Areas of Focus
- 非编码RNA在组织稳态和肿瘤发生发展中的作用和调控机制
- 造血稳态和白血病发生发展中的细胞间通讯和免疫细胞调控网络
Work Experience
- 2009.2-2012.4 - 芝加哥大学医学院血液与肿瘤部 - 博士后
- 2012.5-2013.12 - 斯坦福大学医学院心血管研究所 - 博士后
- 2014.1-2020.9 - 武汉大学基础医学院 - 副教授
- 2020.10至今 - 华中农业大学生物医学与健康学院 - 教授
Academic Background & Achievements
- 1999.9-2003.6 学士: 武汉大学生命科学学院, 生物技术
- 2003.9-2008.6 博士: 武汉大学生命科学学院, 细胞生物学
Publications
- circRIP: an accurate tool for identifying circRNA-RBP interactions, Dong X, Chen K, Chen W, Wang J, Chang L, Deng J, Wei L, Han L, Huang C, He C, 2022
- YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation, Li J, Chen K, Dong X, Xu Y, Sun Q, Wang H, Chen Z, Liu C, Liu R, Yang Z, Mei X, Zhang R, Chang L, Tian Z, Chen J, Liang K, He C, Luo M, 2022
- CSCD 2.0: An integrated interactional database of cancer-specific circular RNA, Feng J, Chen W, Dong X, Wang J, Mei X, Deng J, Yang S, Zhuo C, Huang X, Shao L, Zhang R, Guo J, Ma R, Liu J, Li F, Wu Y, Han L, He C, 2021
- ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues, Liu X, Chen W, Fang Y, Yang S, Chang L, Chen X, Ye H, Tang X, Zhong S, Zhang W, Dong Z, Han L, He C, 2021
- Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy, Shao L, Jiang G, Yang X, Zeng M, Cheng J, Kong S, Dong X, Chen T, Han S, Yin J, Liu W, He X, He C, Peng B, 2021
- CircRNA inhibits DNA damage repair by interacting with host gene, Xu X, Zhang J, Tian Y, Gao Y, Dong X, Chen W, Yuan X, Yin W, Xu J, Chen K, He C, Wei L, 2020
- The RNA N(6)-methyladenosine modification landscape of human fetal tissues, Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M, He C, Xia L, 2019
- Genome-wide identification of cancer-specific alternative splicing in circRNA, Feng J, Chen K, Dong X, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C, 2019
- CVm6A: A Visualization and Exploration Database for m6As in Cell Lines, Han Y, Feng J, Xia L, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L, He C, 2019
- CircView: a visualization and exploration tool for circular RNAs, Feng J, Xiang Y, Xia S, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C, Han L, 2018
- Genome-wide characterization of lncRNAs in acute myeloid leukemia, Lei L, Xia S, Liu D, Li X, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L, He C, 2018
- CSCD: A database for cancer-specific circular RNAs, Xia S, Feng J, Chen K, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L, He C, 2018
- Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes, Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C, 2017
- Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart, He C, Hu H, Wilson KD, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC, 2016
- Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study, Li Z, Herold T, He C, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Döhner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J, 2013
- Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution, He C, Li Z, Chen P, Huang H, Hurst LD, Chen J, 2012
- Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia, Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J, 2010
- A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis, He C, Zhou F, Zuo Z, Cheng H, Zhou R, 2009
- GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny, He C, Cheng H, Zhou R, 2007
- Genome-wide detection of testis- and testicular cancer-specific alternative splicing, He C, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H, Zhou R, 2007
Awards
- 武汉大学珞珈青年学者 (2014)
- 武汉大学朱裕璧医学奖 (2014)
- 湖北省人才计划 (2016)
- 湖北省自然科学技术进步奖二等奖 (2021)
