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张青
Medical School
南京大学
江苏
Language: 英语, 中文
Hedgehog
信号转导
泛素化
去泛素化
线粒体
溶酶体
遗传学
生物化学
分子生物学
果蝇
Areas of Focus
- Hedgehog信号转导调节研究
- 线粒体疾病机制研究
- 溶酶体疾病机制研究
Work Experience
- 2003-2009 - 美国德克萨斯大学西南医学中心 - 博士后研究员
- 2009-至今 - 南京大学模式动物研究所 - 教授和博士生导师
Academic Background & Achievements
- 2002 - 理学博士: 复旦大学
- 2003-2009 - 发育生物学博士后研究: 美国德克萨斯大学西南医学中心
Publications
- Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination, Zhang Q, Jiang J., 2021
- E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation, Jiang W, Yao X, Shan Z, Li W, Gao Y, Zhang Q., 2019
- The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened, Zhou Z, Yao X, Pang S, Chen P, Jiang W, Shan Z, Zhang Q., 2018
- Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A, Chen P, Zhou Z, Yao X, Pang S, Liu M, Jiang W, Jiang J, Zhang Q., 2017
- Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling, Zhou Z, Yao X, Li S, Xiong Y, Dong X, Zhao Y, Jiang J, Zhang Q., 2015
- Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation, An J, Ren S, Murphy S, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling G, Cheng L, Sukov W, Karnes R, Vasmatzis G, Zhang Q, Zhang J, Cheville J, Yan J, Sun Y, Huang H., 2015
- Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila, Liu C, Zhou Z, Chen P, Su MY, Chang CJ, Yan J, Jiang J, Zhang Q., 2014
- Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase, Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J., 2009
- The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control, Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J., 2008
- A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor, Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J., 2006
- Phosphorylation of Cubitus interruptus by Double-time/CKIe and CKIa targets it for Slimb/b-TRCP mediated proteolytic processing, Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J., 2005
