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张锐
zhangrui3@mail.sysu.edu.cn
英语, 中文
广东
中山大学
Life Sciences
  • 2003 - 学士学位: 四川大学
  • 2009 - 博士学位: 中国科学院昆明动物研究所
  • 2015 - 入选中山大学“百人计划”
  • 2015 - 国家海外高层次人才
  • 2017 - 广东省“珠江人才计划”创新创业团队人才
  • 2009-2011 - 在伦敦皇家学会Stephen Cohen教授实验室和台湾中研院Chung-I Wu教授实验室从事小RNA进化研究
  • 2011-2015 - 在美国斯坦福大学医学院遗传系从事博士后研究
RNA编辑、修饰和RNA治疗
基因编辑用于疾病治疗
  • Epitranscriptomic subtyping, visualization, and denoising by global motif visualization, Jianheng Liu, Tao Huang, Jing Yao, Tianxuan Zhao, Yusen Zhang, Rui Zhang, 2023
  • Patients with Asian-type DEL can safely be transfused using RhD-positive blood, Yanli Ji, Yalin Luo, Jizhi Wen, Yuanfan Sun, Shuangshuang Jia, Chunquan Ou, Wenbing Yang, Jingwang Chen, Hanshen Ye, Xiangfu Liu, Yongneng Liang, Zhigang Lu, Ying Feng, Xinzhong Wu, Muzhou Xiao, Jiankun Mo, Zhenhai Zhou, Zhen Wang, Zhijian Liao, Junhu Chen, Ling Wei, Guangping Luo, Sentot Santoso, Yann Fichou, Willy Albert Flegel, Chaopeng Shao, Chengyao Li, Rui Zhang, Yongshui Fu, 2023
  • Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals, Jianheng Liu, Tao Huang, Wanying Chen, Chenhui Ding, Tianxuan Zhao, Xueni Zhao, Bing Cai, Yusen Zhang, Song Li, Ling Zhang, Maoguang Xue, Xiuju He, Wanzhong Ge, Canquan Zhou, Yanwen Xu, Rui Zhang, 2022
  • Virus-specific editing identification approach reveals the landscape of A-to-I editing and its impacts on SARS-CoV-2 characteristics and evolution, Yulong Song, Xiuju He, Wenbing Yang, Yaoxing Wu, Jun Cui, Tian Tang, Rui Zhang, 2022
  • Sequence- and structure-selective mRNA m5C methylation by NSUN6 in animals, Jianheng Liu, Tao Huang, Yusen Zhang, Tianxuan Zhao, Xueni Zhao, Wanying Chen, Rui Zhang, 2021
  • Human A-to-I RNA editing SNP loci are enriched in GWAS signals for autoimmune diseases and under balancing selection, Hui Zhang, Qiang Fu, Xinrui Shi, Ziqing Pan, Wenbing Yang, Zichao Huang, Tian Tang, Xionglei He, Rui Zhang, 2020
  • irCLASH reveals RNA substrates recognized by human ADARs, Yulong Song, Wenbing Yang, Qiang Fu, Liang Wu, Xueni Zhao, Yusen Zhang, Rui Zhang, 2020
  • Sense-antisense miRNA pairs constitute an elaborate reciprocal regulatory circuit, Yulong Song, Lishi Li, Wenbing Yang, Qiang Fu, Wanying Chen, Zeng Fang, Wen Li, Nannan Gu, Rui Zhang, 2020
  • Dynamic landscape and evolution of m6A methylation in human, Hui Zhang, Xinrui Shi, Tao Huang, Wanying Chen, Nannan Gu, Rui Zhang, 2020
  • A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis, Kun Liao, Shuye Deng, Liyan Xu, Wenfeng Pan, Shiyu Yang, Fufu Zheng, Xingui Wu, Hongrong Hu, Zhijun Liu, Junhang Luo, Rui Zhang, Dong-Ming Kuang, Jiajun Dong, Yi Wu, Hui Zhang, Penghui Zhou, Jin-Xin Bei, Yang Xu, Yin Ji, Peng Wang, Huai-Qiang Ju, Rui-Hua Xu, Bo Li, 2020
  • Genome-wide identification of mRNA 5-methylcytosine in mammals, Tao Huang, Wanying Chen, Jianheng Liu, Nannan Gu, Rui Zhang, 2019
  • The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting, Lishi Li, Yulong Song, Xinrui Shi, Jianheng Liu, Shaolei Xiong, Wanying Chen, Qiang Fu, Zichao Huang, Nannan Gu, Rui Zhang, 2018
  • Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing, Rui Zhang, Patricia Deng, Dionna Jacobson, Jin Billy Li, 2017
  • Dynamic landscape and regulation of RNA editing in mammals, Meng How Tan, Qin Li, 2017
  • Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease, eGTEx Project, 2017
  • Genetic mapping uncovers cis-regulatory landscape of RNA editing, Gokul Ramaswami, Patricia Deng, Rui Zhang, Mary Anne Carbone, Trudy F.C. Mackay, Li Jin Billy, 2015
  • The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers, Leng Han, Lixia Diao, Shuangxing Yu, Xiaoyan Xu, 2015
  • Effect of predicted protein-truncating genetic variants on the human transcriptome, Manuel A Rivas, 2015
  • The landscape of genomic imprinting across diverse adult human tissues, Yael Baran, 2015
  • Genetic conflict reflected in tissue-specific maps of genomic imprinting, Tomas Babak, Brian DeVeale, Emily K Tsang, Yiqi Zhou, Xin Li, Kevin S Smith, Kim R Kukurba, Rui Zhang, Jin Billy Li, Derek van der Kooy, Stephen B Montgomery and Hunter B Fraser, 2015
  • Cis regulatory effects on A-to-I RNA editing in related Drosophila species, Anne L. Sapiro, Patricia Deng, Rui Zhang, Jin Billy Li, 2015
  • Functional conservation of both CDS- and 3’-UTR-located microRNA binding sites between species, Guojing Liu, Rui Zhang, Jin Xu, Chung-I Wu and Xuemei Lu, 2014
  • Allelic expression of deleterious protein-coding variants across human tissues, Kimberly R. Kukurba, Rui Zhang, Xin Li, Kevin S. Smith, David A. Knowles, Meng How Tan, Robert Piskol, Monkol Lek, Michael Snyder, Daniel G. MacArthur, Jin Billy Li and Stephen B. Montgomery, 2014
  • Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing, Rui Zhang, Xin Li, Gokul Ramaswami, Kevin S Smith, Gustavo Turecki, Stephen B Montgomery and Jin Billy Li, 2014
  • Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover, Xin Hong, Hung Thanh Nguyen, Qingfeng Chen, Rui Zhang, Zandra Hagman, P Mathijs and Stephen Cohen, 2014
  • A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes, Lily Bazak, Ami Haviv, Michal Barak, Jasmine Jacob-Hirsch, Patricia Deng, Rui Zhang, Farren J Isaacs, Gideon Rechavi, Jin Billy Li, Eli Eisenberg and Erez Y Levanon, 2013
  • The evolution of evolvability in microRNA target sites in vertebrates, Jin Xu, Rui Zhang, Yang Shen, Guojing Liu, Xuemei Lu and Chung-I Wu, 2013
  • Identifying RNA editing sites using RNA sequencing data alone, Gokul Ramaswami, Rui Zhang, Robert Piskol, Liam P Keegan, Patricia Deng, Mary A O'Connell and Jin Billy Li, 2013
  • Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs, Yang Shen, Yang Lv, Lei Huang, Wensheng Liu, Ming Wen, Tian Tang, Rui Zhang, Eric Hungate, Suhua Shi and Chung-I Wu, 2011
  • Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis, Wanzhong Ge, Yawen Chen, Ruifen Weng, Singfee Lim, Marita Buescher, Rui Zhang and Stephen M. Cohen, 2011
  • Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque, Xiaodong Fang, Yanfeng Zhang, Rui Zhang, Lixin Yang, Ming Li, Kaixiong Ye, Xiaosen Guo, Jun Wang and Bing Su, 2011
  • MicroRNA regulation and the variability of human cortical gene expression, Rui Zhang and Bing Su, 2008
  • Molecular evolution of a primate-specific microRNA family, Rui Zhang, Yinqiu Wang and Bing Su, 2008
  • Rapid evolution of an X-linked microRNA cluster in primates, Rui Zhang, Yi Peng, Wen Wang and Bing Su, 2007
Rna编辑 Rna修饰 Rna治疗 基因编辑 疾病治疗 Crispr-Cas9 遗传疾病 慢性病 肿瘤治疗 生物技术

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