Professor | 张弦 | 数字化转型顾问

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Name	张弦
Contact Information	xianzhang@xmu.edu.cn
Language ability	中文, 英语
Province	福建

Upload Avatar (500 x 500)

Name

张弦

Contact Information

xianzhang@xmu.edu.cn

Language ability

中文, 英语

Province

福建

University/Lab Affiliation and Title	厦门大学
Faculty	Medical
Academic Background & Achievements	2000-2004 厦门大学生命科学专业理学学士 2004-2009 厦门大学细胞生物学专业理学博士
Work Experience	2009-2011 - 厦门大学生物医学研究院 - 助理教授 2011-至今 - 厦门大学医学院 - 助理教授

University/Lab Affiliation and Title

厦门大学

Faculty

Medical

Academic Background & Achievements

2000-2004 厦门大学生命科学专业理学学士
2004-2009 厦门大学细胞生物学专业理学博士

Work Experience

2009-2011 - 厦门大学生物医学研究院 - 助理教授
2011-至今 - 厦门大学医学院 - 助理教授

Areas of Focus	神经退行性疾病的分子发病机制阿尔茨海默病研究
Publications	SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis, Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H, 2016 The γ-secretase complex: from structure to function, Zhang X, Li Y, Xu H, Zhang YW, 2014 Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration, Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, Xu H, 2012 M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation, Jiang S, Wang Y, Ma Q, Hou H, Zhang X, Zhang Y-w, 2012 Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing, Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW, 2012 CutA divalent cation tolerance homolog (E. coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-Site APP cleaving protein 1 (BACE1), Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW, 2012 Hypoxia inducible factor 1a (HIF-1a)-mediated hypoxia increases BACE1 expression and β-amyloid generation, Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang Y-w, 2007 Transcriptional regulation of APH-1A and increased γ-secretase cleavage of APP and Notch by HIF-1 and hypoxia, Wang R, Zhang Y-w, Zhang X, Liu R, Zhang X, Hong SH, Xia K, Xia J, Zhang Z, Xu H, 2006 Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB, Wang R, Zhang Y-W, Sun P, Liu R, Zhang X, Zhang X, Xi JH, Xu H, Zhang Z, 2006

Areas of Focus

神经退行性疾病的分子发病机制
阿尔茨海默病研究

Publications

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis, Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H, 2016
The γ-secretase complex: from structure to function, Zhang X, Li Y, Xu H, Zhang YW, 2014
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration, Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, Xu H, 2012
M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation, Jiang S, Wang Y, Ma Q, Hou H, Zhang X, Zhang Y-w, 2012
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing, Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW, 2012
CutA divalent cation tolerance homolog (E. coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-Site APP cleaving protein 1 (BACE1), Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW, 2012
Hypoxia inducible factor 1a (HIF-1a)-mediated hypoxia increases BACE1 expression and β-amyloid generation, Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang Y-w, 2007
Transcriptional regulation of APH-1A and increased γ-secretase cleavage of APP and Notch by HIF-1 and hypoxia, Wang R, Zhang Y-w, Zhang X, Liu R, Zhang X, Hong SH, Xia K, Xia J, Zhang Z, Xu H, 2006
Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB, Wang R, Zhang Y-W, Sun P, Liu R, Zhang X, Zhang X, Xi JH, Xu H, Zhang Z, 2006

神经退行性分子机制阿尔茨海默病 Β-淀粉样蛋白蛋白因子细胞级联反应分子级联反应 Aβ生成 Aβ转运 Aβ降解

陶青青 - 浙江大学

高月 - 厦门大学

王鑫 - 厦门大学

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