing Xiong, 2023 Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1, Zhu, Mengying, Wang, Hui, Ding, Yiluan, Yang, Yuanyuan, Xu, Zhuo, Shi, Li, Zhang, Naixia, 2022 High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases, Xiao, Senhao, Guo, Siqi, Han, Jie, Sun, Yanli, Wang, Mingchen, Chen, Yantao, Fang, Xueyu, Yang, Feng, Mu, Yajuan, Zhang, Liang, Ding, Yiluan, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Luo, Cheng, Chen, Shijie, 2022 Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis, Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong, 2022 Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule, Lan, Xiaofang, Olaleye, Olajide E, Lu, Junlan, Yang, Wei, Du, Feifei, Yang, Junling, Cheng, Chen, Shi, Yanhong, Wang, Fengqing, Zeng, Xueshan, Tian, Nannan, Liao, Peiwei, Yu, Xuan, Xu, Fang, Li, Yingfei, Wang, Hongtao, Zhang, Naixia, Jia, Weiwei, Li, Chuan, 2021 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, Wang, Shuni, Yang, Hong, Su, Mingbo, Lian, Fulin, Cong, Zhanqing, Wei, Rongrui, Zhou, Yubo, Li, Xingjun, Zheng, Xingling, Li, Chunpu, Fu, Xuhong, Han, Xu, Shi, Qiongyu, Li, Cong, Zhang, Naixia, Geng, Meiyu, Liu, Hong, Li, Jia, Huang, Xun, Wang, Jiang, 2021 Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis (vol 89, pg 631, 2020), Liu, Xia, Ruan, Zhi, Shao, Xingcheng, Feng, Hongxuan, Wu, Lei, Wang, Wei, Wang, Hongmin, Mu, Hongyan, Zhang, Rujun, Zhao, Weimin, Zhang, Haiyan, Zhang, Naixia, 2021

Areas of Focus

以NMR技术和计算机分子模拟技术为主要手段研究蛋白质与蛋白质之间、药物靶标蛋白质与小分子之间的相互作用；与疾病相关的NMR代谢组学研究

Publications

Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation, Zhou, Chen, Zhang, Jingjing, Luo, Xinwen, Lian, Fulin, Zeng, Yangyang, Zhang, Zhenqing, Zhang, Haiyan, Zhang, Naixia, 2023
Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, Gao, Jing, Zhou, Chen, Zhong, Yan, Shi, Li, Luo, Xuanyang, Su, Haixia, Li, Minjun, Xu, Yechun, Zhang, Naixia, Zhou, Hu, 2023
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment, Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng, 2023
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib, Di Zhou, Zhuo Xu, Yaodong Huang, Hui Wang, Xiaoli Zhu, Wentao Zhang, Weiwei Song, Tong Gao, Tongchao Liu, Meng Wang, Li Shi, Naixia Zhang, Bing Xiong, 2023
Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1, Zhu, Mengying, Wang, Hui, Ding, Yiluan, Yang, Yuanyuan, Xu, Zhuo, Shi, Li, Zhang, Naixia, 2022
High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases, Xiao, Senhao, Guo, Siqi, Han, Jie, Sun, Yanli, Wang, Mingchen, Chen, Yantao, Fang, Xueyu, Yang, Feng, Mu, Yajuan, Zhang, Liang, Ding, Yiluan, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Luo, Cheng, Chen, Shijie, 2022
Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis, Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong, 2022
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule, Lan, Xiaofang, Olaleye, Olajide E, Lu, Junlan, Yang, Wei, Du, Feifei, Yang, Junling, Cheng, Chen, Shi, Yanhong, Wang, Fengqing, Zeng, Xueshan, Tian, Nannan, Liao, Peiwei, Yu, Xuan, Xu, Fang, Li, Yingfei, Wang, Hongtao, Zhang, Naixia, Jia, Weiwei, Li, Chuan, 2021
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, Wang, Shuni, Yang, Hong, Su, Mingbo, Lian, Fulin, Cong, Zhanqing, Wei, Rongrui, Zhou, Yubo, Li, Xingjun, Zheng, Xingling, Li, Chunpu, Fu, Xuhong, Han, Xu, Shi, Qiongyu, Li, Cong, Zhang, Naixia, Geng, Meiyu, Liu, Hong, Li, Jia, Huang, Xun, Wang, Jiang, 2021
Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis (vol 89, pg 631, 2020), Liu, Xia, Ruan, Zhi, Shao, Xingcheng, Feng, Hongxuan, Wu, Lei, Wang, Wei, Wang, Hongmin, Mu, Hongyan, Zhang, Rujun, Zhao, Weimin, Zhang, Haiyan, Zhang, Naixia, 2021

Nmr 分子模拟蛋白质相互作用药物靶标小分子代谢组学疾病研究结构生物学生物化学计算生物学

傅青山 - 中国科学院大学

Area of Focus
Hiv-1 | 包膜蛋白 | 膜融合 | 药物设计 | 药理学 | 抗病毒 | Nmr | 结构生物学 | 研究 | 创新

于坤千 - 中国科学院大学

曾臣 - 南方科技大学

Area of Focus
糖化学 | 糖蛋白 | 多肽 | 药物 | 有机 | 小分子 | 探针 | 合成 | 生物化学 | 化学生物学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们