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张弦
Medical School
厦门大学
福建
Language: 中文, 英语
神经退行性
分子机制
阿尔茨海默病
Β-淀粉样蛋白
蛋白因子
细胞级联反应
分子级联反应
Aβ生成
Aβ转运
Aβ降解
Areas of Focus
- 神经退行性疾病的分子发病机制
- 阿尔茨海默病研究
Work Experience
- 2009-2011 - 厦门大学生物医学研究院 - 助理教授
- 2011-至今 - 厦门大学医学院 - 助理教授
Academic Background & Achievements
- 2000-2004 厦门大学生命科学专业 理学学士
- 2004-2009 厦门大学细胞生物学专业 理学博士
Publications
- SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis, Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H, 2016
- The γ-secretase complex: from structure to function, Zhang X, Li Y, Xu H, Zhang YW, 2014
- Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration, Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, Xu H, 2012
- M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation, Jiang S, Wang Y, Ma Q, Hou H, Zhang X, Zhang Y-w, 2012
- Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing, Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW, 2012
- CutA divalent cation tolerance homolog (E. coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-Site APP cleaving protein 1 (BACE1), Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW, 2012
- Hypoxia inducible factor 1a (HIF-1a)-mediated hypoxia increases BACE1 expression and β-amyloid generation, Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang Y-w, 2007
- Transcriptional regulation of APH-1A and increased γ-secretase cleavage of APP and Notch by HIF-1 and hypoxia, Wang R, Zhang Y-w, Zhang X, Liu R, Zhang X, Hong SH, Xia K, Xia J, Zhang Z, Xu H, 2006
- Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB, Wang R, Zhang Y-W, Sun P, Liu R, Zhang X, Zhang X, Xi JH, Xu H, Zhang Z, 2006
