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李博安
nbali@xmu.edu.cn
中文, 英语, 德语
福建
厦门大学
Medical
  • 1986年 - 医学学士学位:第四军医大学
  • 1996年 - 生物化学与分子生物学博士学位:上海肿瘤研究所
  • 1998至2006年 - 德国和美国博士后和高级研究员
  • 2006年至今 - 厦门大学闽江学者特聘教授,博士生导师
  • 2012年至今 - 厦门大学生命科学学院副院长,分子诊断教育部工程研究中心副主任
发育与肿瘤细胞生物学
Wnt信号通路
表观遗传学
干细胞生物学
分子诊断
  • Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells., Zhang R, Hong JJ, Yang Q, Ong CT, Li BA*, Liou YC*., 2018
  • Pygo2 regulates adiposity and glucose homeostasis via β-Catenin-Axin2-GSK3β signaling pathway., Xie YY, Mo CL, Cai YH, Wang WJ, Hong XX, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, and Li BA*., 2018
  • Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer., Lin LY, Yang L, Zeng Q, Wang L, Chen ML, Zhao ZH, Ye GD, Luo QC, Lv PY, Guo QW, Li BA*, Cai JC*, Cai WY*., 2018
  • PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells., Cai W, Chen G, Luo Q, Liu J, Guo X, Zhang T, Ma F, Yuan L, Li BA*, Cai J*., 2017
  • Simultaneous detection of 45 fusion genes in leukemia by dual-color fluorescence real-time PCR., Zheng Z, Zhang P, He G, Liao K, Wang Z, Pan J, Du K, Du J, Li BA*., 2017
  • Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1., Wang ZH, Li Z, Hu M, Yang QJ, Yan S, Wu RS, Li BA*, Guo M*., 2017
  • YAP-TEAD and HNF4α repress reciprocally to regulate hepatocarcinogenesis., Cai WY, Lin LY, Hao H, Zhang SM, Ma F, Hong XX, Zhang H, Liu QF, Ye GD, Sun GB, Liu YJ, Li SN, Xie YY, Cai JC, and Li BA*., 2017
  • Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway., Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ*, and Li BA*., 2016
  • OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors., Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, and Li BA*., 2016
  • MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN)., Zhou W, Shi G, Zhang Q, Wu Q, Li B*, Zhang Z*., 2014
  • Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells., Xu J, Ren G, Zhao DA, Li BA, Cai CF, Zhou Y, Luo XY., 2014
  • Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma., Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM, Li BA*., 2013
  • Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion., Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA*., 2013
  • A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma., Li BA*., 2012
  • The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling., Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*., 2012
  • Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion., Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, Wei T, Zhang L, Yang M, Liu Q, Ye G, Cheng P, Dai X and Li BA*., 2010
  • The role of Pygopus 2 in rat glioma cell growth., Chen YY, Li BA*, Wang HD, Liu XY, Tan GW, Ma YH, Shen SH, Zhu HW, Wang ZX., 2011
  • Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth., Wang ZX, Chen YY, Li BA*, Tan GW, Liu XY, Shen SH, Zhu HW, Wang HD., 2010
  • Cytokeratin expression during mouse embryonic and early postnatal mammary gland development., Sun P, Yuan Y, Li A, Li B, Dai X., 2010
  • Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation., Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and Li BA*, Dai X*., 2009
  • Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation., Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X., 2008
  • Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation., Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M., 2008
  • Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2., Li B*, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X., 2007
  • Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines., Tao P, Xu D, Lin S, Ouyang GL, Chang Y, Chen Q, Yuan Y, Zhuo X, Luo Q, Li J, Li B, Ruan L, Li Q, Li Z., 2007
  • 1'S-1'-Acetoxychavicol acetate (ACA) isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 (HIV-1) by blocking Rev transport., Ye Y, Li B*., 2006
  • Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription., Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X., 2006
  • The mouse Ovol2 gene is required for cranial neural tube development., Mackay DR, Hu M, Li B, Rheaume C, Dai X., 2006
  • Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression., Li B*., Nair, M., Mackay, DR., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, PE., Dai, X., 2005
  • Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1., Yan, HX., Wang, HY., Zhang, R., Chen, L., Li B., Liu, SQ., Cao, HF., Qiu, XH., Shan, YF., Yan, ZH., Wu, HP., Tan, YX., Wu, MC., 2004
  • Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component., Li B*., Mackay, DR., Ma, J., Dai, X., 2004
  • Ovol2, a Mammalian Homolog of Drosophila ovo: Gene Structure, Chromosomal Mapping, and Aberrant Expression in Blind-Sterile Mice., Li B*., Dai, Q., Li, L., Nair, M., Mackey, D., Dai, X., 2002
  • The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation., Li B*., Mackey, DR, Dai, Q., Li, TW., Nair M., Fallahi, M., Schonbaum, CP., Fantes, J., Mahowald, AP., Waterman, ML., Fuchs, E., Dai, X., 2002
发育 肿瘤 细胞生物学 Wnt 信号 表观遗传 干细胞 分子 诊断 生物标志物

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