Professor | 徐沁 | 数字化转型顾问

Name	徐沁
Contact Information	xuqin523@sjtu.edu.cn
Language ability	英语, 汉语
Province	上海

Name

徐沁

Contact Information

xuqin523@sjtu.edu.cn

Language ability

英语, 汉语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	2001 北京大学生物学士学位 2008 美国田纳西大学生物博士学位 2009 美国田纳西大学统计学硕士双学位
Work Experience	2010-2012 田纳西大学/橡树岭国家实验室分子生物物理中心进行博士后研究 2013至今上海交通大学生命科学技术学院副研究员 2018年兼职浙江大学台州研究院材料科学与技术研究所特聘研究员 2019年兼职上海交通大学-耶鲁大学生物统计和数据科学联合中心研究员
Awards	2017.10 浙江台州市“500精英”人才

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

2001 北京大学生物学士学位
2008 美国田纳西大学生物博士学位
2009 美国田纳西大学统计学硕士双学位

Work Experience

2010-2012 田纳西大学/橡树岭国家实验室分子生物物理中心进行博士后研究
2013至今上海交通大学生命科学技术学院副研究员
2018年兼职浙江大学台州研究院材料科学与技术研究所特聘研究员
2019年兼职上海交通大学-耶鲁大学生物统计和数据科学联合中心研究员

Awards

2017.10 浙江台州市“500精英”人才

Areas of Focus	计算结构生物学生物物理学生物统计学
Publications	An Allosteric Regulation Mechanism of Arabidopsis Serine/Threonine Kinase 1 (SIK1) Through Phosphorylation, Junxi Mu, Jiali Zhou, Qingqiu Gong, Qin Xu, 2022 SPVec: A Word2vec-inspired feature representation method for Drug-Target Interaction Prediction, Yu-Fang Zhang, Xiangeng Wang, Aman Chandra Kaushik, Yanyi Chu, Xiaoqi Shan, Ming-Zhu Zhao, Qin Xu, Dong-Qing Wei, 2020 The disulfide bond between Cys22 and Cys27 in the protease domain modulate clotting activity of coagulation factor X, Fang Li, Changming Chen, Si-Ying Qu, Ming-Zhu Zhao, Xiaoling Xie, Xi Wu, Lei Li, Xuefeng Wang, Qiulan Ding, Qin Xu, Dong-Qing Wei, Wenman Wu, 2019 Theoretical Studies of Intracellular Concentration of Micro-organisms’ Metabolites, Hai-Feng Yang, Xiao-Nan Zhang, Yan Li, Yong-Hong Zhang, Qin Xu, Dong-Qing Wei, 2017 The dynamic binding of cholesterol to the multiple sites of C99: as revealed by coarse-grained and all-atom simulations, Cheng-Dong Li, Qin Xu, Ruo-Xu Gu, Jing Qu, Dong-Qing Wei, 2017 Passive Transmembrane Permeation Mechanisms of Monovalent Ions Explored by Molecular Dynamics Simulations, Hui-Yuan Zhang, Qin Xu, Yu-Kun Wang, Tang-Zhen Zhao, Dan Hu, Dong-Qing Wei, 2016 The Destabilization of Alzheimer's Aβ42 Protofibrils with a Novel Drug Candidate wgx-50 by Molecular Dynamics Simulations, Huai-Meng Fan, Ruo-Xu Gu, Yan-Jing Wang, Yun-Long Pi, Yong-Hong Zhang, Qin Xu, Dong-Qing Wei, 2015 Energy Triplets for Writing Epigenetic Marks: Insights from QM/MM Free-Energy Simulations of Protein Lysine Methyltransferases, Qin Xu, Yu-Zhuo Chu, Hao-Bo Guo, Jeremy C. Smith, Hong Guo, 2009 The Importance of Dynamics in Substrate-Assisted Catalysis and Specificity, Qin Xu, Haobo Guo, Alexander Wlodawer, Hong Guo, 2006 Origin of Tight Binding of a Near-Perfect Transition-State Analogue by Cytidine Deaminase: Implications for Enzyme Catalysis, Haobo Guo, Niny Rao, Qin Xu, Hong Guo, 2005

Areas of Focus

计算结构生物学
生物物理学
生物统计学

Publications

An Allosteric Regulation Mechanism of Arabidopsis Serine/Threonine Kinase 1 (SIK1) Through Phosphorylation, Junxi Mu, Jiali Zhou, Qingqiu Gong, Qin Xu, 2022
SPVec: A Word2vec-inspired feature representation method for Drug-Target Interaction Prediction, Yu-Fang Zhang, Xiangeng Wang, Aman Chandra Kaushik, Yanyi Chu, Xiaoqi Shan, Ming-Zhu Zhao, Qin Xu, Dong-Qing Wei, 2020
The disulfide bond between Cys22 and Cys27 in the protease domain modulate clotting activity of coagulation factor X, Fang Li, Changming Chen, Si-Ying Qu, Ming-Zhu Zhao, Xiaoling Xie, Xi Wu, Lei Li, Xuefeng Wang, Qiulan Ding, Qin Xu, Dong-Qing Wei, Wenman Wu, 2019
Theoretical Studies of Intracellular Concentration of Micro-organisms’ Metabolites, Hai-Feng Yang, Xiao-Nan Zhang, Yan Li, Yong-Hong Zhang, Qin Xu, Dong-Qing Wei, 2017
The dynamic binding of cholesterol to the multiple sites of C99: as revealed by coarse-grained and all-atom simulations, Cheng-Dong Li, Qin Xu, Ruo-Xu Gu, Jing Qu, Dong-Qing Wei, 2017
Passive Transmembrane Permeation Mechanisms of Monovalent Ions Explored by Molecular Dynamics Simulations, Hui-Yuan Zhang, Qin Xu, Yu-Kun Wang, Tang-Zhen Zhao, Dan Hu, Dong-Qing Wei, 2016
The Destabilization of Alzheimer's Aβ42 Protofibrils with a Novel Drug Candidate wgx-50 by Molecular Dynamics Simulations, Huai-Meng Fan, Ruo-Xu Gu, Yan-Jing Wang, Yun-Long Pi, Yong-Hong Zhang, Qin Xu, Dong-Qing Wei, 2015
Energy Triplets for Writing Epigenetic Marks: Insights from QM/MM Free-Energy Simulations of Protein Lysine Methyltransferases, Qin Xu, Yu-Zhuo Chu, Hao-Bo Guo, Jeremy C. Smith, Hong Guo, 2009
The Importance of Dynamics in Substrate-Assisted Catalysis and Specificity, Qin Xu, Haobo Guo, Alexander Wlodawer, Hong Guo, 2006
Origin of Tight Binding of a Near-Perfect Transition-State Analogue by Cytidine Deaminase: Implications for Enzyme Catalysis, Haobo Guo, Niny Rao, Qin Xu, Hong Guo, 2005

分子模拟蛋白质复合物催化机制结构功能关系调控原理分子运动水分子带电离子磷脂分子人工智能

魏冬青 - 上海交通大学

魏冬青 - 上海交通大学

徐沁 - 上海交通大学

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