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丁伟
Life Science
上海交通大学
上海
Language: 中文, 英语, 德语
生物合成
合成生物学
天然产物
极端环境
小分子
酶
酶催化
定向进化
生物催化
微生物菌种
Areas of Focus
- 重要生物活性天然产物的生物合成机制和合成生物学研究
- 极端环境微生物中活性小分子和高效酶的发现
- 酶催化机制的多样性和定向进化研究
- 重要临床药物中间体的生物催化和微生物工业菌种的代谢工程
Work Experience
- 2019-至今：上海交通大学生命科学技术学院，特别研究员、博导
- 2013-2018：兰州大学生命科学院，副教授、硕导
- 2010-2012：德国Saarland University，药物生物技术系，博士后
Academic Background & Achievements
- 2006-2010：兰州大学生命科学院和中科院上海有机化学研究所联合培养，博士
- 2001-2005：兰州大学生命科学院，本科
Publications
- Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding* and Qi Zhang*.Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis, Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding*, Qi Zhang*, 2019
- Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong* and Qi Zhang*. Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation, Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong*, Qi Zhang*, 2018
- Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*. Substrate specificity of the cypemycin decarboxylase CypD, Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*, 2018
- Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding and Qi Zhang. Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases, Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding, Qi Zhang, 2018
- Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*.Expanding the Chemistry of the Class C Radical SAM Methyltransferase NosN by Using an Allyl Analogue of SAM, Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*, 2018
- Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, and Qi Zhang. Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity, Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, Qi Zhang, 2018
- Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf* and Hertweck Christian*. Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species, Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf*, Hertweck Christian*, 2018
- Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu* and Qi Zhang*. Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ, Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu*, Qi Zhang*, 2017
- Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, and Qi Zhang*. Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase, Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, Qi Zhang*, 2017
- Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu and Qi Zhang*. Nucleoside-linked Shunt Products in the Reaction Catalyzed by the Class C Radical S-Adenosylmethionine Methyltransferase NosN, Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu, Qi Zhang*, 2017
