Professor | 杨杰 | 数字化转型顾问

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Name	杨杰
Contact Information	yangjie@hust.edu.cn
Language ability	中文, 英语
Province	湖北省

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Name

杨杰

Contact Information

yangjie@hust.edu.cn

Language ability

中文, 英语

Province

湖北省

University/Lab Affiliation and Title	华中科技大学
Faculty	Life Sciences
Academic Background & Achievements	2007-2013: 华中科技大学博士后 2003-2006: 华中科技大学生物医学工程博士 1998-2001: 华中农业大学作物遗传与育种硕士 1994-1998: 华中农业大学林学学士
Work Experience	2013-2017: Vanderbilt大学, 访问学者 2007-2013: 华中科技大学, 讲师 2001-2003: 生物医药公司, 研发产品
Awards	2008: 华中科技大学优秀博后 2006-2008: 博士后科学基金（3万元） 2008-2011: 国家自然科学基金（20万元） 2008: 湖北省自然科学奖一等奖用于药物筛选和药效评价的光学分子成像动态监测理论与方法研究

University/Lab Affiliation and Title

华中科技大学

Faculty

Life Sciences

Academic Background & Achievements

2007-2013: 华中科技大学博士后
2003-2006: 华中科技大学生物医学工程博士
1998-2001: 华中农业大学作物遗传与育种硕士
1994-1998: 华中农业大学林学学士

Work Experience

2013-2017: Vanderbilt大学, 访问学者
2007-2013: 华中科技大学, 讲师
2001-2003: 生物医药公司, 研发产品

Awards

2008: 华中科技大学优秀博后
2006-2008: 博士后科学基金（3万元）
2008-2011: 国家自然科学基金（20万元）
2008: 湖北省自然科学奖一等奖用于药物筛选和药效评价的光学分子成像动态监测理论与方法研究

Areas of Focus	生物技术：基因工程及蛋白工程，细胞生物学；蛋白结构分析荧光蛋白及细胞成像研究: 荧光蛋白优化；细胞成像；分子探针的设计与构建；利用成像的方法对药物活性进行评价；蛋白质与蛋白质互作成像分析；生物荧光素酶蛋白的成像研究神经生物学：利用光遗传蛋白和钙成像的方法研究神经元环路功能连接；利用改造的狂犬病毒进行神经元环路标记
Publications	Coupling Optogenetic Stimulation with NanoLuc-based Luminescence (BRET) Ca++ Sensing, Jie Yang, Derrick Cumberbatch, Samuel Centanni, Shu-qun Shi, Danny Winder, Donna Webb, Carl Hirschie Johnson, 2016 mBeRFP, an Improved Large Stokes Shift Red Fluorescent Protein, Jie Yang, Liang Wang, Fei Yang, Haiming Luo, Lingling Xu, Jinling Lu, Shaoqun Zeng, Zhihong Zhang, 2013 Low false-positives in an mLumin-based bimolecular fluorescence complementation system with a bicistronic expression vector, Shun Liu, Xiangyong Li, Jie Yang, Zhihong Zhang, 2014 LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells, Liang Wang, Min Chen, Jie Yang, Zhihong Zhang, 2013 Enhanced dynamic range in a genetically encoded Ca2+ sensor, Shun Liu, Jun He, Honglin Jin, Fei Yang, Jinling Lu, Jie Yang, 2011 Tetrameric far-red fluorescent protein as a scaffold to assemble an octavalent peptide nanoprobe for enhanced tumor targeting and intracellular uptake in vivo, Haiming Luo, Jie Yang, Honglin Jin, Chuan Huang, Jianwei Fu, Fei Yang, Hui Gong, Shaoqun Zeng, Qingming Luo, Zhihong Zhang, 2011 A Ligation-independent Cloning Method Using Nicking DNA Endonuclease, Jie Yang, Zhihong Zhang, Xin A Zhang, Qingming Luo, 2010 Recent Progress in Fluorescent Proteins Research, Jie Yang, Zhihong Zhang, Qingming Luo, 2010 Fluorescence imaging to assess the matrix metalloproteinase (MMP) activity and its inhibitor in vivo, Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo, 2008 Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor, Jie Yang, Zhihong Zhang, Juqiang Lin, Jinling Lu, Bi-feng Liu, Shaoqun Zeng, Qingming Luo, 2007 Real-time detecting gelatinases activity in living cells by FRET imaging, Jie Yang, Zhihong Zhang, Bifeng Liu, Qingming Luo, 2006 Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis, Juqing Lin, Zhihong Zhang, Jie Yang, Shaoq

Areas of Focus

生物技术：基因工程及蛋白工程，细胞生物学；蛋白结构分析
荧光蛋白及细胞成像研究: 荧光蛋白优化；细胞成像；分子探针的设计与构建；利用成像的方法对药物活性进行评价；蛋白质与蛋白质互作成像分析；生物荧光素酶蛋白的成像研究
神经生物学：利用光遗传蛋白和钙成像的方法研究神经元环路功能连接；利用改造的狂犬病毒进行神经元环路标记

Publications

Coupling Optogenetic Stimulation with NanoLuc-based Luminescence (BRET) Ca++ Sensing, Jie Yang, Derrick Cumberbatch, Samuel Centanni, Shu-qun Shi, Danny Winder, Donna Webb, Carl Hirschie Johnson, 2016
mBeRFP, an Improved Large Stokes Shift Red Fluorescent Protein, Jie Yang, Liang Wang, Fei Yang, Haiming Luo, Lingling Xu, Jinling Lu, Shaoqun Zeng, Zhihong Zhang, 2013
Low false-positives in an mLumin-based bimolecular fluorescence complementation system with a bicistronic expression vector, Shun Liu, Xiangyong Li, Jie Yang, Zhihong Zhang, 2014
LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells, Liang Wang, Min Chen, Jie Yang, Zhihong Zhang, 2013
Enhanced dynamic range in a genetically encoded Ca2+ sensor, Shun Liu, Jun He, Honglin Jin, Fei Yang, Jinling Lu, Jie Yang, 2011
Tetrameric far-red fluorescent protein as a scaffold to assemble an octavalent peptide nanoprobe for enhanced tumor targeting and intracellular uptake in vivo, Haiming Luo, Jie Yang, Honglin Jin, Chuan Huang, Jianwei Fu, Fei Yang, Hui Gong, Shaoqun Zeng, Qingming Luo, Zhihong Zhang, 2011
A Ligation-independent Cloning Method Using Nicking DNA Endonuclease, Jie Yang, Zhihong Zhang, Xin A Zhang, Qingming Luo, 2010
Recent Progress in Fluorescent Proteins Research, Jie Yang, Zhihong Zhang, Qingming Luo, 2010
Fluorescence imaging to assess the matrix metalloproteinase (MMP) activity and its inhibitor in vivo, Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo, 2008
Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor, Jie Yang, Zhihong Zhang, Juqiang Lin, Jinling Lu, Bi-feng Liu, Shaoqun Zeng, Qingming Luo, 2007
Real-time detecting gelatinases activity in living cells by FRET imaging, Jie Yang, Zhihong Zhang, Bifeng Liu, Qingming Luo, 2006
Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis, Juqing Lin, Zhihong Zhang, Jie Yang, Shaoq

基因工程蛋白工程细胞生物学蛋白结构荧光蛋白细胞成像分子探针药物评价蛋白互作神经生物学

杭海英 - 中国科学院大学

杭海英 - 中国科学院大学

刘然 - 中国科学院大学

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