Professor | 韩文元 | 数字化转型顾问

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Name	韩文元
Contact Information	hanwenyuan@mail.hzau.edu.cn
Language ability	中文, 英文
Province	湖北

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Name

韩文元

Contact Information

hanwenyuan@mail.hzau.edu.cn

Language ability

中文, 英文

Province

湖北

University/Lab Affiliation and Title	华中农业大学
Faculty	Life Sciences
Academic Background & Achievements	2004.09-2011.07 理学学士/硕士：山东大学 2011.09-2015.05 理学博士：丹麦哥本哈根大学
Work Experience	2015.08-2017.07 - 丹麦哥本哈根大学 - 博士后 2017.07-2018.03 - 丹麦哥本哈根大学 - 助理教授 2018.09-现在 - 华中农业大学 - 教授

University/Lab Affiliation and Title

华中农业大学

Faculty

Life Sciences

Academic Background & Achievements

2004.09-2011.07 理学学士/硕士：山东大学
2011.09-2015.05 理学博士：丹麦哥本哈根大学

Work Experience

2015.08-2017.07 - 丹麦哥本哈根大学 - 博士后
2017.07-2018.03 - 丹麦哥本哈根大学 - 助理教授
2018.09-现在 - 华中农业大学 - 教授

Areas of Focus	微生物免疫系统基于微生物免疫系统的应用技术
Publications	A short prokaryotic Argonaute activates membrane effector to confer antiviral defense., Zhifeng Zeng, Yu Chen, Rafael Pinilla-Redondo, Shiraz A. Shah, Fen Zhao, Chen Wang, Zeyu Hu, Chang Wu, Changyi Zhang, Rachel J. Whitaker, Qunxin She, Wenyuan Han, 2022 The trans DNA cleavage activity of Cas12a provides no detectable immunity against plasmid or phage., Shunhang Liu, Xichen Rao, Ruiliang Zhao, Wenyuan Han, 2022 A membrane-associated DHH-DHHA1 nuclease degrades type III CRISPR second messenger., Ruiliang Zhao, Yang Yang, Fan Zheng, Zhifeng Zeng, Wenqian Feng, Xuexia Jin, Jiayi Wang, Ke Yang, Yun Xiang Liang, Qunxin She, Wenyuan Han, 2020 Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system., Tong Guo, Fan Zheng, Zhifeng Zeng, Yang Yang, Qi Li, Qunxin She, Wenyuan Han, 2019 A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding., Wenyuan Han, Stefano Stella, Yan Zhang, Tong Guo, Karolina Sulek, Li Peng-Lundgren, Guillermo Montoya, Qunxin She, 2018 Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus., Tong Guo, Wenyuan Han, Qunxin She, 2019 Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail., Wenyuan Han, Saifu Pan, Blanca Lopez-Mendez, Guillermo Montoya, Qunxin She, 2017 A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction., Wenyuan Han, Yingjun Li, Ling Deng, Mingxia Feng, Wenfang Peng, Søren Hallstrøm, Jing Zhang, Nan Peng, Yun Xiang Liang, Malcolm F. White, Qunxin She, 2017 NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus., Wenyuan Han, Yanqun Xu, Xu Feng, Yun Xiang Liang, Li Huang, Yulong Shen, Qunxin She, 2017 Reverse gyrase functions in genome integrity maintenance by protecting DNA breaks in vivo., Wenyuan Han, Xu Feng, Qunxin She, 2017 CRISPR history: discovery, characterization, application and prosperity., Wenyuan Han, Qunxin She, 2017 Nanobiomotors of archaeal DNA repair machineries: current research status and application potential., Wenyuan Han, Yulong Shen, Qunxin She, 2014 Knockouts of RecA-like proteins RadC1 and RadC2 have distinct responses to DNA damage agents in Sulfolobus islandicus., Pengjuan Liang, Wenyuan Han, Qihong Huang, Yanze Li, Jinfeng Ni, Qunxin She, Yulong Shen, 2013

Areas of Focus

微生物免疫系统
基于微生物免疫系统的应用技术

Publications

A short prokaryotic Argonaute activates membrane effector to confer antiviral defense., Zhifeng Zeng, Yu Chen, Rafael Pinilla-Redondo, Shiraz A. Shah, Fen Zhao, Chen Wang, Zeyu Hu, Chang Wu, Changyi Zhang, Rachel J. Whitaker, Qunxin She, Wenyuan Han, 2022
The trans DNA cleavage activity of Cas12a provides no detectable immunity against plasmid or phage., Shunhang Liu, Xichen Rao, Ruiliang Zhao, Wenyuan Han, 2022
A membrane-associated DHH-DHHA1 nuclease degrades type III CRISPR second messenger., Ruiliang Zhao, Yang Yang, Fan Zheng, Zhifeng Zeng, Wenqian Feng, Xuexia Jin, Jiayi Wang, Ke Yang, Yun Xiang Liang, Qunxin She, Wenyuan Han, 2020
Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system., Tong Guo, Fan Zheng, Zhifeng Zeng, Yang Yang, Qi Li, Qunxin She, Wenyuan Han, 2019
A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding., Wenyuan Han, Stefano Stella, Yan Zhang, Tong Guo, Karolina Sulek, Li Peng-Lundgren, Guillermo Montoya, Qunxin She, 2018
Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus., Tong Guo, Wenyuan Han, Qunxin She, 2019
Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail., Wenyuan Han, Saifu Pan, Blanca Lopez-Mendez, Guillermo Montoya, Qunxin She, 2017
A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction., Wenyuan Han, Yingjun Li, Ling Deng, Mingxia Feng, Wenfang Peng, Søren Hallstrøm, Jing Zhang, Nan Peng, Yun Xiang Liang, Malcolm F. White, Qunxin She, 2017
NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus., Wenyuan Han, Yanqun Xu, Xu Feng, Yun Xiang Liang, Li Huang, Yulong Shen, Qunxin She, 2017
Reverse gyrase functions in genome integrity maintenance by protecting DNA breaks in vivo., Wenyuan Han, Xu Feng, Qunxin She, 2017
CRISPR history: discovery, characterization, application and prosperity., Wenyuan Han, Qunxin She, 2017
Nanobiomotors of archaeal DNA repair machineries: current research status and application potential., Wenyuan Han, Yulong Shen, Qunxin She, 2014
Knockouts of RecA-like proteins RadC1 and RadC2 have distinct responses to DNA damage agents in Sulfolobus islandicus., Pengjuan Liang, Wenyuan Han, Qihong Huang, Yanze Li, Jinfeng Ni, Qunxin She, Yulong Shen, 2013

Crispr-Cas9 基因编辑基因表达调控核酸检测病毒入侵质粒入侵免疫机制 Argonaute 细菌古菌

张锐 - 中山大学

姜成英 - 中国科学院大学

Area of Focus
极端环境 | 嗜酸 | 嗜热 | 古菌 | 细菌 | 代谢 | 环境适应 | 生物冶金 | 修复 | 微生物多样性

李洁 - 中国科学院大学

Area of Focus
极端微生物 | 遗传学 | 生理学 | 环境适应 | 厌氧菌 | 基因编辑 | 微生物学 | 古菌 | 产甲烷菌 | 冷适应

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